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Xylocaine (Lidocaine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

XYLOCAINE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Overdosage of Xylocaine (lidocaine HCl Injection, USP) usually results in signs of central nervous system or cardiovascular toxicity (see ADVERSE REACTIONS ).

Should convulsions or signs of respiratory depression and arrest develop, the patency of the airway and adequacy of ventilation must be assured immediately.  Should convulsions persist despite ventilatory therapy with oxygen, small increments of anticonvulsive agents may be given intravenously.  Examples of such agents include a benzodiazepine (eg, diazepam), an ultrashort-acting barbiturate (eg, thiopental or thiamylal), or a short-acting barbiturate (eg, pentobarbital or secobarbital).  If the patient is under general anesthesia, a short-acting muscle relaxant (eg, succinylcholine) may be administered.

Should circulatory depression occur, vasopressors may be used.  Should cardiac arrest occur, standard CPR procedures should be instituted.

Dialysis is of negligible value in the treatment of acute overdosage from Xylocaine.

CONTRAINDICATIONS

Xylocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.  Xylocaine should not be used in patients with Stokes-Adams syndrome, Wolff-Parkinson-White syndrome, or with severe degrees of sinoatrial, atrioventricular, or intraventricular block in the absence of an artificial pacemaker.

DRUG ABUSE AND DEPENDENCE

Although specific studies have not been conducted, Xylocaine has been used clinically without evidence of abuse of this drug or of psychological or physical dependence as a result of its use.

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