ADVERSE REACTIONS
Serious adverse reactions that may be associated with PERCOCET tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock (see OVERDOSAGE).
The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus.
Hypersensitivity reactions may include: Skin eruptions, urticarial, erythematous skin reactions. Hematologic reactions may include: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.
Other adverse reactions obtained from postmarketing experiences with PERCOCET tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:
Body as a Whole
Anaphylactoid reaction, allergic reaction, malaise, asthenia, fatigue, chest pain, fever, hypothermia, thirst, headache, increased sweating, accidental overdose, non-accidental overdose
Cardiovascular
Hypotension, hypertension, tachycardia, orthostatic hypotension, bradycardia, palpitations, dysrhythmias
Central and Peripheral Nervous System
Stupor, tremor, paraesthesia, hypoaesthesia, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion, dizziness
Fluid and Electrolyte
Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis
Gastrointestinal
Dyspepsia, taste disturbances, abdominal pain, abdominal distention, sweating increased, diarrhea, dry mouth, flatulence, gastro-intestinal disorder, nausea, vomiting, pancreatitis, intestinal obstruction, ileus
Hepatic
Transient elevations of hepatic enzymes, increase in bilirubin, hepatitis, hepatic failure, jaundice, hepatotoxicity, hepatic disorder
Hearing and Vestibular
Hearing loss, tinnitus
Hematologic
Thrombocytopenia
Hypersensitivity
Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction
Metabolic and Nutritional
Hypoglycemia, hyperglycemia, acidosis, alkalosis
Musculoskeletal
Myalgia, rhabdomyolysis
Ocular
Miosis, visual disturbances, red eye
Psychiatric
Drug dependence, drug abuse, insomnia, confusion, anxiety, agitation, depressed level of consciousness, nervousness, hallucination, somnolence, depression, suicide
Respiratory System
Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema
Skin and Appendages
Erythema, urticaria, rash, flushing
Urogenital
Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention
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REPORTS OF SUSPECTED PERCOCET SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Percocet. The information is not vetted and should not be considered as verified clinical evidence.
Possible Percocet side effects / adverse reactions in 23 year old male
Reported by a consumer/non-health professional from United States on 2011-10-13
Patient: 23 year old male
Reactions: GUN Shot Wound, Drug Abuse
Adverse event resulted in: death
Suspect drug(s):
Percocet
Indication: Drug Abuse
Oxycontin
Indication: Drug Abuse
Possible Percocet side effects / adverse reactions in 22 year old female
Reported by a physician from United States on 2011-10-20
Patient: 22 year old female weighing 57.8 kg (127.2 pounds)
Reactions: Multiple Drug Overdose, Intentional Self-Injury, Loss of Consciousness
Adverse event resulted in: hospitalization
Suspect drug(s):
Percocet
Indication: Product Used FOR Unknown Indication
Alcohol
Indication: Product Used FOR Unknown Indication
Roxicet
Indication: Product Used FOR Unknown Indication
Codeine Sulfate
Indication: Product Used FOR Unknown Indication
Cyclobenzaprine Hydrochloride
Indication: Self Injurious Behaviour
Carisoprodol
Indication: Product Used FOR Unknown Indication
Vicodin
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Contraceptives
Possible Percocet side effects / adverse reactions in 53 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-21
Patient: 53 year old male weighing 85.0 kg (187.0 pounds)
Reactions: Pain, Oesophageal Obstruction, Skin Ulcer, Hypocalcaemia, Abdominal Distension, Decreased Appetite, Malabsorption, Vomiting, Stomatitis, Hyperglycaemia, Hypotension, Device Intolerance, Abdominal Infection, Sepsis, Dehydration, Hypoalbuminaemia
Adverse event resulted in: hospitalization
Suspect drug(s):
Zofran
Percocet
Cisplatin
Indication: Head and Neck Cancer
Start date: 2008-08-18
End date: 2008-08-18
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