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Provocholine (Methacholine Chloride) - Summary



Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes.

Provocholine®(methacholine chloride powder for inhalation) is indicated for the diagnosis of bronchial airway hyperreactivity in subjects who do not have clinically apparent asthma.

See all Provocholine indications & dosage >>


Published Studies Related to Provocholine (Methacholine)

Comparison of the dose response to levalbuterol with and without pretreatment with S-albuterol after methacholine-induced bronchoconstriction. [2007]
methacholine challenge... CONCLUSION: A single high dose of S-albuterol did not alter the bronchodilator

A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness. [2006]
beclomethasone dipropionate (Beclate and Qvar)... CONCLUSIONS: Beclate and Qvar were equivalent for all primary and secondary

Formoterol induces tolerance to the bronchodilating effect of Salbutamol following methacholine-provocation test in asthmatic children. [2006]
children... CONCLUSION: Formoterol decreases the bronchodilator response to salbutamol

The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: a randomized, placebo-controlled, double-blind, crossover study. [2005]
hydrofluoroalkane (HFA)formulation... CONCLUSIONS: FPM from different MDI formulations may affect the bronchoprotective

Effects of HFA- and CFC-beclomethasone dipropionate on the bronchial response to methacholine (MCh) in mild asthma. [2005]
Metered inhalers using chlorofluorocarbon (CFC) propellents have been gradually replaced by new devices that use hydrofluoroalkanes (HFAs) as their propellents, which are less harmful to the environment... The therapeutic performance of BDP-HFA proved much higher and allowed the substantial reduction of the therapeutic daily dose for the clinical asthma management, being the increased and more peripheral deposition of BDP-HFA is presumed to play a crucial role.

more studies >>

Clinical Trials Related to Provocholine (Methacholine)

Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness [Completed]
The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.

Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test [Recruiting]
The aim of the study is to compare standard spirometric evaluation of methacholine challenge test with plethysmographic, interrupter technique and forced oscillation technique (FOT) evaluation of the airways resistance. The study group will consist of patients referred for methacholine challenge test. All patient will undergo spirometric, plethysmographic, interrupter technique and FOT

examinations - before and after inhalation of aerosols. Patients will also undergo the

measurement of nitric oxide concentration in exhaled air and laboratory tests, including: blood count, measurement of serum C-reactive protein, sodium, potassium, creatinine, immunoglobulin E and N-Terminal pro-brain natriuretic peptide (NT-proBNP) concentration. The investigators intend to assess, if plethysmographic, and/or interrupter, and/or FOT measurement of bronchial reactivity can replace standard spirometric assessment. Plethysmography, interrupter technique and FOT are much more easier to perform for patients. Furthermore, those two techniques are less dependent on patient's motivation and cooperation ability. Thus, usage of FOT, interrupter technique and/or plethysmography in bronchial hyperreactivity testing could make methacholine challenge test more comfortable and available for more patients. The investigators are also going to analyze the relationship between exhaled nitric oxide and functional indices of bronchial hyperreactivity.

Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers [Recruiting]
The purpose of this study is to compare the diagnostic validity (sensitivity and specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial provocation tests with the Wright and Devilbiss646 nebulizers in asthmatic in Guangzhou.

A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population [Completed]
Asthmatic patients and non-asthmatic controls were recruited prospectively from four referral hospitals in Korea. Participants were challenged with each of methacholine and mannitol inhalation on different days. Their diagnostic utility was evaluated by calculating their sensitivity and specificity for asthma diagnosis. Response-dose-ratio was also compared.

Comparison of Two Methods of Bronchial Methacholine Provocation [Completed]
This study is meant to compare two routine diagnostic approaches in patients with bronchial asthma. Patients are challenged with methacholine in order to measure their bronchial response. We compare the evaluation of the effects of incremental concentrations versus incremental dosages.

more trials >>

Page last updated: 2015-08-10

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