Retin-A (Tretinoin Topical) - Summary

RETIN-A SUMMARY

RETIN-A Gel, Cream and Liquid, containing tretinoin are used for the topical treatment of acne vulgaris. RETIN-A Gel contains tretinoin (retinoic acid, vitamin A acid) in either of two strengths, 0.025% or 0.01% by weight, in a gel vehicle of butylated hydroxytoluene, hydroxypropyl cellulose and alcohol (denatured with tert- butyl alcohol and brucine sulfate) 90% w/w. RETIN-A (tretinoin) Cream contains tretinoin in either of three strengths, 0.1%, 0.05%, or 0.025% by weight, in a hydrophilic cream vehicle of stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. RETIN-A Liquid contains tretinoin 0.05% by weight, polyethylene glycol 400, butylated hydroxytoluene and alcohol (denatured with tert- butyl alcohol and brucine sulfate) 55%.

RETIN-A is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.

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NEWS HIGHLIGHTS

Published Studies Related to Retin-A (Tretinoin Topical)

Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. [2014]
CONCLUSION: The combination TR/AVG was well tolerated and significantly more

Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal antiwrinkle effect compared with conventional tretinoin: clinical and histologic studies of photoaged skin. [2012]
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. [2012]
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%

A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. [2012]
Vitamin A and its derivatives (commonly termed retinoids) are widely used in topical anti-aging products. Certain retinoids such as retinol and its esters are available without a prescription, while others such as tretinoin are available only via prescription... Subjects reported >93 percent overall satisfaction with both products at weeks 8 and 12.

Retinoic acid reduces chemotherapy-induced neuropathy in an animal model and patients with lung cancer. [2011.09.06]
OBJECTIVE: To evaluate the effect of all-trans retinoic acid (ATRA) as treatment for chemotherapy-induced peripheral neuropathy in an experimental animal model and in a randomized, double-blinded, controlled trial in patients with non-small-cell lung cancer (NSCLC)... CONCLUSIONS: ATRA reduced chemotherapy-induced experimental neuropathy, increased NGF levels, and induced RAR-beta expression in nerve. In patients, reduction of NGF in serum was associated with the severity of neuropathy; ATRA treatment reduced the electrophysiologic alterations. Classification of evidence: This study provides Class II evidence that ATRA improves nerve conduction in patients with chemotherapy-induced peripheral neuropathy.

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Clinical Trials Related to Retin-A (Tretinoin Topical)

90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) [Active, not recruiting]
This study is for patients with neuroblastoma or a neuroendocrine tumor who have not been able to have standard therapy or have failed the first-line therapy. The purpose of this study is to assess the safety and effectiveness of the combination of retinoic acid and Onalta (Y-90-DOTA-tyr3-Octreotide) in treating neuroblastoma and neuroendocrine tumors.

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Completed]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris [Active, not recruiting]
The purpose of this study is to evaluate whether Cerave lotion followed by Acanya Gel in the morning in combination with Cerave lotion followed by Atralin gel in the evening is safe and effective for the treatment of acne vulgaris.

Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Recruiting]
This phase I trial studies the side effects and best dose of tretinoin when given together with lithium carbonate in treating patients with relapsed or refractory acute myeloid leukemia. Lithium carbonate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Tretinoin may help [type of cancer] cells become more like normal cells, and to grow and spread more slowly. Giving lithium carbonate together with tretinoin may kill more cancer cells

Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro� and Placebo [Completed]
The objective will be to assess clinical bioequivalence of 0. 1% Retin-A Micro® Gel and Spear Pharmaceutical's generic 0. 1% Tretinoin Microsphere Gel with a placebo arm.

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PATIENT REVIEWS / RATINGS / COMMENTS

Retin-A review by 24 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		minor acne
Dosage & duration:		.01 (dosage frequency: every day) for the period of a year
Other conditions:		dry skin
Other drugs taken:		none
		Reported Results
Benefits:		My skin stopped breaking out as often and became much softer and smoother. The color really improved as well - much less blotchy and more "dewy."
Side effects:		Very dry skin. A lot of peeling.
Comments:		After washing my face with a gentle cleanser, I would wait 20 minutes and then put on the cream. I would then wait another 20 minutes and put some lotion on because the tretnoin was just too drying.

Retin-A review by 28 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		Acne
Dosage & duration:		0.01% (dosage frequency: once a day) for the period of 2 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Reduced acne. I had mild/moderate acne, and Retin-A did decrease the amount of ance I had. I liked Retin-A also because it reduces wrinkles. I am only 28, so I don't have many wrinkles, but used it as prevention.
Side effects:		My skin would become too dry. It seemed that even after months of usage, my ance would not completely disappear. If I used more Retin-A, my acne would get better for a week or two until my skin became too dry and then I would have worse acne
Comments:		I would apply Retin-A to my face once a day at night

Retin-A review by 16 year old female patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Acne
Dosage & duration:		Do not remember (dosage frequency: applied once a day) for the period of 3 months
Other conditions:		Acne only
Other drugs taken:		Antibiotics for acne
		Reported Results
Benefits:		Occasionally, acne would subside slightly.
Side effects:		Excessively dry skin and irritation
Comments:		I was to apply the Retin-A cream twice a day but the side effects outweighed any effects of treatment.