DRUG INTERACTIONS
Carcinogenesis, Mutagenesis, Impairment of Fertility
No information on long-term studies are available on the carcinogenesis, mutagenesis, or the impairment of fertility with the use of penicillins.
Pregnancy Category B
Teratogenic Effects
Reproduction studies performed in the mouse, rat, and rabbit have revealed no evidence of impaired fertility or harm to the fetus due to penicillin G. Human experience with the penicillins during pregnancy has not shown any positive evidence of adverse effects on the fetus. There are, however, no adequate and well controlled studies in pregnant women showing conclusively that harmful effects of these drugs on the fetus can be excluded. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
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OVERDOSAGE
Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required.
Penicillin G potassium is hemodialyzable.
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