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Vistaril (Hydroxyzine Pamoate) - Summary



VISTARIL (Hydroxyzine pamoate) is an antihistamine with sedative properties.

VISTARIL (HYDROXYZINE) is indicated for the following:

Hydroxyzine may potentiate meperidine (DemerolĀ®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.

The effectiveness of hydroxyzine as an antianxiety agent for long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.


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Published Studies Related to Vistaril (Hydroxyzine)

Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic dogs: a randomised, controlled, double-blinded trial. [2013]
Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs...

A preliminary randomised double-blind placebo-controlled clinical trial of hydroxyzine for treating sleep bruxism in children. [2013]
This is a randomised placebo-controlled clinical trial investigating the efficacy of hydroxyzine for treating parent-reported sleep bruxism in children. Participants of this trial were 30 patients randomly allocated to one of the two groups in a ratio of 1:2... Current evidence support that hydroxyzine is effective and well tolerated for treating bruxism in children.

Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers. [2011.06]
It is well known that the sedative properties of antihistamines can differ considerably between individual drugs... It is concluded that hydroxyzine-induced impairment at tmax is more prominent after morning doses compared with evening doses and that the present study could not present direct evidence to substantiate the hypothesis that histamine availability inversely affects the magnitude of antihistamine impairment.

[Effects of hydroxyzine on tolerance of facial mask during induction in children] [2010.01]
OBJECTIVE: To evaluate the effectiveness of hydroxyzine as a premedication agent for the acceptance of facial mask during induction of general anaesthesia in children... CONCLUSION: Hydroxyzine provided better acceptance of facial mask than placebo during induction of general anaesthesia in children. Copyright 2009 Elsevier Masson SAS. All rights reserved.

Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments. [2008.12]
Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, placebo (PLA)-controlled study... The 40-mg dose of BIL produced subjective report of sedation, whereas unwanted objective CNS side effects were observed only with the 80-mg dose.

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Reports of Suspected Vistaril (Hydroxyzine) Side Effects

Drug Ineffective (21)Depression (19)Anxiety (17)Fall (15)Emotional Disorder (15)Somnolence (12)Pain in Extremity (12)Suicide Attempt (10)Gait Disturbance (10)Hypertension (10)more >>


Based on a total of 1 ratings/reviews, Vistaril has an overall score of 1. The effectiveness score is 2 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst.

Vistaril review by 24 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   25mg taken every six hours for the period of 3 months
Other conditions:   anxiety
Other drugs taken:   CLONAZEPAM
Reported Results
Benefits:   I suffer from an anxiety disorder and have tried several medications. So far Clonazepam has helped me the best.
Side effects:   I would have anxiety attacts more often on Vistaril then any other medications. I have had no side effects from Clonazepam.
Comments:   I take the medication three times daily and I see a doctor once a week to see how I am doind as far as medications and to get therapy.

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Page last updated: 2014-11-30

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