DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Spironolactone (Spironolactone) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The following adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity.

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.

Reproductive: Gynecomastia (see Precautions ), inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding, breast pain. Carcinoma of the breast has been reported in patients taking spironolactone but a cause and effect relationship has not been established.

Hematologic: Leukopenia (including agranulocytosis), thrombocytopenia.

Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.

Metabolism: Hyperkalemia, electrolyte disturbances (see Warnings   and Precautions ).

Musculoskeletal: Leg cramps.

Nervous system /psychiatric: Lethargy, mental confusion, ataxia, dizziness, headache, drowsiness.

Liver / biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration.

Renal: Renal dysfunction (including renal failure).

Skin: Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritus.



REPORTS OF SUSPECTED SPIRONOLACTONE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Spironolactone. The information is not vetted and should not be considered as verified clinical evidence.

Possible Spironolactone side effects / adverse reactions in 61 year old female

Reported by a consumer/non-health professional from United States on 2011-10-03

Patient: 61 year old female weighing 81.6 kg (179.6 pounds)

Reactions: Burning Sensation, Hair Texture Abnormal, Alopecia

Suspect drug(s):
Spironolactone



Possible Spironolactone side effects / adverse reactions in 87 year old female

Reported by a physician from Denmark on 2011-10-03

Patient: 87 year old female weighing 50.0 kg (110.0 pounds)

Reactions: Melaena

Adverse event resulted in: hospitalization

Suspect drug(s):
Metoprolol Succinate
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-08-24

Spironolactone
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-09-03

Digoxin
    Administration route: Oral
    Start date: 2011-08-24

Pradaxa
    Administration route: Oral
    Indication: Cerebrovascular Accident Prophylaxis
    Start date: 2011-08-25
    End date: 2011-09-05

Furosemide
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-08-24

Other drugs received by patient: Cordan



Possible Spironolactone side effects / adverse reactions in 52 year old female

Reported by a pharmacist from United States on 2011-10-04

Patient: 52 year old female

Reactions: Product Substitution Issue, Blood Pressure Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Spironolactone



See index of all Spironolactone side effect reports >>

Drug label data at the top of this Page last updated: 2014-04-24

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017