Zarontin (Ethosuximide) - Summary

ZARONTIN SUMMARY

Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.

See all Zarontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Zarontin (Ethosuximide)

Epilepsy & Seizures Quiz: What Causes Seizures?
Source: MedicineNet Seizure Specialty [2017.09.19]
Title: Epilepsy & Seizures Quiz: What Causes Seizures?
Category: MedicineNet Quiz
Created: 2/17/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:25:51 PM

Pot Compound Alters Levels of Seizure Drug in Epilepsy Patients
Source: MedicineNet Seizure Specialty [2017.08.14]
Title: Pot Compound Alters Levels of Seizure Drug in Epilepsy Patients
Category: Health News
Created: 8/11/2017 12:00:00 AM
Last Editorial Review: 8/14/2017 12:00:00 AM

Number of Americans With Epilepsy at Record Level
Source: MedicineNet Brain Tumor Specialty [2017.08.11]
Title: Number of Americans With Epilepsy at Record Level
Category: Health News
Created: 8/10/2017 12:00:00 AM
Last Editorial Review: 8/11/2017 12:00:00 AM

Seizure (Epilepsy)
Source: MedicineNet Canavan Disease Specialty [2017.05.10]
Title: Seizure (Epilepsy)
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 5/10/2017 12:00:00 AM

Marijuana Derivative May Curb Tough-to-Treat Epilepsy
Source: MedicineNet topiramate Specialty [2016.12.07]
Title: Marijuana Derivative May Curb Tough-to-Treat Epilepsy
Category: Health News
Created: 12/6/2016 12:00:00 AM
Last Editorial Review: 12/7/2016 12:00:00 AM

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Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

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Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4),  Drug Ineffective (3),  Poor Quality Drug Administered (3),  Atelectasis (2),  Pyrexia (2),  Mycoplasma Infection (2),  Abdominal Discomfort (2),  Stevens-Johnson Syndrome (2),  Oral Infection (2),  Toxic Epidermal Necrolysis (2), more >>