ULTRAM ER SUMMARY
ULTRAM® ER (tramadol hydrochloride) is a centrally acting synthetic analgesic in an extended-release formulation.
ULTRAM ER is indicated for the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time.
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NEWS HIGHLIGHTSMedia Articles Related to Ultram ER (Tramadol)
The Opioid Crisis and Need for Compassion in Pain Management
Source: Medscape Anesthesiology Headlines [2017.09.28]
In this commentary, the author expresses concern that the response to the public health crisis of opioid addiction is creating a growing crisis of inadequate pain management.
American Journal of Public Health
CVS to Restrict Opioid Painkiller Prescription Amounts
Source: MedicineNet Drug Abuse Specialty [2017.09.25]
Title: CVS to Restrict Opioid Painkiller Prescription Amounts
Category: Health News
Created: 9/22/2017 12:00:00 AM
Last Editorial Review: 9/25/2017 12:00:00 AM
Stomach Pain Quiz: Nausea & Other Causes
Source: MedicineNet Anal Fissure Specialty [2017.09.19]
Title: Stomach Pain Quiz: Nausea & Other Causes
Category: MedicineNet Quiz
Created: 1/20/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:59:56 PM
Back Pain Quiz: Test Your Back Pain IQ
Source: MedicineNet Ankylosing Spondylitis Specialty [2017.09.19]
Title: Back Pain Quiz: Test Your Back Pain IQ
Category: MedicineNet Quiz
Created: 6/16/2011 3:41:00 PM
Last Editorial Review: 9/19/2017 6:39:04 PM
Pain Quiz: Test Your IQ of Pain
Source: MedicineNet Constipation Specialty [2017.09.19]
Title: Pain Quiz: Test Your IQ of Pain
Category: MedicineNet Quiz
Created: 7/14/2011 3:53:00 PM
Last Editorial Review: 9/19/2017 6:41:41 PM
Published Studies Related to Ultram ER (Tramadol)
Does the addition of tramadol and ketamine to ropivacaine prolong the axillary
brachial plexus block? [2014]
ropivacaine in brachial plexus anesthesia... CONCLUSION: We conclude that when added to brachial plexus analgesia at a dose of
Efficacy of extended-release tramadol for treatment of prescription opioid
withdrawal: a two-phase randomized controlled trial. [2013]
whether cessation of ER tramadol produces opioid withdrawal... CONCLUSIONS: ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid
Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain
relief during IUD insertion. [2012]
on pain during insertion of an intrauterine device (IUD)... CONCLUSION: Prophylactic analgesia using 50 mg tramadol and 550 mg naproxen,
Tramadol versus methadone for treatment of opiate withdrawal: a double-blind,
randomized, clinical trial. [2012]
The aim of this study was to compare the efficacy and safety of tramadol versus
methadone for treatment of opiate withdrawal. Seventy patients randomly were
assigned in two groups to receive either prescribed methadone (60 mg/day) or
tramadol (600 mg/day)... Tramadol may be as effective as methadone in the
control of withdrawal and could be considered as a potential substitute for
methadone to manage opioids withdrawal.
Comparison of peritonsillar infiltration effects of ketamine and tramadol on post
tonsillectomy pain: a double-blinded randomized placebo-controlled clinical
trial. [2012]
on post tonsillectomy pain and compare the side effects... CONCLUSION: Preoperative peritonsillar infiltration of tramadol can decrease
Clinical Trials Related to Ultram ER (Tramadol)
Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US, with over
530,000 procedures performed annually in children under 15 years (Baugh et al., 2011). The
postoperative period can be particularly painful. A recent clinical consensus acknowledges
there is no standard analgesic protocol, and calls for further research comparing
postoperative pain medications (Baugh et al., 2011). Tramadol was found to be as effective
as codeine with few reported side effects in a recent double-blinded, controlled trial
conducted by the investigators at Children's Hospitals and Clinics (CHC), and it is
currently being prescribed in the postoperative setting. However, despite its effectiveness
for pain control, there were some children that continued to report pain during the 10-day
follow-up period. In response, the investigators will conduct a randomized, double-blinded
controlled trial to determine whether or not adding scheduled gabapentin to a scheduled
tramadol + "as needed" (PRN) ibuprofen regimen provides better pain control than tramadol +
ibuprofen PRN alone during the post-tonsillectomy period. Using a 10-day take-home diary,
caregivers will be asked to record daily information about their child's postoperative pain
and other core outcomes and domains as recommended in the recent consensus statement put
forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical
Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with adding scheduled gabapentin to a postoperative
pain management protocol in a pediatric population.
