ADVERSE REACTIONS
Side effects observed in association with the use of triamterene and hydrochlorothiazide tablets, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:
Gastrointestinal: jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.
Central Nervous System: drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.
Cardiovascular: tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).
Renal: acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.
Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.
Ophthalmic: xanthopsia, transient blurred vision.
Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.
Other: muscle cramps and weakness, decreased sexual performance and sialadenitis.
Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.
Altered Laboratory Findings
Serum Electrolytes: hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see
WARNINGS
and
PRECAUTIONS).
Creatinine, Blood Urea Nitrogen: Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with triamterene and hydrochlorothiazide.
Glucose: hyperglycemia, glycosuria and diabetes mellitus (see
PRECAUTIONS).
Serum Uric Acid, PBI and Calcium: (see
PRECAUTIONS).
Other: Elevated liver enzymes have been reported in patients receiving triamterene and hydrochlorothiazide.
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REPORTS OF SUSPECTED TRIAMTERENE AND HYDROCHLOROTHIAZIDE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Triamterene and Hydrochlorothiazide. The information is not vetted and should not be considered as verified clinical evidence.
Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 69 year old female
Reported by a consumer/non-health professional from United States on 2011-10-11
Patient: 69 year old female weighing 66.7 kg (146.7 pounds)
Reactions: Headache, Amnesia, Arrhythmia, Paraesthesia, Generalised Oedema, Product Measured Potency Issue, Sinus Headache, Alopecia, Unevaluable Event, Hypersomnia
Suspect drug(s):
Warfarin Sodium
Dosage: 5 mg;qd;po
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2007-01-01
Propranolol
Synthroid
Digoxin
Triamterene and Hydrochlorothiazide
Dosage: 37.5 mg
Indication: Fluid Retention
Start date: 2006-01-01
Round-UP (NO Pref. Name)
Other drugs received by patient: Lanoxin; Vitamin D; Estrogen Cream; Atenolol; Methyfolate; Thyroid TAB; Vitamin B Complex CAP; Magnesium; Loratadine
Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 50 year old female
Reported by a consumer/non-health professional from United States on 2011-10-12
Patient: 50 year old female
Reactions: Pruritus Generalised, Arterial Occlusive Disease, Rash
Suspect drug(s):
Pradaxa
Dosage: 300 mg
Administration route: Oral
Indication: Atrial Flutter
Start date: 2011-08-02
Triamterene and Hydrochlorothiazide
Indication: Diuretic Therapy
End date: 2011-10-06
Other drugs received by patient: Vitamin TAB; Sotalol HCL
Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 69 year old female
Reported by a consumer/non-health professional from United States on 2011-10-24
Patient: 69 year old female weighing 66.7 kg (146.7 pounds)
Reactions: Headache, Paraesthesia, Arrhythmia, Generalised Oedema, Product Measured Potency Issue, Sinus Headache, Alopecia, Unevaluable Event, Memory Impairment, Hypersomnia
Suspect drug(s):
Round-UP (NO Pref. Name)
Synthroid
Warfarin Sodium
Dosage: 5 mg;qd;po
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2007-01-01
Propranolol
Digoxin
Triamterene and Hydrochlorothiazide
Dosage: 37.5 mg;
Indication: Fluid Retention
Start date: 2006-01-01
Other drugs received by patient: Lanoxin; Vitamin D; Loratadine; Atenolol; Magnesium; Thyroid TAB; Vitamin B Complex CAP; Methyfolate; Estrogen Cream
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