ADVERSE REACTIONS
Reactions to procaine are characteristic of those associated with other ester-type local anesthetics. A major cause of adverse reactions to this group of drugs is excessive plasma levels which may be due to overdosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation.
A small number of reactions may result from hypersensitivity, idiosyncrasy, or diminished tolerance to normal dosage.
Systemic:
The most commonly encountered acute adverse experiences which demand immediate countermeasures are related to the central nervous system and the cardiovascular system. These adverse experiences are generally dose related and due to high plasma levels which may result from overdosage, rapid absorption from the injection site, diminished tolerance, or from unintentional intravascular injection of the local anesthetic solution. In addition to systemic dose-related toxicity, unintentional subarachnoid injection of drug during the intended performance of nerve blocks near the vertebral column (especially in the head and neck region), may result in underventilation or apnea (“Total or High Spinal”). Factors influencing plasma protein binding, such as acidosis, systemic diseases which alter protein production, or competition of other drugs for protein binding sites may diminish individual tolerance.
Plasma cholinesterase deficiency may also account for diminished tolerance to ester-type local anesthetics.
Central Nervous System Reactions:
These are characterized by excitation and/or depression. Restlessness, anxiety, dizziness, tinnitus, blurred vision, or tremors may occur, possibly proceeding to convulsions. However, excitement may be transient or absent, with depression being the first manifestation of an adverse reaction. This may quickly be followed by drowsiness merging into unconsciousness and respiratory arrest.
The incidence of convulsions associated with the use of local anesthetics varies with the procedure used and the total dose administered.
Cardiovascular Reactions:
High doses or inadvertent intravascular injection may lead to high plasma levels and related depression of the myocardium, decreased cardiac output, heartblock, hypotension (or sometimes hypertension), bradycardia, ventricular arrhythmias, and cardiac arrest. (See WARNINGS, PRECAUTIONS, and OVERDOSAGE sections.)
Allergic:
Allergic-type reactions are rare and may occur as a result of sensitivity to the local anesthetic or to other formulation ingredients, such as the antimicrobial preservative chlorobutanol contained in multiple-dose vials. These reactions are characterized by signs such as urticaria, pruritus, erythema, angioneurotic edema (including laryngeal edema), tachycardia, sneezing, nausea, vomiting, dizziness, syncope, excessive sweating, elevated temperature, and, possibly, anaphylactoid-like symptomatology (including severe hypotension). Cross sensitivity among members of the ester-type local anesthetic group has been reported. The usefulness of screening for sensitivity has not been definitely established.
Neurologic:
The incidences of adverse neurologic reactions associated with the use of local anesthetics may be related to the total dose of local anesthetic administered, and are also dependent upon the particular drug used, the route of administration, and the physical status of the patient. Many of these effects may be related to local anesthetic techniques, with or without a contribution from the drug.
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REPORTS OF SUSPECTED NOVOCAIN SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Novocain. The information is not vetted and should not be considered as verified clinical evidence.
Possible Novocain side effects / adverse reactions in 88 year old female
Reported by a consumer/non-health professional from United States on 2012-02-29
Patient: 88 year old female
Reactions: Hypersensitivity
Adverse event resulted in: hospitalization
Suspect drug(s):
Morphine
Novocain
Prednisone
Sulfur (Sulfur)
Tegretol
Tetanus Antitoxin (Tetanus Antitoxin)
Other drugs received by patient: Antacids (NO Ingredients/substances)
Possible Novocain side effects / adverse reactions in 88 year old female
Reported by a consumer/non-health professional from United States on 2012-02-29
Patient: 88 year old female
Reactions: Drug Hypersensitivity
Adverse event resulted in: hospitalization
Suspect drug(s):
Morphine
Novocain
Prednisone
Sulfur (Sulfur)
Tegretol
Tetanus (Tetanus Antitoxin)
Other drugs received by patient: Antacids (NO Ingredients/substances)
Possible Novocain side effects / adverse reactions in 88 year old female
Reported by a consumer/non-health professional from United States on 2012-02-29
Patient: 88 year old female
Reactions: Hypersensitivity
Adverse event resulted in: hospitalization
Suspect drug(s):
Morphine
Novocain
Prednisone
Sulfur (Sulfur)
Tegretol
Tetanus Antitoxin (Tetanus Antitoxin)
Other drugs received by patient: Antacids (NO Ingredients/substances)
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