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Percocet (Oxycodone Hydrochloride / Acetaminophen) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Serious adverse reactions that may be associated with PERCOCET tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock (see OVERDOSAGE).

The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus.

Hypersensitivity reactions may include: Skin eruptions, urticarial, erythematous skin reactions. Hematologic reactions may include: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.

Other adverse reactions obtained from postmarketing experiences with PERCOCET tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:

Body as a Whole

Anaphylactoid reaction, allergic reaction, malaise, asthenia, fatigue, chest pain, fever, hypothermia, thirst, headache, increased sweating, accidental overdose, non-accidental overdose

Cardiovascular

Hypotension, hypertension, tachycardia, orthostatic hypotension, bradycardia, palpitations, dysrhythmias

Central and Peripheral Nervous System

Stupor, tremor, paraesthesia, hypoaesthesia, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion, dizziness

Fluid and Electrolyte

Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

Gastrointestinal

Dyspepsia, taste disturbances, abdominal pain, abdominal distention, sweating increased, diarrhea, dry mouth, flatulence, gastro-intestinal disorder, nausea, vomiting, pancreatitis, intestinal obstruction, ileus

Hepatic

Transient elevations of hepatic enzymes, increase in bilirubin, hepatitis, hepatic failure, jaundice, hepatotoxicity, hepatic disorder

Hearing and Vestibular

Hearing loss, tinnitus

Hematologic

Thrombocytopenia

Hypersensitivity

Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction

Metabolic and Nutritional

Hypoglycemia, hyperglycemia, acidosis, alkalosis

Musculoskeletal

Myalgia, rhabdomyolysis

Ocular

Miosis, visual disturbances, red eye

Psychiatric

Drug dependence, drug abuse, insomnia, confusion, anxiety, agitation, depressed level of consciousness, nervousness, hallucination, somnolence, depression, suicide

Respiratory System

Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema

Skin and Appendages

Erythema, urticaria, rash, flushing

Urogenital

Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention



REPORTS OF SUSPECTED PERCOCET SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Percocet. The information is not vetted and should not be considered as verified clinical evidence.

Possible Percocet side effects / adverse reactions in 23 year old male

Reported by a consumer/non-health professional from United States on 2011-10-13

Patient: 23 year old male

Reactions: GUN Shot Wound, Drug Abuse

Adverse event resulted in: death

Suspect drug(s):
Percocet
    Indication: Drug Abuse

Oxycontin
    Indication: Drug Abuse



Possible Percocet side effects / adverse reactions in 22 year old female

Reported by a physician from United States on 2011-10-20

Patient: 22 year old female weighing 57.8 kg (127.2 pounds)

Reactions: Multiple Drug Overdose, Intentional Self-Injury, Loss of Consciousness

Adverse event resulted in: hospitalization

Suspect drug(s):
Percocet
    Indication: Product Used FOR Unknown Indication

Alcohol
    Indication: Product Used FOR Unknown Indication

Roxicet
    Indication: Product Used FOR Unknown Indication

Codeine Sulfate
    Indication: Product Used FOR Unknown Indication

Cyclobenzaprine Hydrochloride
    Indication: Self Injurious Behaviour

Carisoprodol
    Indication: Product Used FOR Unknown Indication

Vicodin
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Contraceptives



Possible Percocet side effects / adverse reactions in 53 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-21

Patient: 53 year old male weighing 85.0 kg (187.0 pounds)

Reactions: Pain, Oesophageal Obstruction, Skin Ulcer, Hypocalcaemia, Abdominal Distension, Decreased Appetite, Malabsorption, Vomiting, Stomatitis, Hyperglycaemia, Hypotension, Device Intolerance, Abdominal Infection, Sepsis, Dehydration, Hypoalbuminaemia

Adverse event resulted in: hospitalization

Suspect drug(s):
Zofran

Percocet

Cisplatin
    Indication: Head and Neck Cancer
    Start date: 2008-08-18
    End date: 2008-08-18



See index of all Percocet side effect reports >>

Drug label data at the top of this Page last updated: 2013-02-13

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