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Zarontin (Ethosuximide) - Side Effects and Adverse Reactions



Body As A Whole: Allergic reaction. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Gastrointestinal System: Gastrointestinal symptoms occur frequently and include anorexia, vague gastric upset, nausea and vomiting, cramps, epigastric and abdominal pain, weight loss, and diarrhea. There have been reports of gum hypertrophy and swelling of the tongue.

Hemopoietic System: Hemopoietic complications associated with the administration of ethosuximide have included leukopenia, agranulocytosis, pancytopenia, with or without bone marrow suppression, and eosinophilia.

Nervous System: Neurologic and sensory reactions reported during therapy with ethosuximide have included drowsiness, headache, dizziness, euphoria, hiccups, irritability, hyperactivity, lethargy, fatigue, and ataxia. Psychiatric or psychological aberrations associated with ethosuximide administration have included disturbances of sleep, night terrors, inability to concentrate, and aggressiveness. These effects may be noted particularly in patients who have previously exhibited psychological abnormalities. There have been rare reports of paranoid psychosis, increased libido, and increased state of depression with overt suicidal intentions.

Integumentary System: Dermatologic manifestations which have occurred with the administration of ethosuximide have included urticaria, pruritic erythematous rashes, and hirsutism.

Special Senses: Myopia.

Genitourinary System: Vaginal bleeding, microscopic hematuria.


Below is a sample of reports where side effects / adverse reactions may be related to Zarontin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Zarontin side effects / adverse reactions in 6 year old female

Reported by a physician from France on 2011-11-08

Patient: 6 year old female

Reactions: NO Adverse Event

Suspect drug(s):

Other drugs received by patient: Lamictal

Possible Zarontin side effects / adverse reactions in 73 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-23

Patient: 73 year old female

Reactions: Grand MAL Convulsion, Pyrexia, Muscle Disorder, Convulsion

Suspect drug(s):
    Dosage: unk
    Start date: 1964-01-01

    Dosage: unk
    Indication: Grand MAL Convulsion
    Start date: 1947-01-01

Possible Zarontin side effects / adverse reactions in 9 year old male

Reported by a pharmacist from United States on 2012-06-01

Patient: 9 year old male weighing 38.6 kg (84.8 pounds)

Reactions: Speech Disorder, Confusional State, Memory Impairment

Adverse event resulted in: disablity

Suspect drug(s):
    Dosage: 300mg -5ml- twice daily po
    Administration route: Oral
    Indication: Petit MAL Epilepsy
    Start date: 2010-02-10
    End date: 2012-05-31

    Dosage: 1150mg twice daily po
    Administration route: Oral
    Start date: 2011-08-13
    End date: 2012-05-31

See index of all Zarontin side effect reports >>

Drug label data at the top of this Page last updated: 2014-07-09

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