Xylocaine (Lidocaine Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents.  Adverse experiences may result from high plasma levels caused by excessive dosage or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient.  Serious adverse experiences are generally systemic in nature.  The following types are those most commonly reported.  The adverse experiences under Central Nervous System and Cardiovascular System are listed, in general, in a progression from mild to severe.

Central Nervous System

CNS reactions are excitatory and/or depressant, and may be characterized by light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest.  The excitatory reactions may be very brief or may not occur at all, in which case, the first manifestation of toxicity may be drowsiness, merging into unconsciousness and respiratory arrest.

Cardiovascular System

Cardiovascular reactions are usually depressant in nature and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.

Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means.

REPORTS OF SUSPECTED XYLOCAINE SIDE EFFECTS / ADVERSE REACTIONS

Possible Xylocaine side effects / adverse reactions in 63 year old male

Reported by a physician from France on 2011-10-03

Patient: 63 year old male

Reactions: Shock

Adverse event resulted in: life threatening event

Suspect drug(s):
Xylocaine
    Start date: 2011-08-19
    End date: 2011-08-19

Celocurine
    Start date: 2011-08-19
    End date: 2011-08-19

Propofol
    Start date: 2011-08-19
    End date: 2011-08-19

Atropine
    Start date: 2011-08-19
    End date: 2011-08-19

Possible Xylocaine side effects / adverse reactions in 50 year old female

Reported by a physician from Germany on 2011-10-04

Patient: 50 year old female

Reactions: Thrombocytopenia, Uterine Haemorrhage, Haematoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Bupivacaine HCL
    Indication: Infiltration Anaesthesia
    Start date: 2011-01-31

Ciprofloxacin
    Administration route: Oral
    Indication: Upper Respiratory Tract Infection
    Start date: 2011-01-25
    End date: 2011-01-28

Levofloxacin
    Administration route: Oral
    Indication: Upper Respiratory Tract Infection
    Start date: 2011-01-17
    End date: 2011-01-24

Xylocaine
    Indication: Infiltration Anaesthesia
    Start date: 2011-01-31

Possible Xylocaine side effects / adverse reactions in 50 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-04

Patient: 50 year old female weighing 76.0 kg (167.2 pounds)

Reactions: Thrombocytopenia, Uterine Haemorrhage, Haematoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Levofloxacin
    Administration route: Oral
    Indication: Upper Respiratory Tract Infection
    Start date: 2011-01-17
    End date: 2011-01-24

Ciprofloxacin
    Administration route: Oral
    Indication: Upper Respiratory Tract Infection
    Start date: 2011-01-25
    End date: 2011-01-28

Xylocaine
    Indication: Infiltration Anaesthesia
    Start date: 2011-01-31

Bupivacaine HCL
    Indication: Infiltration Anaesthesia
    Start date: 2011-01-31