ZOMIG SUMMARY
ZOMIG® (zolmitriptan) Tablets and ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain zolmitriptan, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist.
ZOMIG is indicated for the acute treatment of migraine with or without aura in adults.
ZOMIG is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of ZOMIG have not been established for cluster headache, which is present in an older, predominantly male population.
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NEWS HIGHLIGHTSMedia Articles Related to Zomig (Zolmitriptan)
Pictures of Famous People Coping With Migraines
Source: MedicineNet Headache Specialty [2017.09.08]
Title: Pictures of Famous People Coping With Migraines
Category: Slideshows
Created: 11/5/2012 12:00:00 AM
Last Editorial Review: 9/8/2017 12:00:00 AM
Many Migraine Sufferers Given Unecessary Opioids, Study Finds
Source: MedicineNet Headache Specialty [2017.08.28]
Title: Many Migraine Sufferers Given Unecessary Opioids, Study Finds
Category: Health News
Created: 8/25/2017 12:00:00 AM
Last Editorial Review: 8/28/2017 12:00:00 AM
Migraine vs. Headache: Differences and Similarities
Source: MedicineNet Analgesics, Antipyretics Specialty [2017.06.26]
Title: Migraine vs. Headache: Differences and Similarities
Category: Diseases and Conditions
Created: 6/21/2017 12:00:00 AM
Last Editorial Review: 6/26/2017 12:00:00 AM
Migraine
Source: MedicineNet amitriptyline Specialty [2017.05.22]
Title: Migraine
Category: Symptoms and Signs
Created: 2/27/2015 12:00:00 AM
Last Editorial Review: 5/22/2017 12:00:00 AM
Migraine Headache
Source: MedicineNet Antiphospholipid Syndrome Specialty [2017.03.13]
Title: Migraine Headache
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 3/13/2017 12:00:00 AM
Published Studies Related to Zomig (Zolmitriptan)
Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan. [2011.05]
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain condition, associated with substantial disability. Aim of this study was to compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment of MRM attacks, analyzing data from a multicenter, randomized, double blind, cross-over study...
Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan. [2011.02]
BACKGROUND: Endpoints used to evaluate the efficacy of acute anti-migraine drugs do not measure the tolerability. Sustained pain-free response with no adverse events has been recommended as a composite endpoint which measures the efficacy and tolerability attributes that patients desire... CONCLUSION: Composite efficacy-plus-tolerability endpoints may be useful for facilitating comparisons between treatments.
Efficacy of frovatriptan in the acute treatment of menstrually related migraine:
analysis of a double-blind, randomized, multicenter, Italian, comparative study
versus zolmitriptan. [2011]
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain
condition, associated with substantial disability. Aim of this study was to
compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment
of MRM attacks, analyzing data from a multicenter, randomized, double blind,
cross-over study...
Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study. [2010.06]
The objective of this study is to assess patients' satisfaction with migraine treatment with frovatriptan (F) or zolmitriptan (Z), by preference questionnaire. 133 subjects with a history of migraine with or without aura (IHS criteria) were randomized to F 2.5 mg or Z 2.5 mg... In conclusion, our study suggests that F has a similar efficacy of Z, with some advantage as regards tolerability and recurrence.
Frovatriptan versus zolmitriptan for the acute treatment of migraine: a
double-blind, randomized, multicenter, Italian study. [2010]
The objective of this study is to assess patients' satisfaction with migraine
treatment with frovatriptan (F) or zolmitriptan (Z), by preference questionnaire. 133 subjects with a history of migraine with or without aura (IHS criteria) were
randomized to F 2.5 mg or Z 2.5 mg... In
conclusion, our study suggests that F has a similar efficacy of Z, with some
advantage as regards tolerability and recurrence.