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Completed]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
Hypotheses
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
The Effect of Escitalopram on the Pharmacokinetics and Pharmacodynamics of Tramadol in Healthy Subjects [Completed]
Escitalopram will be given to a panel of 16 healthy subject for 9 days. On the ninth day a
single dose of tramadol is administered to the subjects and pharmacokinetic(PK) and
pharmacodynamic(PD) measurements are done for the next 24 hours.
It is stated that escitalopram is only a weak inhibitor of CYP2D6 and therefore no effect is
seen in Pk or PK of tramadol
A Pharmacokinetic Study to Evaluate the Dose-Proportionality of Tramadol (ULTRAM) Extended-Release (ER) in Healthy Participants [Completed]
The purpose of this study is to evaluate the dose proportionality of the pharmacokinetics
(explores what the body does to the drug) of tramadol in healthy adult participants.
A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers [Completed]
The purpose of this study is to determine the safety and tolerability profile of tramadol
hydrochloride (HCl) given as oral doses every 6 hours, within the range of dosages supported
by currently available toxicology and clinical data (200 mg to 600 mg per day).
Reports of Suspected Ultram ER (Tramadol) Side Effects
Drug Ineffective (5),
Hypersensitivity (3),
Pruritus (3),
Pain (3),
Skin Burning Sensation (3),
Myalgia (3),
Hypersomnia (3),
Arthralgia (3),
Drug Dose Omission (2),
Neck Pain (2), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Ultram ER has an overall score of 5.50. The effectiveness score is 6 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst.
| | Ultram ER review by 29 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Cervical Disk Degeneration and Lower Back Pain |
| Dosage & duration: | | 50mg every 6 hrs as needed taken 2-3 times a day for the period of been taking for 2 weeks now. |
| Other conditions: | | Tinitus, Unable to sleep |
| Other drugs taken: | | Ambien | | |
Reported Results |
| Benefits: | | Ive been taking Tramadol for 2 weeks now. Ive been taking vicodin and percocuet for 7 months due to Cervial disk degeneration and lower back pain. I have to admit I loved taking Vicodin and percocuet. The problem is that they would knock me out. Tramadol has been awesome. It takes 90% of the pain away and I feel like I actually have energy again. From reading previous comments it sounds like I take a lower dose. Im really happy about that cause if I get use to it then I can up my dose and not feel worried about it. |
| Side effects: | | I have had no side effects so far. I hope it stays that way. |
| Comments: | | Treating for neck, shoulder, arms, lower back, hip, thigh and knee pain. |
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| | Ultram ER review by 34 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Pain relief from an infected cat bite wound |
| Dosage & duration: | | 200mg taken once daily for the period of 2 days |
| Other conditions: | | none |
| Other drugs taken: | | Levaquin, Promethazine | | |
Reported Results |
| Benefits: | | I was not able to ascertain any benefits from being treated with this medication. Its purpose was pain relief, and I did not experience any alleviation of my pain. |
| Side effects: | | I did not experience any side effects from taking this medication. |
| Comments: | | I was prescribed this medication after being seen by a doctor for a severely infected cat bite wound on the top of my left foot (which the doctor was concerned might become a systemic infection). The foot and my entire left leg were very painful (especially upon movement), so the doctor had me take Ultram ER to help relieve the pain. I was told to take 1 tablet daily as needed. I did as instructed for two consecutive days and did not have any relief from my pain. After I reported this to my doctor, she gave me a prescription for a stronger pain reliever (which did help). |
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Page last updated: 2017-09-28
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