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Pentam (Pentamidine Isethionate) - Drug Interactions, Contraindications, Overdosage, etc



PENTAM drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.


A 17 month old infant inadvertently received 1600 mg of intravenous pentamidine isethionate which was followed by renal and hepatic function impairment, hypotension and cardiopulmonary arrest.  Treatment included cardiopulmonary resuscitation, epinephrine, atropine and intubation.  In addition, a four hour course of charcoal hemoperfusion was accompanied by reduction of pentamidine serum concentration and stabilization of the patient’s condition.  The patient recovered from these adverse events, but later died due to an unknown cause.1


Contraindicated in patients with a history of hypersensitivity to pentamidine isethionate.


  1. Watts RG; Conte JE, Jr.; Zurlinden E; Waldo FB: Effect of charcoal hemoperfusion on clearance of pentamidine isethionate after accidental overdose. J Toxicol Clin Toxicol 1997;35:89-92.



Revised: March 2008

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