WARNING: FETAL TOXICITY
-
When pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible.
-
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (see WARNINGS, Fetal Toxicity).
|
|
SUMMARY
Telmisartan and hydrochlorothiazide
tablets, USP are a combination of telmisartan, an orally active angiotensin II antagonist acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic.
Telmisartan and hydrochlorothiazide tablets, USPĀ are indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).
|
|
NEWS HIGHLIGHTS
Published Studies Related to Telmisartan and Hydrochlorothiazide (Telmisartan / Hydrochlorothiazide)
[A randomized, double-blind, double-dummy study comparing a fixed dose
combination of telmisartan 80 mg plus hydrochlorothiazide 12.5 mg to telmisartan
80 mg in Chinese hypertensive patients who failed to respond adequately to
telmisartan 80 mg]. [Article in Chinese] [2008] CONCLUSION: TH was more effective than T in patients not responded adequately to
Effects of the angiotensin II receptor blockers telmisartan versus valsartan in
combination with hydrochlorothiazide: a large, confirmatory trial. [2008] In 2004-2005, the antihypertensive effects of telmisartan 80 mg versus valsartan
160 mg combined with hydrochlorothiazide 25 mg were assessed in a large
placebo-controlled trial in patients with stages 1 and 2 hypertension and
demonstrated that both agents were highly effective in lowering blood pressure
(BP) compared with placebo and that telmisartan lowered BP significantly greater
than valsartan...
Design, statistical analysis and sample size calculation of dose response study
of telmisartan and hydrochlorothiazide. [2007] Many patients with hypertension take some antihypertensive drugs with
complementary mechanisms of action to lower their blood pressure and achieve the
therapeutic goals reducing the risk of cardiovascular events. Telmisartan,
angiotensin II receptor blocker, and hydrochlorothiazide, diuretic are two
antihypertensive drugs that have a well-recognized clinical efficacy...
Effects of the angiotensin II receptor blockers telmisartan vs valsartan in
combination with hydrochlorothiazide 25 mg once daily for the treatment of
hypertension. [2006] To attain recent goals of blood pressure (BP) control, multiple drug therapy
combinations are required, including higher doses of thiazide diuretics in
combination with other classes of antihypertensive drug therapy. Thus, the
authors evaluated the antihypertensive effects of telmisartan vs valsartan when
combined with hydrochlorothiazide (HCTZ) 25 mg in a large (N=1066),
placebo-controlled trial in patients with stage 1 or 2 hypertension.
Freehand three-dimensional echocardiographic evaluation of the effect of
telmisartan compared with hydrochlorothiazide on left ventricular mass in
hypertensive patients with mild-to-moderate hypertension: a multicentre study. [2004] Antihypertensive efficacy, effects on left ventricular mass index (LVMI) and
tolerability of telmisartan, an angiotensin II receptor blocker, were compared
with those of hydrochlorothiazide (HCTZ). Adult patients with mild-to-moderate
hypertension and an optimal acoustic window by two-dimensional echocardiography
were randomised at baseline to 12 months' double-blind, once-daily treatment with
telmisartan 80 mg or HCTZ 25 mg.
Clinical Trials Related to Telmisartan and Hydrochlorothiazide (Telmisartan / Hydrochlorothiazide)
CKD-828 Drug Interaction Study (Telmisartan) [Completed]
The purpose of this study is to evaluate the Pharmacokinetic drug interaction and safety of
Telmisartan between free combination of Telmisartan and S-amlodipine and Telmisartan
monotherapy.
Study to Investigate the Effect of Atorvastatin on the Pharmacokinetic Properties of Telmisartan/S-amlodipine [Completed]
Telmisartan, Amlodipine and Combination in Healthy Subjects [Completed]
To determine the pharmacokinetic profile of 80 mg telmisartan / 5 mg amlodipine (T80/A5)
dose combination after single dose in healthy Chinese subjects.
To determine whether a pharmacokinetic interaction exists between telmisartan and
amlodipine, following single doses of 80mg telmisartan (T80), and 5 mg amlodipine (A5)
tablet alone and in combination, in healthy Chinese subjects.
To evaluate the safety and tolerability of T80 and A5 alone and in combination in healthy
Chinese subjects.
Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease [Recruiting]
The aim of this current study was to assess the therapeutic effects of perindopril and
telmisartan for hypertensive patients with NAFLD and make comparison between the therapeutic
effects of these two kind of drugs.
This study is a randomized parallel control clinical trial which would be carried out in
Nanfang Hospital, Southern Medical University.
About one hundred and eighty patients would be randomly assigned to perindopril,telmisartan
and amlodipine three groups.
|
|
Page last updated: 2015-08-10
|