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Neobenz (Benzoyl Peroxide) - Description and Clinical Pharmacology

 
 



DESCRIPTION

NeoBenz Micro 3.5%, 5.5% and 8.5% creams are topical preparations containing benzoyl peroxide as the active ingredient incorporated into patented porous microspheres (Microsponge® System) composed of methyl methacrylate/glycol dimethacrylate crosspolymer. This polymeric system has been shown to provide gradual release of active ingredient into the skin.1 Other ingredients for all strengths include: water, glycerin, ethylhexyl palmitate, sorbitol, cetyl alcohol, glyceryl dilaurate, stearyl alcohol, magnesium aluminum silicate, silica, citric acid, xanthan gum, methylparaben, sodium citrate, propylparaben, polyacrylamide, C13-14 isoparaffin, laureth-7, sodium lauryl sulfate. The 8.5% cream also contains dimethicone.

Benzoyl peroxide is an oxidizing agent that possesses antibacterial properties and is classified as a keratolytic. Benzoyl peroxide (C14 H10 O4) is represented by the following structure:

CLINICAL PHARMACOLOGY

The exact method of action of benzoyl peroxide in acne vulgaris is not known. Benzoyl peroxide is an antibacterial agent with demonstrated activity against Propionibacterium acnes. This action, combined with the mild keratolytic effect of benzoyl peroxide is believed to be responsible for its usefulness in acne. Benzoyl peroxide is absorbed by the skin where it is metabolized to benzoic acid and excreted as benzoate in the urine.

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