ADVERSE REACTIONS
Postoperative
The following adverse events have been associated with the use of NARCAN in postoperative patients: hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events. Excessive doses of NARCAN in postoperative patients may result in significant reversal of analgesia and may cause agitation (see PRECAUTIONS and DOSAGE AND ADMINISTRATION; Usage in Adults-Postoperative Opioid Depression).
Opioid Depression
Abrupt reversal of opioid depression may result in nausea, vomiting, sweating, tachycardia, increased blood pressure, tremulousness, seizures, ventricular tachycardia and fibrillation, pulmonary edema, and cardiac arrest which may result in death (see PRECAUTIONS).
Opioid Dependence
Abrupt reversal of opioid effects in persons who are physically dependent on opioids may precipitate an acute withdrawal syndrome which may include, but is not limited to, the following signs and symptoms: body aches, fever, sweating, runny nose, sneezing, piloerection, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, abdominal cramps, increased blood pressure, tachycardia. In the neonate, opioid withdrawal may also include: convulsions; excessive crying; hyperactive reflexes (see WARNINGS).
Adverse events associated with the postoperative use of NARCAN are listed by organ system and in decreasing order of frequency as follows:
Cardiac Disorders pulmonary edema, cardiac arrest or failure, tachycardia, ventricular fibrillation, and ventricular tachycardia. Death, coma, and encephalopathy have been reported as sequelae of these events.
Gastrointestinal Disorders vomiting, nausea
Nervous System Disorders convulsions, paraesthesia, grand mal convulsion
Psychiatric Disorders agitation, hallucination, tremulousness
Respiratory, Thoracic and Mediastinal Disorders dyspnea, respiratory depression, hypoxia
Skin and Subcutaneous Tissue Disorders nonspecific injection site reactions, sweating
Vascular Disorders hypertension, hypotension, hot flushes or flushing.
See also PRECAUTIONS and DOSAGE AND ADMINISTRATION; Usage in Adults; Postoperative Opioid Depression.
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REPORTS OF SUSPECTED NARCAN SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Narcan. The information is not vetted and should not be considered as verified clinical evidence.
Possible Narcan side effects / adverse reactions in 58 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-17
Patient: 58 year old female
Reactions: Agitation, Tachycardia, Toxicity TO Various Agents, Somnolence, Hyperhidrosis, Pupillary Disorder, Mental Impairment, Myoclonus, Multiple Drug Overdose, Hypertension
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Anticonvulsants
Indication: Product Used FOR Unknown Indication
Antipsychotics
Indication: Product Used FOR Unknown Indication
Benzodiazepine NOS
Indication: Product Used FOR Unknown Indication
Citalopram
Indication: Product Used FOR Unknown Indication
Fentanyl
Indication: Product Used FOR Unknown Indication
Hydrocodone Bitartrate
Indication: Product Used FOR Unknown Indication
Lovastatin
Indication: Product Used FOR Unknown Indication
Methocarbamol
Indication: Product Used FOR Unknown Indication
Methylphenidate
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Narcan
Indication: Product Used FOR Unknown Indication
Norco
Indication: Product Used FOR Unknown Indication
Thyroid Preparations
Indication: Product Used FOR Unknown Indication
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