SUMATRIPTAN SUMMARY
Sumatriptan injection, USP contains sumatriptan (as the succinate), a selective 5-HT1B/1D receptor agonist.
Sumatriptan injection is indicated in adults for (1) the acute treatment of migraine, with or without aura, and (2) the acute treatment of cluster headache.
Limitations of Use:
- Use only if a clear diagnosis of migraine or cluster headache has been established.
- If a patient has no response to the first migraine attack treated with sumatriptan, reconsider the diagnosis of migraine before sumatriptan is administered to treat any subsequent attacks.
- Sumatriptan is not indicated for the prevention of migraine attacks.
|
|
NEWS HIGHLIGHTS
Published Studies Related to Sumatriptan
Reduced efficacy of sumatriptan in migraine with aura vs without aura. [2015] migraine with aura compared with migraine without aura... CONCLUSION: This post hoc analysis of pooled data from multiple randomized trials
Sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2014] SUMMARYÂ We will describe the pharmacokinetic profile, clinical efficacy and
safety data of the sumatriptan iontophoretic transdermal system (Zecuity®,
NuPathe Inc., PA, USA), recently approved for the acute treatment of migraine
with or without aura in adults, by the US FDA.This sumatriptan transdermal system may be a good choice for migraineurs with
severe nausea or vomiting, those with intolerable triptan-related adverse events
and/or those not responding optimally to oral medications.
Sumatriptan plus naproxen for acute migraine attacks in adults. [2013] CONCLUSIONS: Combination treatment was effective in the acute treatment
A sumatriptan iontophoretic transdermal system for the acute treatment of
migraine. [2012] treatment of migraine... CONCLUSIONS: The sumatriptan iontophoretic transdermal system is effective and
Sumatriptan (subcutaneous route of administration) for acute migraine attacks in
adults. [2012] CONCLUSIONS: Subcutaneous sumatriptan is effective as an abortive
Clinical Trials Related to Sumatriptan
A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period [Completed]
The purpose of this study is to test the effect on blood pressure of sumatriptan and
naproxen sodium combination tablets, tablets containing only sumatriptan, and tablets
containing only naproxen sodium when these drugs are taken to treat migraine headaches that
occur during a 6-month period.
Bioavailability Study to Compare OPTINOSE SUMATRIPTAN With IMITREX� in Healthy Subjects [Completed]
The purpose of this study is:
- To compare the single-dose pharmacokinetics (PK) of intranasal administration of 20 mg
OPTINOSE SUMATRIPTAN with 20 mg IMITREX® (sumatriptan) Nasal Spray, 100 mg IMITREX®
(sumatriptan) Oral Tablet, and 6 mg IMITREX® (sumatriptan) Subcutaneous Injection, in
healthy subjects.
- To estimate the relative bioavailability of single-dose intranasal administration of 20
mg OPTINOSE SUMATRIPTAN, 20 mg IMITREX® (sumatriptan) Nasal Spray, and 100 mg IMITREX®
(sumatriptan) Oral Tablet compared to a single-dose of 6 mg IMITREX® (sumatriptan)
Subcutaneous Injection, in healthy subjects.
The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy
volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor
(cilostazol). If the headache responds to sumatriptan, the model can be used to test new
drug candidates.
The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy
volunteers and in patients with migraine without aura with a long lasting Nitrogen Oxide
(NO) donor. If the headache responds to sumatriptan, the model can be used to test new drug
candidates.
Sumatriptan and Naratriptan Pregnancy Registry [Completed]
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However,
the peak prevalence of migraine is in women of childbearing age. This, coupled with the
sporadic nature of migraine attacks and high rates of unplanned pregnancies, makes
unintentional exposure to anti-migraine medications during pregnancy likely. Prior to an
anti-migraine medication being marketed there are few data available on drug safety in
pregnancy: data from animal models may not translate directly to humans and pregnant women
are routinely excluded from clinical trials. The Sumatriptan Pregnancy Registry was
established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during
pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data
collection on the sumatriptan-naproxen combination (Treximet) began in 2008.
Reports of Suspected Sumatriptan Side Effects
Drug Ineffective (18),
Product Quality Issue (13),
Maternal Drugs Affecting Foetus (6),
Chest Discomfort (6),
Apnoea (5),
Nausea (5),
Bradycardia (5),
Product Substitution Issue (4),
Hypersensitivity (4),
Foetal Exposure During Pregnancy (4), more >>
|
PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Sumatriptan has an overall score of 9.50. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Sumatriptan review by 43 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | maigrains |
Dosage & duration: | | 1 (dosage frequency: once a month) for the period of one week ago |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | ceasation of maigrain. The drug provides relive within half an hour of having been administered and prevents further symptomps |
Side effects: | | there are no aparent side effects from the use of this drug |
Comments: | | 1 pill to be taken with onset of attack. If the attack has already started and the treatment cannot be reached within the first 5 hours of the attack, a further dose of the drug may be required |
|
| Sumatriptan review by 49 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | migraine |
Dosage & duration: | | 50 mg taken once a week for the period of one to four doses |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | The drug rapidly gets rid of migraine. |
Side effects: | | The drug causes slight dizziness and tightness around my temples. Sometimes I also feel slightly nauseated after taking it, but perhaps I should blame the headache and not the medication. |
Comments: | | I take one dose at onset of headache. I repeat doses of the drug at one hour intervals if headache gets better but then worsens again. |
|
| Sumatriptan review by 49 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | migraine |
Dosage & duration: | | 50 mg taken once a week for the period of one to four doses |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | The drug rapidly gets rid of migraine. |
Side effects: | | The drug causes slight dizziness and tightness around my temples. Sometimes I also feel slightly nauseated after taking it, but perhaps I should blame the headache and not the medication. |
Comments: | | I take one dose at onset of headache. I repeat doses of the drug at one hour intervals if headache gets better but then worsens again. |
|
|
Page last updated: 2015-08-10
|