NEWS HIGHLIGHTS
Published Studies Related to Provocholine (Methacholine)
Comparison of the dose response to levalbuterol with and without pretreatment
with S-albuterol after methacholine-induced bronchoconstriction. [2007]
methacholine challenge... CONCLUSION: A single high dose of S-albuterol did not alter the bronchodilator
A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on
methacholine hyperresponsiveness. [2006]
beclomethasone dipropionate (Beclate and Qvar)... CONCLUSIONS: Beclate and Qvar were equivalent for all primary and secondary
Formoterol induces tolerance to the bronchodilating effect of Salbutamol
following methacholine-provocation test in asthmatic children. [2006]
children... CONCLUSION: Formoterol decreases the bronchodilator response to salbutamol
The effect of reducing the fine-particle mass of salmeterol from metered-dose
inhalers on bronchodilatation and bronchoprotection against methacholine
challenge: a randomized, placebo-controlled, double-blind, crossover study. [2005]
hydrofluoroalkane (HFA)formulation... CONCLUSIONS: FPM from different MDI formulations may affect the bronchoprotective
Effects of HFA- and CFC-beclomethasone dipropionate on the bronchial response to
methacholine (MCh) in mild asthma. [2005]
Metered inhalers using chlorofluorocarbon (CFC) propellents have been gradually
replaced by new devices that use hydrofluoroalkanes (HFAs) as their propellents,
which are less harmful to the environment... The therapeutic performance
of BDP-HFA proved much higher and allowed the substantial reduction of the
therapeutic daily dose for the clinical asthma management, being the increased
and more peripheral deposition of BDP-HFA is presumed to play a crucial role.
Clinical Trials Related to Provocholine (Methacholine)
Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness [Completed]
The study will compare the airway responses to two bronchoconstricting agents, mannitol and
methacholine.
Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test [Recruiting]
The aim of the study is to compare standard spirometric evaluation of methacholine challenge
test with plethysmographic, interrupter technique and forced oscillation technique (FOT)
evaluation of the airways resistance.
The study group will consist of patients referred for methacholine challenge test. All
patient will undergo spirometric, plethysmographic, interrupter technique and FOT
examinations - before and after inhalation of aerosols. Patients will also undergo the
measurement of nitric oxide concentration in exhaled air and laboratory tests, including:
blood count, measurement of serum C-reactive protein, sodium, potassium, creatinine,
immunoglobulin E and N-Terminal pro-brain natriuretic peptide (NT-proBNP) concentration.
The investigators intend to assess, if plethysmographic, and/or interrupter, and/or FOT
measurement of bronchial reactivity can replace standard spirometric assessment.
Plethysmography, interrupter technique and FOT are much more easier to perform for patients.
Furthermore, those two techniques are less dependent on patient's motivation and cooperation
ability. Thus, usage of FOT, interrupter technique and/or plethysmography in bronchial
hyperreactivity testing could make methacholine challenge test more comfortable and
available for more patients. The investigators are also going to analyze the relationship
between exhaled nitric oxide and functional indices of bronchial hyperreactivity.
Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers [Recruiting]
The purpose of this study is to compare the diagnostic validity (sensitivity and
specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial
provocation tests with the Wright and Devilbiss646 nebulizers in asthmatic in Guangzhou.
A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population [Completed]
Asthmatic patients and non-asthmatic controls were recruited prospectively from four
referral hospitals in Korea. Participants were challenged with each of methacholine and
mannitol inhalation on different days. Their diagnostic utility was evaluated by calculating
their sensitivity and specificity for asthma diagnosis. Response-dose-ratio was also
compared.
Comparison of Two Methods of Bronchial Methacholine Provocation [Completed]
This study is meant to compare two routine diagnostic approaches in patients with bronchial
asthma. Patients are challenged with methacholine in order to measure their bronchial
response. We compare the evaluation of the effects of incremental concentrations versus
incremental dosages.
|
