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Nardil (Phenelzine Sulfate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

NARDIL is a potent inhibitor of monoamine oxidase. Because this enzyme is widely distributed throughout the body, diverse pharmacologic effects can be expected to occur. When they occur, such effects tend to be mild or moderate in severity (see below), often subside as treatment continues, and can be minimized by adjusting dosage; rarely is it necessary to institute counteracting measures or to discontinue NARDIL.

Common side effects include:

Nervous System —Dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, weakness, tremors, twitching, myoclonic movements, hyperreflexia.

Gastrointestin al—Constipation, dry mouth, gastrointestinal disturbances, elevated serum transaminases (without accompanying signs and symptoms).

Metabolic —Weight gain.

Cardiovascular —Postural hypotension, edema.

Genitourinary —Sexual disturbances, eg, anorgasmia and ejaculatory disturbances and impotence.

Less common mild to moderate side effects (some of which have been reported in a single patient or by a single physician) include:

Nervous System —Jitteriness, palilalia, euphoria, nystagmus, paresthesias.

Genitourinary —Urinary retention.

Metabolic —Hypernatremia.

Dermatologic —Pruritus, skin rash, sweating.

Special Senses —Blurred vision, glaucoma.

Although reported less frequently, and sometimes only once, additional severe side effects include:

Nervous System —Ataxia, shock-like coma, toxic delirium, manic reaction, convulsions, acute anxiety reaction, precipitation of schizophrenia, transient respiratory and cardiovascular depression following ECT.

Gastrointestinal —To date, fatal progressive necrotizing hepatocellular damage has been reported in very few patients. Reversible jaundice.

Hematologic —Leukopenia.

Immunologic —Lupus-like syndrome

Metabolic —Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated CK levels, metabolic acidosis, hypoxia, coma and may resemble an overdose).

Respiratory —Edema of the glottis.

General —Fever associated with increased muscle tone.

Withdrawal may be associated with nausea, vomiting, and malaise.

An uncommon withdrawal syndrome following abrupt withdrawal of NARDIL has been infrequently reported. Signs and symptoms of this syndrome generally commence 24 to 72 hours after drug discontinuation and may range from vivid nightmares with agitation to frank psychosis and convulsions. This syndrome generally responds to reinstitution of low-dose NARDIL therapy followed by cautious downward titration and discontinuation.



REPORTS OF SUSPECTED NARDIL SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Nardil. The information is not vetted and should not be considered as verified clinical evidence.

Possible Nardil side effects / adverse reactions in 34 year old female

Reported by a lawyer from United States on 2011-11-14

Patient: 34 year old female weighing 77.1 kg (169.6 pounds)

Reactions: Impaired Work Ability, Encephalitis, Meningitis Viral, Superior Sagittal Sinus Thrombosis, Drug Abuse, Suicidal Ideation, Menstruation Irregular, Fatigue, RED Blood Cell Count Decreased, Plasminogen Activator Inhibitor Increased, Depression, Urinary Tract Infection, Hypotension, Condition Aggravated, Muscle Twitching, Mastoiditis, Antepartum Haemorrhage, Stress, Pleocytosis, Pregnancy, Transverse Sinus Thrombosis, Deep Vein Thrombosis

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Nardil
    Indication: Depression

Nuvaring
    Dosage: qm
    Indication: Contraception
    Start date: 2008-01-01
    End date: 2009-04-01

Nuvaring
    Dosage: qm
    Indication: Mood Altered
    Start date: 2008-01-01
    End date: 2009-04-01

Nuvaring
    Dosage: qm
    Indication: Contraception
    Start date: 2006-01-01

Nuvaring
    Dosage: qm
    Indication: Mood Altered
    Start date: 2006-01-01



Possible Nardil side effects / adverse reactions in 62 year old female

Reported by a physician from United States on 2011-11-15

Patient: 62 year old female weighing 72.6 kg (159.7 pounds)

Reactions: Thrombosis, Drug Ineffective, Joint Swelling, Oedema Peripheral

Suspect drug(s):
Pristiq
    Indication: Depression

Pristiq
    Indication: Anxiety

Pamelor
    Indication: Anxiety

Pamelor
    Indication: Depression

Abilify
    Indication: Depression

Abilify
    Indication: Anxiety

Remeron
    Indication: Anxiety

Remeron
    Indication: Depression

Wellbutrin
    Indication: Anxiety

Wellbutrin
    Indication: Depression

Prozac
    Indication: Anxiety

Prozac
    Indication: Depression

Cymbalta
    Indication: Anxiety

Cymbalta
    Indication: Depression

Paxil
    Indication: Depression

Paxil
    Indication: Anxiety

Zoloft
    Indication: Anxiety

Zoloft
    Indication: Depression

Nardil
    Dosage: 30 mg;bid;
    Indication: Anxiety
    Start date: 2010-12-28

Nardil
    Dosage: 30 mg;bid;
    Indication: Depression
    Start date: 2010-12-28



Possible Nardil side effects / adverse reactions in 62 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-17

Patient: 62 year old female weighing 72.7 kg (159.9 pounds)

Reactions: Thrombosis, Drug Ineffective, Oedema Peripheral

Suspect drug(s):
Abilify
    Indication: Depression

Zoloft
    Indication: Depression

Remeron
    Indication: Depression

Paxil
    Indication: Depression

Prozac
    Indication: Depression

Pamelor
    Indication: Depression

Nardil
    Dosage: 30mg twice per day
    Indication: Depression
    Start date: 2010-12-28

Cymbalta
    Indication: Depression

Wellbutrin
    Indication: Product Used FOR Unknown Indication

Pristiq
    Indication: Depression

Other drugs received by patient: Ambien



See index of all Nardil side effect reports >>

Drug label data at the top of this Page last updated: 2007-08-24

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