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Plasbumin-25 (Albumin) - Drug Interactions, Contraindications, Overdosage, etc



Plasbumin-25 is compatible with whole blood, packed red cells, as well as the standard carbohydrate and electrolyte solutions intended for intravenous use. It should, however, not be mixed with protein hydrolysates, amino acid solutions nor those containing alcohol.


Certain patients, e.g., those with a history of congestive cardiac failure, renal insufficiency or stabilized chronic anemia, are at special risk of developing circulatory overload. A history of an allergic reaction to albumin is a specific contraindication to usage.


  1. Heyl JT, Gibson JG II, Janeway CA: Studies on the plasma proteins. V. The effect of concentrated solutions of human and bovine serum albumin on blood volume after acute blood loss in man. J Clin Invest 22:763-73, 1943.
  2. Tullis JL: Albumin. 1. Background and use. 2. Guidelines for clinical use. JAMA 237:355-60; 460-3, 1977.
  3. Comley A, Wood B: Albumin administration in exchange transfusion for hyperbilirubinaemia. Arch Dis Child 43:151-4, 1968.
  4. Janeway CA, Gibson ST, Woodruff LM, et al: Chemical, clinical, and immunological studies on the products of human plasma fractionation. VII. Concentrated human serum albumin. J Clin Invest 23:465-90, 1944.
  5. Skillman JJ, Tanenbaum BJ: Unrecognized losses of albumin, plasma, and red cells during abdominal vascular operations. Curr Top Surg Res 2:523-33, 1970.
  6. Zubiate P, Kay JH, Mendez AM, et al: Coronary artery surgery: a new technique with use of little blood, if any. J Thorac Cardiovasc Surg 68(2):263-7, 1974.
  7. Clowes GHA Jr, Vucinic M, Weidner MG: Circulatory and metabolic alterations associated with survival or death in peritonitis: clinical analysis of 25 cases. Ann Surg 163:866-85, 1966.
  8. Heyl JT, Janeway CA: The use of human albumin in military medicine. I. The theoretical and experimental basis for its use. US Navy Med Bull 40:785-91, 1942.
  9. Woodruff LM, Gibson ST: The clinical evaluation of human albumin. US Navy Med Bull 40:791-6, 1942.
  10. Janeway CA, Berenberg W, Hutchins G: Indications and uses of blood, blood derivatives and blood substitutes. Med Clin North Am 29:1069-94, 1945.

Bayer Corporation

Pharmaceutical Division

Elkhart, IN 46515 USA

U.S. License No. 8


Printed in USA                                        (Rev. February 2002)

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