MYCOSTATIN SUMMARY
MYCOSTATIN® CREAM
Nystatin Cream USP
MYCOSTATIN® TOPICAL POWDER
Nystatin Topical Powder USP
Nystatin is a polyene antifungal antibiotic obtained from Streptomyces nursei.
Nystatin topical preparations are indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species.
These preparations are not indicated for systemic, oral, intravaginal or ophthalmic use.
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NEWS HIGHLIGHTS
Published Studies Related to Mycostatin (Nystatin Topical)
Comparison of therapeutic effect of aqueous extract of garlic and nystatin
mouthwash in denture stomatitis. [2012]
CONCLUSION: Considering the efficacy of garlic and lack of side effects for this
Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. [2011.05]
BACKGROUND: Invasive fungal infections are a major cause of morbidity and mortality in preterm infants. The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates... CONCLUSIONS: Prophylactic nystatin and fluconazole reduce the incidence of colonisation and invasive fungal infection in VLBW neonates. The authors believe that nystatin is an alternative to fluconazole, because nystatin is safe, inexpensive, well tolerated and effective.
Oral sustained release nystatin tablets for the treatment of oral candidiasis: formulation development and validation of UV spectrophotometric analytical methodology for content determination. [2010.05]
OBJECTIVE: In this study, oral sustained release mucoadhesive nystatin tablets were developed to increase nystatin contact time with the oral cavity and mask its unpleasant taste... CONCLUSION: The oral nystatin tablets developed showed to present faster therapeutic response than the oral aqueous solution through the preliminary clinical assays. The UV absorption spectrophotometry method showed to be an attractive test for the usual routine in the pharmaceutical industry.
Comparison of fluconazole and nystatin oral suspensions for prophylaxis of systemic fungal infection in very low birthweight infants. [2010.01]
We compared the efficacy and safety of fluconazole and nystatin oral suspensions for the prevention of systemic fungal infection (SFI) in very low birthweight infants. A prospective, randomized clinical trial was conducted over a 15-month period, from May 1997 through September 1998, in 80 preterm infants with birthweights <1500 g...
Effects of nystatin, fluconazole and propolis on poly(methyl methacrylate) resin surface. [2008]
The prevalence of candidosis in denture wearers is as well established as its treatment with antifungal agents (AAs). However, little research has been done regarding the effects of AAs on denture base surfaces... In conclusion, PRO was able to induce changes in PMMA surface properties, such as roughness, which could be related to microbial adhesion.
Clinical Trials Related to Mycostatin (Nystatin Topical)
Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis [Completed]
The purpose of this study was to see which one of two medicines (topical gentian violet [GV]
or nystatin oral suspension) was better than the other in treating Oral Candidiasis (OC).
This was measured by whether the study participant still had OC or sores in his/her mouth
after 14 days of treatment. Also, safety and tolerability of GV and nystatin in the
treatment of OC were assessed.
Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis [Completed]
The aim of the present study was to compare the effect of aqueous extract of garlic with
nystatin mouthwash in denture stomatitis.
Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections [Not yet recruiting]
A Study of Nystatin in HIV-Infected Patients [Completed]
To evaluate the clinical toxicity, safety, and potential anti-HIV activity of intravenous
nystatin in patients with HIV infection who have completed protocol FDA 103C. To evaluate
the safety and potential antiviral activity of intravenous nystatin and oral didanosine
(ddI) administered in an alternating regimen in this patient population.
A Phase I/II Clinical Study of Nystatin I.V. (Intravenous) in Patients With HIV Infection. [Completed]
To evaluate the clinical toxicity, safety, and maximum tolerated dose (MTD) of intravenous
nystatin in patients with HIV infection. To evaluate the potential anti-HIV activity and
clinical pharmacology of intravenous nystatin.
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