Pentothal (Thiopental Sodium) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions include respiratory depression, myocardial depression, cardiac arrhythmias, prolonged somnolence and recovery, sneezing, coughing, bronchospasm, laryngospasm and shivering. Anaphylactic and anaphylactoid reactions to Pentothal (Thiopental Sodium for Injection) have been reported. Symptoms, e.g., urticaria, bronchospasm, vasodilation and edema should be managed by conventional means.

Rarely, immune hemolytic anemia with renal failure and radial nerve palsy have been reported.

ADVERSE REACTIONS

Reactions which may occur because of the diluent, technique of preparation or mixing, or administration of reconstituted solutions of Pentothal include febrile response or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.

If an adverse reaction does occur, discontinue the injection, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of unused solution (or the used container or syringe) for examination if deemed necessary.

REPORTS OF SUSPECTED PENTOTHAL SIDE EFFECTS / ADVERSE REACTIONS

Possible Pentothal side effects / adverse reactions in 37 year old female

Reported by a pharmacist from Canada on 2011-10-06

Patient: 37 year old female

Reactions: Torsade DE Pointes, Anaphylactic Reaction, Ventricular Arrhythmia, Bronchospasm, Respiratory GAS Exchange Disorder, Cardiac Arrest

Adverse event resulted in: life threatening event

Suspect drug(s):
Rocuronium Bromide
    Dosage: 50mg, once, , intravenous

Pentothal
    Dosage: 250mcg, once, , intravenous

Metoclopramide
    Dosage: 20mg, once, , intravenous

Fentanyl Citrate
    Dosage: 250mg, once, , intravenous

Other drugs received by patient: Acetaminophen; Morphine Sulfate

Possible Pentothal side effects / adverse reactions in 17 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-01-09

Patient: 17 year old female

Reactions: Multi-Organ Failure, Agranulocytosis, Histiocytosis Haematophagic, Condition Aggravated, Pancytopenia, Septic Shock

Adverse event resulted in: death, life threatening event, hospitalization

Suspect drug(s):
Keppra
    Dosage: unk
    Indication: Status Epilepticus
    Start date: 2008-12-06

Sufenta Preservative Free
    Dosage: unk
    Indication: Sedation
    Start date: 2008-11-29
    End date: 2008-12-25

Urbanyl
    Dosage: unk
    Indication: Status Epilepticus
    Start date: 2008-12-15

Cyclophosphamide
    Dosage: 750.0 mg, 1x/cyc
    Indication: Sjogren's Syndrome
    Start date: 2008-12-25

Phenobarbital TAB
    Dosage: unk
    Indication: Status Epilepticus
    Start date: 2008-12-01

Pentothal
    Dosage: unk
    Indication: Sedation
    Start date: 2008-12-08

Vancomycin HCL
    Dosage: unk
    Indication: Pneumonia Staphylococcal
    Start date: 2008-12-01

Piperacillin and Tazobactam
    Dosage: unk
    Indication: Escherichia Bacteraemia
    Start date: 2008-12-25

Pantoprazole Sodium
    Dosage: unk
    Indication: Prophylaxis Against Gastrointestinal Ulcer
    Start date: 2008-12-01

Diprivan
    Dosage: unk
    Indication: Sedation
    Start date: 2008-12-18

Depakene
    Dosage: unk
    Indication: Status Epilepticus
    Start date: 2008-12-26

Amikacin
    Dosage: unk
    Indication: Escherichia Bacteraemia
    Start date: 2008-12-25

Fosphenytoin Sodium
    Dosage: unk
    Indication: Status Epilepticus
    Start date: 2008-12-09
    End date: 2008-12-01

Other drugs received by patient: Paracetamol; Neostigmine; Duphalac; Solu-Medrol; Norepinephrine; Neupogen

Possible Pentothal side effects / adverse reactions in 17 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-01-09

Patient: 17 year old female

Reactions: Multi-Organ Failure, Histiocytosis Haematophagic, Agranulocytosis, Pancytopenia, Septic Shock

Adverse event resulted in: death, life threatening event, hospitalization

Suspect drug(s):
Depakene
    Dosage: unk
    Indication: Epilepsy
    Start date: 2008-12-26

Piperacillin and Tazobactam
    Dosage: unk
    Indication: Escherichia Infection
    Start date: 2008-12-25

Diprivan
    Dosage: unk
    Indication: Sedation
    Start date: 2008-12-18

Keppra
    Dosage: unk
    Indication: Epilepsy
    Start date: 2008-12-06

Amikacin
    Dosage: unk
    Indication: Escherichia Infection
    Start date: 2008-12-25

Pentothal
    Dosage: unk
    Indication: Sedation
    Start date: 2008-12-08

Urbanyl
    Dosage: unk
    Indication: Epilepsy
    Start date: 2008-12-15

Sufenta Preservative Free
    Dosage: unk
    Indication: Sedation
    Start date: 2008-11-29
    End date: 2008-12-25

Pantoprazole Sodium
    Dosage: unk
    Indication: Prophylaxis Against Gastrointestinal Ulcer
    Start date: 2008-12-01

Vancomycin HCL
    Dosage: unk
    Indication: Pneumonia Staphylococcal
    Start date: 2008-12-01

Fosphenytoin Sodium
    Dosage: 750 mg, cyclic
    Indication: Epilepsy
    Start date: 2008-12-11
    End date: 2008-12-01

Phenobarbital TAB
    Dosage: unk
    Indication: Epilepsy
    Start date: 2008-12-01

Cyclophosphamide
    Dosage: 750 mg
    Indication: Sjogren's Syndrome
    Start date: 2008-12-11

Other drugs received by patient: Duphalac; Neostigmine Bromide; Aciclovir; Neupogen; Norepinephrine Bitartrate; Claforan; Solu-Medrol; Paracetamol