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Syntocinon (Oxytocin) - Summary




Syntocinon® (oxytocin) is a synthetic, (1-6) cyclic nonapeptide.

Important Notice

Syntocinon® (oxytocin) injection is indicated for the medical rather than the elective induction of labor. Available data and information are inadequate to define the benefits to risk considerations in the use of the drug product for elective induction. Elective induction of labor is defined as the initiation of labor for convenience in an individual with a term pregnancy who is free of medical indications.

Syntocinon® (oxytocin) is indicated for the initiation or improvement of uterine contractions, where this is desirable and considered suitable, in order to achieve early vaginal delivery for fetal or maternal reasons. It is indicated for (1) induction of labor in patients with a medical indication for the initiation of labor, such as Rh problems, maternal diabetes, pre-eclampsia at or near term, when delivery is in the best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated; (2) stimulation or reinforcement of labor, as in selected cases of uterine inertia; (3) as adjunctive therapy in the management of incomplete or inevitable abortion. In the first trimester, curettage is generally considered primary therapy. In the second trimester abortion, oxytocin infusion will often be successful in emptying the uterus. Other means of therapy, however, may be required in such cases.


Syntocinon® (oxytocin) injection is indicated to produce uterine contractions during the third stage of labor and to control postpartum bleeding or hemorrhage.

See all Syntocinon indications & dosage >>


Published Studies Related to Syntocinon (Oxytocin)

Intranasal oxytocin administration prior to exposure therapy for arachnophobia impedes treatment response. [2015]
exposure therapy in patients with specific phobia... CONCLUSIONS: These results suggest that OT administration effects on extinction

Safety and efficacy of misoprostol versus oxytocin for the prevention of postpartum hemorrhage. [2014]
Postpartum hemorrhage (PPH) is the commonest cause of maternal death worldwide. Studies suggest that the use of misoprostol may be beneficial in clinical settings where oxytocin is unavailable... Results from this study indicate that it may be considered as an alternative for oxytocin in low resource clinical settings.

Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction. [2014]
Both oxytocin (OT) and vasopressin (AVP) are known to modulate social behavior, and dysfunction in both systems has been postulated as a potential cause of certain psychiatric disorders that involve social behavioral deficits. In particular, there is growing interest in intranasal OT as a potential treatment for certain psychiatric disorders, and preliminary pre-clinical and clinical studies suggest efficacy in alleviating some of the associated symptoms...

Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome. [2014]
The neuropeptide oxytocin has recently been shown to enhance eye gaze and emotion recognition in healthy men. Here, we report a randomized double-blind, placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome (AS), a clinical condition characterized by impaired eye gaze and facial emotion recognition...

Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism. [2014]
Recent studies have suggested oxytocin's therapeutic effects on deficits in social communication and interaction in autism spectrum disorder through improvement of emotion recognition with direct emotional cues, such as facial expression and voice prosody... The present findings suggest that oxytocin enhances the ability to understand others' social emotions that have also required second-order false belief rather than first-order false beliefs under conditions without direct emotional cues in autism spectrum disorder at both the behaviour and neural levels.

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Clinical Trials Related to Syntocinon (Oxytocin)

The Effect of Oxytocin on the Gastric Emptying [Completed]
The investigators are going to examine whether oxytocin has a prokinetic effect on gastric emptying in patients suffering from gastro paresis. Oxytocin infusion will be compared with sodium chloride infusion.

Oxytocin Modulation of Startle Reactivity to Social Stimuli and Moral Decision Making [Completed]
The purpose of this study is to determine whether oxytocin affects the modulation of startle reactivity by aversive social stimuli and to investigate the oxytocin effect on moral judgements. Furthermore the investigators explore the effects of oxytocin receptor (OXTR) polymorphisms on behavioral responses to social stimuli.

Deciphering the Role of Oxytocin in Motivation: an fMRI Study [Active, not recruiting]
The proposed study will investigate the effects of intranasal oxytocin administration on neural activity associated with social and non-social motivation.

A Study of Oxytocin in Children and Adolescents With Autistic Disorder [Completed]
The investigators propose to conduct this pilot study to evaluate oxytocin as a supplemental treatment for improving social difficulties in individuals with autism.

Oxytocin Treatment of Schizophrenia [Active, not recruiting]
Purpose: Test whether intranasal administration of the neuropeptide, oxytocin, improves social cognition, social functioning and decreases paranoia and other psychotic symptoms in schizophrenia. Participants: 80 adults with schizophrenia for at least one year and with a high rating for paranoia. Procedures (methods): Oxytocin or placebo will be administered twice daily in an intranasal spray (6 insufflations/dose or 24 IU) for 6 weeks. Before, during and at the end of the trial, each subject will undergo psychiatric symptom ratings and tests of mental abilities used in social functioning and social competence and subjects and an informant will complete ratings of social functioning.

more trials >>

Reports of Suspected Syntocinon (Oxytocin) Side Effects

Postpartum Haemorrhage (9)Maternal Exposure During Pregnancy (4)Agitation (2)Akathisia (2)Rhabdomyolysis (2)Hyperpyrexia (2)Chills (2)Pyrexia (2)Pallor (2)Hallucination (2)more >>

Page last updated: 2015-08-10

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