Clinical Trials Related to Zomig (Zolmitriptan)
Determine Central 5-HT1B Receptor Occupancy of ZOMIG� Rapimelt (Zolmitriptan) in Healthy Male Volunteers [Completed]
Zomig - Treatment of Acute Migraine Headache in Adolescents [Completed]
The purpose of this study is to investigate if Zomig® Nasal Spray will help children (age
12-17 years) with migraine headaches feel better. This will be done by comparing 3 different
doses of Zomig Nasal Spray with placebo nasal spray (inactive treatment).
Efficacy of Zolmitriptan (Zomig) in the Treatment of Migraines in Adolescents [Completed]
The purpose of this study is to evaluate the effectiveness and safety of Zolmitriptan
(Zomig) nasal spray, 5. 0 mg, compared with placebo (inactive drug) for 2 migraine headaches
over a 3-month period in adolescent patients (aged 12 to 17 years) with migraine headaches
Efficacy and Tolerability of Zolmitriptan Nasal Spray [Completed]
The purpose of this study is to evaluate the effectiveness and tolerability (the ability not
to experience ill effects from the study drug) of a zolmitriptan nasal spray, 5. 0 mg,
compared with placebo (inactive drug) for 2 migraine headaches for up to 12 weeks in adult
subjects with migraine headaches
Zolmitriptan Nasal Spray Versus Eletriptan in the Acute Treatment of Migraine [Completed]
The purpose of this study is to Compare the efficacy of zolmitriptan 5 mg nasal spray vs.
eletriptan 40 mg tablet in the acute treatment of migraine.
To develop and evaluate a set of importance weights for a predefined set of treatment
attributes for migraine suffers using zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg
tablet.
To contrast the efficacy of zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet at
early time points.
To analyze the patterns of self-reported tolerability of migraine sufferers using
zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet.
Reports of Suspected Zomig (Zolmitriptan) Side Effects
Migraine (245),
Drug Dose Omission (162),
Headache (112),
Malaise (76),
Drug Ineffective (48),
Intentional Drug Misuse (42),
Vomiting (36),
Pain (29),
Feeling Abnormal (25),
Nausea (18), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 20 ratings/reviews, Zomig has an overall score of 8.20. The effectiveness score is 8.60 and the side effect score is 7.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Zomig review by 50 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Migraine |
| Dosage & duration: | | 2.5mg taken max x2 per migraine attack for the period of indefinitely |
| Other conditions: | | nausea |
| Other drugs taken: | | domperidone for the nausea | | |
Reported Results |
| Benefits: | | allowed me to function rather than having to spend 2-3 days in bed |
| Side effects: | | mild initial discomfort in the neck |
| Comments: | | Prescribed for migraine relief |
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| | Zomig review by 40 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | migraine |
| Dosage & duration: | | 2.5 mg rapimelt taken 4x/month on average for the period of 4 years |
| Other conditions: | | hypertension |
| Other drugs taken: | | hydrochlorothiazide 12.5 mg/day | | |
Reported Results |
| Benefits: | | Within minutes, migraine disappears 98% of the time. If I wait too long to take medication, it reduces the chances of eliminating the migraine. Without Zomig, I would have a lot of sick days from work. |
| Side effects: | | I feel sleepy but I would rather feel this way than to edure the pain of a migraine. |
| Comments: | | Taken PRN, only prescribed 6 tabs every 20 days |
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| | Zomig review by care giver of 50 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Migraine |
| Dosage & duration: | | 2.5 ml 2 pills taken once for the period of only once She died same day |
| Other conditions: | | liver problems, diabetes, high blood pressure, lung problems |
| Other drugs taken: | | norco, methodone, blood pressure medicine, plus a few more | | |
Reported Results |
| Benefits: | | The medicine did not work on her head ache--she had it all day long. |
| Side effects: | | Sharon complained of severe chest pain from the pills around 8:30 at night. She was also on a lot of other medications and I think the combination of medicines put her into heart attack and she passed away. |
| Comments: | | She took one pill at the Doctors office and she took one home to take. She died some time that night. I think it was too much medication and combination of different medicines. I miss her so much. July 17, 2009 |
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Page last updated: 2017-09-08
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