Trental (Pentoxifylline) - Summary

TRENTAL SUMMARY

TRENTAL® (pentoxifylline) tablets for oral administration contain 400 mg of the active drug in a controlled-release formulation.

TRENTAL is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs. TRENTAL can improve function and symptoms but is not intended to replace more definitive therapy, such as surgical bypass, or removal of arterial obstructions when treating peripheral vascular disease.

See all Trental indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Trental (Pentoxifylline)

Pentoxifylline decreases serum level of adhesion molecules in atherosclerosis patients. [2014]
with coronary artery disease (CAD)... CONCLUSION: Based on the results of our pilot study, administration of PTX in CAD

Pentoxifylline for intermittent claudication. [2012]
CONCLUSIONS: Given the generally poor quality of the published studies

Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. [2011.11]
CONCLUSION: PTX improved histological features of NASH compared to placebo. PTX was well tolerated in patients with NASH. Copyright (c) 2011 American Association for the Study of Liver Diseases.

Pentoxifylline decreases serum levels of tumor necrosis factor alpha, interleukin 6 and C-reactive protein in hemodialysis patients: results of a randomized double-blind, controlled clinical trial. [2011.10.03]
CONCLUSIONS: Pentoxifylline significantly decreased serum concentrations of TNF-alpha, IL-6 and CRP compared to placebo. Pentoxifylline could be a promising and useful strategy to reduce the systemic inflammation frequently observed in patients on HD.

Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. [2011.09]
PURPOSE: The detection of tumor necrosis factor-a (TNF-a) in conjunctiva affected by ocular cicatricial pemphigoid (OCP) may indicate that this cytokine plays an important role in its pathogenesis. The purpose of this randomized, controlled, comparative, blinded study was to evaluate the effectiveness of adding pentoxifylline as an anti-TNF-a drug to the well-documented therapy of steroids and cyclophosphamide in controlling OCP... CONCLUSIONS: The significantly increased level of serum TNF-a in OCP as compared to controls proves that TNF-a has an important role in the pathogenesis of this disease. The study illustrates that the addition of pentoxifylline to pulse steroid cyclophosphamide therapy is an effective, safe, and economical method in controlling OCP through directly reducing TNF-a levels, with long periods of remission as detected in our 18-month follow-up period.

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Clinical Trials Related to Trental (Pentoxifylline)

Renal Effect of Pentoxyphylline in High Risk Patients Undergoing Angiography [Withdrawn]
The investigators will study 2 separate groups:

- Cardiology patients undergoing invasive coronary angiography +/- PCI (Percutaneous

coronary intervention).

- Patients undergoing CT examination with contrast medium. All patients will receive

intravenous (I. V) hydration for 8-12h before and 36 to 48 h after angiography with 0. 45% saline 100ml/h. All patients will receive oral N-acetyl cysteine 1200 mg twice daily, a day before, on the day of the angiography and for another 48 hours. In addition, patients will be assigned to receive oral pentoxyphylline (P group) or placebo

(C - control group) tablets 3 times a day one day before, on the day of the procedure and

for another 48 hours. Baseline Serum Creatinine (S. Cr) levels in will be taken before angiography and two days after angiography. Radio-contrast nephropathy is defined, in this study, as increase in serum ≥ 25 % of baseline after injection of the radio-contrast agent. Pentoxyfylline is an orally active haemorheological agent for the treatment of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation. Pentoxyfylline acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation (mechanism unclear). Pentoxyfylline has also proven to have a significant anti inflammatory effect as well as anti oxidant effect, mechanisms considered to be important patho-physiological causes of contrast induced nephropathy.

Prevention of Capsular Contracture Using Trental and Vitamin E [Active, not recruiting]
The main purpose of this research study is to determine if the use of Trental and Vitamin E will decrease the incidence and severity of contractures (shrinking and or hardening of tissue surrounding the implant) associated with breast implant reconstruction following radiation treatment. Another goal is to find out the impact that Trental and Vitamin E have on implant loss or need for surgical intervention in the setting of chest wall radiation after reconstruction. In addition, the investigators want to evaluate the patient's sense of well being and quality of life.

Effect of Pentoxifylline on Proteinuria in Korean Type 2 Diabetic Patients [Recruiting]

Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH [Completed]

Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis [Recruiting]
The purpose of this study is to determine whether the use of Trental and Vitamin E can help reduce the incidence of radiation necrosis (a lesion that usually occurs at the original tumor site) after radiosurgery. These two drugs are commonly used to treat radiation necrosis when it occurs but the hope is that these drugs can be used to prevent radiation necrosis from ever occurring.

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Reports of Suspected Trental (Pentoxifylline) Side Effects

Hypotension (8),  Bradyphrenia (8),  Hyponatraemia (7),  Asthenia (7),  Pain (4),  Dizziness (4),  Inappropriate Antidiuretic Hormone Secretion (3),  Gingivitis (2),  Pruritus (2),  Headache (2), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Trental review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		HIV
Dosage & duration:		400 mg taken tid for the period of 1 month
Other conditions:		fibromyalgia
Other drugs taken:		norco and soma
		Reported Results
Benefits:		The Trental reduced my viral load, increased my sex drive from none to moderate and the side effects were just some stomach upset, which was fixed by reducing my dose to twice a day.
Side effects:		Mild nausea and mild dizziness that were dose related.
Comments:		I wanted to see if the Trental would reduce my viral load and it did.

Trental review by 21 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Behcet's Disease
Dosage & duration:		400mg taken three times daily for the period of 1 year
Other conditions:		osteoperosis
Other drugs taken:		protium, risedronate, movox, colchicine
		Reported Results
Benefits:		Reduced stickiness of the blood.If inflammation of blood vessels did occur, the blood was thinner and so could get through vessels with reduced occurence of ulceration. General overall improval of condition.
Side effects:		Minimal side effects, some nausea- very minimal.
Comments:		Inconvient to remember to take as they are required three or four times daily. Overall very pleased with results.