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Narcan (Naloxone Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Postoperative

The following adverse events have been associated with the use of NARCAN in postoperative patients: hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events. Excessive doses of NARCAN in postoperative patients may result in significant reversal of analgesia and may cause agitation (see  PRECAUTIONS and DOSAGE AND ADMINISTRATION; Usage in Adults-Postoperative Opioid Depression).

Opioid Depression

Abrupt reversal of opioid depression may result in nausea, vomiting, sweating, tachycardia, increased blood pressure, tremulousness, seizures, ventricular tachycardia and fibrillation, pulmonary edema, and cardiac arrest which may result in death (see PRECAUTIONS).

Opioid Dependence

Abrupt reversal of opioid effects in persons who are physically dependent on opioids may precipitate an acute withdrawal syndrome which may include, but is not limited to, the following signs and symptoms: body aches, fever, sweating, runny nose, sneezing, piloerection, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, abdominal cramps, increased blood pressure, tachycardia. In the neonate, opioid withdrawal may also include: convulsions; excessive crying; hyperactive reflexes (see WARNINGS).

Adverse events associated with the postoperative use of NARCAN are listed by organ system and in decreasing order of frequency as follows:

Cardiac Disorders
pulmonary edema, cardiac arrest or failure, tachycardia, ventricular fibrillation, and ventricular tachycardia. Death, coma, and encephalopathy have been reported as sequelae of these events.

Gastrointestinal Disorders
vomiting, nausea

Nervous System Disorders
convulsions, paraesthesia, grand mal convulsion

Psychiatric Disorders
agitation, hallucination, tremulousness

Respiratory, Thoracic and Mediastinal Disorders
dyspnea, respiratory depression, hypoxia

Skin and Subcutaneous Tissue Disorders
nonspecific injection site reactions, sweating

Vascular Disorders
hypertension, hypotension, hot flushes or flushing.

See also  PRECAUTIONS and DOSAGE AND ADMINISTRATION; Usage in Adults; Postoperative Opioid Depression.



REPORTS OF SUSPECTED NARCAN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Narcan. The information is not vetted and should not be considered as verified clinical evidence.

Possible Narcan side effects / adverse reactions in 58 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-17

Patient: 58 year old female

Reactions: Agitation, Tachycardia, Toxicity TO Various Agents, Somnolence, Hyperhidrosis, Pupillary Disorder, Mental Impairment, Myoclonus, Multiple Drug Overdose, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Anticonvulsants
    Indication: Product Used FOR Unknown Indication

Antipsychotics
    Indication: Product Used FOR Unknown Indication

Benzodiazepine NOS
    Indication: Product Used FOR Unknown Indication

Citalopram
    Indication: Product Used FOR Unknown Indication

Fentanyl
    Indication: Product Used FOR Unknown Indication

Hydrocodone Bitartrate
    Indication: Product Used FOR Unknown Indication

Lovastatin
    Indication: Product Used FOR Unknown Indication

Methocarbamol
    Indication: Product Used FOR Unknown Indication

Methylphenidate
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Narcan
    Indication: Product Used FOR Unknown Indication

Norco
    Indication: Product Used FOR Unknown Indication

Thyroid Preparations
    Indication: Product Used FOR Unknown Indication



See index of all Narcan side effect reports >>

Drug label data at the top of this Page last updated: 2006-06-28

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