Triaz (Benzoyl Peroxide Topical) - Description and Clinical Pharmacology

DESCRIPTION

TRIAZ^® (benzoyl peroxide) 3%, 6%, and 9% Gels, TRIAZ^® (benzoyl peroxide) 3%, 6%, and 9% Cleansers and TRIAZ^® (benzoyl peroxide) 3%, 6%, and 9% Pads are topical, gel-based, benzoyl peroxide containing preparations for use in the treatment of acne vulgaris. Benzoyl peroxide is an oxidizing agent that possesses antibacterial properties and is classified as a keratolytic. Benzoyl peroxide (C₁₄ H₁₀ O₄) is represented by the following chemical structure:

TRIAZ 3% Gel contains Hydrous Benzoyl Peroxide USP 3% as the active ingredient in a gel-based formulation consisting of: Purified Water USP, C12-15 Alkyl Benzoate, Glycerin USP, Cetyl Stearyl Alcohol, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, Glyceryl Stearate (and) PEG-100 Stearate, Steareth S-2, Steareth S-20, Dimethicone 200, Glycolic Acid, Zinc Lactate, Lactic Acid USP, Disodium EDTA USP, Sodium Hydroxide NF.

TRIAZ 6% and 9% Gels contain, respectively, Hydrous Benzoyl Peroxide USP 6% and 9% as the active ingredient in a gel-based formulation consisting of: Purified Water USP, C12-15 Alkyl Benzoate, Glycerin USP, Cetyl Stearyl Alcohol, Glycolic Acid, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, Glyceryl Stearate (and) PEG-100 Stearate, Steareth S-2, Sodium Hydroxide NF, Steareth S-20, Dimethicone 200, Zinc Lactate, Disodium EDTA USP.

TRIAZ 3% Cleanser contains Hydrous Benzoyl Peroxide USP 3% as the active ingredient in a vehicle consisting of: Glycerin USP, Petrolatum USP, C12-15 Alkyl Benzoate, Sodium Cocoyl Isethionate, Sodium C14-16 Olefin Sulfonate, Special Petrolatum Fraction, Zinc Lactate, Carbomer, Potassium Polymetaphosphate NF, Titanium Dioxide USP, Triethanolamine NF, Glycolic Acid, Lavender Extract, Menthol Crystals USP.

TRIAZ 6% and 9% Cleansers contain, respectively, Hydrous Benzoyl Peroxide USP 6% and 9% as the active ingredient in a vehicle consisting of: Glycerin USP, White Petrolatum USP, C12-15 Alkyl Benzoate, Sodium Cocoyl Isethionate, Special Petrolatum Fraction, Sodium C14-16 Olefin Sulfonate, Zinc Lactate, Carbomer, Potassium Polymetaphosphate NF, Titanium Dioxide USP, Triethanolamine NF, Glycolic Acid, Lavender Extract, Menthol Crystals USP.

TRIAZ 3%, 6% and 9% Pads contain, respectively, Hydrous Benzoyl Peroxide 3%, 6% and 9% as the active ingredient in a gel-based formulation consisting of: Purified Water USP, C12-15 Alkyl Benzoate NF, Glycerin 99% USP, Cetyl Stearyl Alcohol NF, Steareth S-2, Polysorbate 20 NF, Corn Starch Modified, Dimethicone NF, PEG 100 Stearate, Steareth S-20, Disodium EDTA USP, Glycolic Acid, Carbopol, Sodium Hydroxide NF, Zinc Lactate.

CLINICAL PHARMACOLOGY

The mechanism of action of benzoyl peroxide is not totally understood but its antibacterial activity against Propionibacterium acnes is thought to be a major mode of action. In addition, patients treated with benzoyl peroxide show a reduction in lipids and free fatty acids, and mild desquamation (drying and peeling activity) with simultaneous reduction in comedones and acne lesions. Little is known about the percutaneous penetration, metabolism, and excretion of benzoyl peroxide, although it has been shown that benzoyl peroxide absorbed by the skin is metabolized to benzoic acid and then excreted as benzoate in the urine. There is no evidence of systemic toxicity caused by benzoyl peroxide in humans.