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Novocaine Intraspinal (Procaine Hydrochloride Intraspinal) - Description and Clinical Pharmacology

 
 



NOVOCAIN®
PROCAINE HYDROCHLORIDE INJECTION, USP

10% Solution for Spinal Anesthesia

Rx only

DESCRIPTION

NOVOCAIN, procaine hydrochloride, is benzoic acid, 4-amino-, 2-(diethylamino) ethyl ester, monohydrochloride, the ester of diethylaminoethanol and aminobenzoic acid, with the following structural formula:

It is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol. Each mL contains 100 mg procaine hydrochloride and 4 mg acetone sodium bisulfite as antioxidant. DO NOT USE SOLUTIONS IF CRYSTALS, CLOUDINESS, OR DISCOLORATION IS OBSERVED. EXAMINE SOLUTIONS CAREFULLY BEFORE USE. REAUTOCLAVING INCREASES LIKELIHOOD OF CRYSTAL FORMATION.

CLINICAL PHARMACOLOGY

NOVOCAIN stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia. NOVOCAIN lacks surface anesthetic activity. The onset of action is rapid (2 to 5 minutes) and the duration of action is relatively short (average 1 to 1½ hours), depending upon the anesthetic technique, the type of block, the concentration, and the individual patient.

NOVOCAIN is readily absorbed following parenteral administration and is rapidly hydrolyzed by plasma cholinesterase to aminobenzoic acid and diethylaminoethanol.

A vasoconstrictor may be added to the solution of NOVOCAIN to promote local hemostasis, delay systemic absorption, and increase duration of anesthesia.

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