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Proquin XR (Ciprofloxacin Hydrochloride) - Summary


Fluoroquinolones, including Proquin XR, are associated with an increased risk of tendinitis and tendon rupture in all ages. The risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart and lung transplant recipients (See  WARNINGS ).



Proquin® XR
(ciprofloxacin hydrochloride)
Extended-Release Tablets, 500 mg

ProQuin XR (ciprofloxacin hydrochloride) extended-release tablets contain ciprofloxacin hydrochloride, a synthetic broad-spectrum fluoroquinolone antimicrobial agent for oral administration. Ciprofloxacin hydrochloride is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride.

ProQuin XR is indicated only for the treatment of uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of the designated microorganisms listed below. ProQuin XR is not interchangeable with other ciprofloxacin extended-release or immediate release oral formulations. See DOSAGE AND ADMINISTRATION  for specific recommendations.

Uncomplicated urinary tract infections (acute cystitis) caused by Escherichia coli and Klebsiella pneumoniae.


To reduce the development of drug-resistant bacteria and maintain the effectiveness of ProQuin XR and other antibacterial drugs, ProQuin XR should only be used to treat uncomplicated urinary tract infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and sensitivity information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

See all Proquin XR indications & dosage >>


Published Studies Related to Proquin XR (Ciprofloxacin)

Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: a randomised, double-blind, placebo controlled trial (ADAFI). [2014]
disease (CD)... CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more

Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study. [2013]
This phase II, randomised, double-blind, multicentre study (NCT00930982) investigated the safety and efficacy of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic fibrosis bronchiectasis. Adults who were culture positive for pre-defined potential respiratory pathogens (including Pseudomonas aeruginosa and Haemophilus influenzae) were randomised to ciprofloxacin DPI 32.5 mg or placebo administered twice daily for 28 days (with 56 days of follow-up).

Evaluation of the efficacy and safety of intravenous ciprofloxacin versus meropenem in the treatment of postoperative infection. [2011.10.19]
Therapeutic options for postoperative infection in gastrointestinal surgery are limited. To identify new treatment alternatives, the Japan Society for Surgical Infection conducted a multicenter prospective, randomized, controlled clinical trial comparing the efficacy of intravenous ciprofloxacin (CIP IV) and intravenous meropenem (MEM IV).

A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. [2011.08]
CONCLUSIONS: We conclude that in Vietnam, where nalidixic acid resistant Shigellae are highly prevalent, ciprofloxacin and gatifloxacin are similarly effective for the treatment of acute shigellosis.

Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers. [2011.04]
OBJECTIVE: To investigate the pharmacokinetic interaction between ciprofloxacin and itraconazole in healthy male volunteers... CONCLUSION: Ciprofloxacin decreases the metabolism of itraconazole, most likely through inhibition of CYP3A4. The dosage of itraconazole should be reduced and its therapeutic outcome should be monitored closely when these two agents are concomitantly administered. Copyright (c) 2011 John Wiley & Sons, Ltd.

more studies >>

Clinical Trials Related to Proquin XR (Ciprofloxacin)

Study to Evaluate the Safety and Efficacy of Ciprofloxacin (Inhaled) in Patients With Cystic Fibrosis [Completed]
To evaluate the change in forced expiratory volume (FEV1) from baseline to Day 28-30 between Cipro Inhale-treated and placebo-treated subjects after a 4-week treatment period.

Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis [Completed]
The purpose of this study is to assess the Safety and Efficacy of Foam Otic Cipro (0. 3% Ciprofloxacin Otic Foam), used once-daily for 7 days for the treatment of Acute Diffuse Otitis Externa, compared to commercial ear drops used twice daily for 7 days.

Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa [Completed]
The purpose of this study is to assess the Safety and Efficacy of Foam Otic Cipro, a novel medication developed to treat Acute Diffuse Otitis Externa of bacterial origin. The working hypothesis is that Foam Otic Cipro is as effective as registered ear drops.

Impact of Formulation on Ciprofloxacin Oral Absorption [Completed]
The purpose of this research is to see if certain tablet formulation factors affect oral drug absorption. Medications taken by mouth, such as tablets, need to be absorbed into the body in order to do any good. Tablets contain a drug, but also contain non-drug ingredients that are called excipients or fillers. Excipients in the tablet, and the way in which the tablet is manufactured, both can impact how much drug is absorbed into the body. That is, tablet formulation factors can cause a tablet to be effective or not effective. Tablets in this research contain the drug ciprofloxacin hydrochloride. Ciprofloxacin is an antibiotic to treat infections, such as lung infections. This drug is being used since it has low water solubility and is probably sensitive to tablet formulation factors.

Drug - Drug Interaction Study of Quinine Sulfate and Ciprofloxacin [Completed]
Ciprofloxacin is moderate inhibitor of cytochrome P450 1A2 (CYP1A2), one of the enzymes responsible for the metabolism of quinine. This study will evaluate the effect of ciprofloxacin-related inhibition of CYP1A2 on the pharmacokinetics of quinine sulfate.

more trials >>


Based on a total of 7 ratings/reviews, Proquin XR has an overall score of 5. The effectiveness score is 7.14 and the side effect score is 5.71. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Proquin XR review by 52 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   kidney infection
Dosage & duration:   500mg 2 times daily (12 hrs apart) taken 1st day: 500 mg. 2 times/day for the period of Days 2-5: 250 mg every 8 hrs.
Other conditions:   Back pain: kidney area, frequent urination
Other drugs taken:   none
Reported Results
Benefits:   After the third day, I could tell the pain was subsiding.
Side effects:   Diarrhea and stomach pain
Comments:   The first dayI started taking the medication 500mg 12 hrs apart. Then my stomach was hurting and I had diarrhea. I decreased the dosage (on my own, which I would not advise others to do) because I have a history of pseudo-membranous colitis, and I need to be cautious of antibiotics. However, I needed the med for the kidney infection. On days 2-5 I took 250mg 3 times a day (eight hrs apart). This reduction in dosage relieved the stomach pain and the diarrhea. After the third day of antibiotics, I noticed a decrease in back pain so I knew the medication was working.


Proquin XR review by 61 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   pneumonia
Dosage & duration:   250mg taken 2 x day for the period of 7 days
Other conditions:   bronchiectasis
Other drugs taken:   none
Reported Results
Benefits:   My cough was reduced, from 24 hours a day, to a few episodes per day
Side effects:   First, what I termed "Cipro brain", which is not thiking clearly and making mistakes (like jet-lag). Then, I started getting ulcers on my tongue. They spread to my gums and inside lips and my tongue was swollen, making it difficult to talk. I was afraid that if I got stopped, driving, the cop would think I was drunk, because I was slurring my words. Now, several days after stopping the drug, I still have extreme fatigue. I'm hoping to return to normal! When I had pneumonia, I actually felt fine, but the cough had to to be treated. I doubt if I would ever take Ciprofloxacin again.
Comments:   I took the pill twice a day, morning and evening, after meals. I also kept up with my daily exercise regimen (walking and swimming).


Proquin XR review by 28 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   u/i
Dosage & duration:   500 2x a day for 5 days (dosage frequency: every 12 hours) for the period of 3.5 days
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   cleared my UI i didnt even know i had one..
Side effects:   feeling sick dizzy made vision in eye go funny. made tendons in whole body swell made muscels feel like they are burning. i cant excercise now because i have to let me tentons heal . i dont know how long it will take. brain fog extream fear and emotional .
Comments:   please dont ever take this medication im horrified by how it made me feel in such a short amout of time

See all Proquin XR reviews / ratings >>

Page last updated: 2014-11-30

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