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Triamterene and Hydrochlorothiazide (Triamterene / Hydrochlorothiazide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Side effects observed in association with the use of triamterene and hydrochlorothiazide tablets, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:

Gastrointestinal:  jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.

Central Nervous System:  drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.

Cardiovascular:  tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).

Renal:  acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.

Hematologic:  leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.

Ophthalmic:  xanthopsia, transient blurred vision.

Hypersensitivity:  anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.

Other:  muscle cramps and weakness, decreased sexual performance and sialadenitis.

Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.

Altered Laboratory Findings

Serum Electrolytes:  hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see WARNINGS and PRECAUTIONS).

Creatinine, Blood Urea Nitrogen:  Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with triamterene and hydrochlorothiazide.

Glucose:  hyperglycemia, glycosuria and diabetes mellitus (see PRECAUTIONS).

Serum Uric Acid, PBI and Calcium: (see PRECAUTIONS).

Other:  Elevated liver enzymes have been reported in patients receiving triamterene and hydrochlorothiazide.



REPORTS OF SUSPECTED TRIAMTERENE AND HYDROCHLOROTHIAZIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Triamterene and Hydrochlorothiazide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 69 year old female

Reported by a consumer/non-health professional from United States on 2011-10-11

Patient: 69 year old female weighing 66.7 kg (146.7 pounds)

Reactions: Headache, Amnesia, Arrhythmia, Paraesthesia, Generalised Oedema, Product Measured Potency Issue, Sinus Headache, Alopecia, Unevaluable Event, Hypersomnia

Suspect drug(s):
Warfarin Sodium
    Dosage: 5 mg;qd;po
    Administration route: Oral
    Indication: Atrial Fibrillation
    Start date: 2007-01-01

Propranolol

Synthroid

Digoxin

Triamterene and Hydrochlorothiazide
    Dosage: 37.5 mg
    Indication: Fluid Retention
    Start date: 2006-01-01

Round-UP (NO Pref. Name)

Other drugs received by patient: Lanoxin; Vitamin D; Estrogen Cream; Atenolol; Methyfolate; Thyroid TAB; Vitamin B Complex CAP; Magnesium; Loratadine



Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 50 year old female

Reported by a consumer/non-health professional from United States on 2011-10-12

Patient: 50 year old female

Reactions: Pruritus Generalised, Arterial Occlusive Disease, Rash

Suspect drug(s):
Pradaxa
    Dosage: 300 mg
    Administration route: Oral
    Indication: Atrial Flutter
    Start date: 2011-08-02

Triamterene and Hydrochlorothiazide
    Indication: Diuretic Therapy
    End date: 2011-10-06

Other drugs received by patient: Vitamin TAB; Sotalol HCL



Possible Triamterene and Hydrochlorothiazide side effects / adverse reactions in 69 year old female

Reported by a consumer/non-health professional from United States on 2011-10-24

Patient: 69 year old female weighing 66.7 kg (146.7 pounds)

Reactions: Headache, Paraesthesia, Arrhythmia, Generalised Oedema, Product Measured Potency Issue, Sinus Headache, Alopecia, Unevaluable Event, Memory Impairment, Hypersomnia

Suspect drug(s):
Round-UP (NO Pref. Name)

Synthroid

Warfarin Sodium
    Dosage: 5 mg;qd;po
    Administration route: Oral
    Indication: Atrial Fibrillation
    Start date: 2007-01-01

Propranolol

Digoxin

Triamterene and Hydrochlorothiazide
    Dosage: 37.5 mg;
    Indication: Fluid Retention
    Start date: 2006-01-01

Other drugs received by patient: Lanoxin; Vitamin D; Loratadine; Atenolol; Magnesium; Thyroid TAB; Vitamin B Complex CAP; Methyfolate; Estrogen Cream



See index of all Triamterene and Hydrochlorothiazide side effect reports >>

Drug label data at the top of this Page last updated: 2014-04-24

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