ADVERSE REACTIONS
The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA AND OTHER BLOOD DYSCRASIAS (SEE WARNINGS SECTION).
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.
Allergic Reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.
Gastrointestinal: Hepatitis (including cholestatic jaundice and hepatic necrosis), elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary: Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, crystalluria and nephrotoxicity in association with cyclosporine.
Metabolic and Nutritional: Hyperkalemia (see PRECAUTIONS: Use in the Treatment of and Prophylaxis for Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome (AIDS).
Neurologic: Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
Psychiatric: Hallucinations, depression, apathy, nervousness.
Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides) and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal: Arthralgia and myalgia. Isolated cases of rhabdomyolysis have been reported with sulfamethoxazole and trimethoprim, mainly in AIDS patients.
Respiratory: Cough, shortness of breath, pulmonary infiltrates (see WARNINGS).
Miscellaneous: Weakness, fatigue, insomnia.
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REPORTS OF SUSPECTED SULFAMETHOXAZOLE AND TRIMETHOPRIM SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Sulfamethoxazole and Trimethoprim. The information is not vetted and should not be considered as verified clinical evidence.
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 31 year old female
Reported by a physician from United States on 2011-10-03
Patient: 31 year old female
Reactions: Eosinophilic Myocarditis, Drug Rash With Eosinophilia and Systemic Symptoms
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Zonisamide
Indication: Migraine
Sulfamethoxazole and Trimethoprim
Indication: Respiratory Tract Infection
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 60 year old female
Reported by a physician from Japan on 2011-10-05
Patient: 60 year old female
Reactions: Bone Marrow Failure, Upper Respiratory Tract Inflammation, Blood Creatinine Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Bendamustine HCL
Indication: B-Cell Lymphoma
Start date: 2011-04-14
Fluconazole
Administration route: Oral
Indication: Infection Prophylaxis
Start date: 2011-04-12
End date: 2011-04-15
Allopurinol
Administration route: Oral
Start date: 2011-04-14
End date: 2011-04-15
Famotidine
Administration route: Oral
Start date: 2011-04-14
End date: 2011-04-15
Sulfamethoxazole and Trimethoprim
Start date: 2011-04-14
End date: 2011-04-15
Levofloxacin
Administration route: Oral
Indication: Infection Prophylaxis
Start date: 2011-04-12
End date: 2011-04-15
Other drugs received by patient: Rituximab
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 38 year old male
Reported by a pharmacist from United States on 2011-10-05
Patient: 38 year old male weighing 97.3 kg (214.1 pounds)
Reactions: Stomatitis, Pyrexia, LIP Ulceration, Odynophagia
Adverse event resulted in: hospitalization
Suspect drug(s):
Sulfamethoxazole and Trimethoprim
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