This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Acyclovir and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (349)
Death (45)
Life Threatening Events (32)
Disability (5)
Reports by Reaction Type
Oedema (32),
Hepatotoxicity (31),
Vomiting (30),
Nausea (28),
Rash (28),
Drug Interaction (25),
Malaise (25),
Pyrexia (24),
Palmar-Plantar Erythrodysaesthesia Syndrome (23),
Blood Bilirubin Increased (22),
Skin Toxicity (22),
Renal Failure Acute (22)
Below are a few examples of reports where side effects / adverse reactions may be related to Acyclovir. For a complete list or a specific selection of reports, please use the links above.
Possible Acyclovir side effects in 61 year old female
Reported by a physician from Germany on 2012-08-27
Patient: 61 year old female, weighing 70.0 kg (154.0 pounds)
Reactions: Hepatotoxicity, Presyncope
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Acyclovir
Dosage: 400 milligram
Allopurinol
Dosage: 300 milligram
Clopidogrel Bisulfate
Dosage: 75 milligram
Indication: Prophylaxis
Dexamethasone
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-02-24
End date: 2011-03-17
Dexamethasone
Dosage: 40 milligram
Administration route: Oral
Start date: 2011-03-10
End date: 2011-03-17
Enalapril Maleate
Dosage: 10 milligram
Pantoprazole
Dosage: 40 milligram
Revlimid
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-02-24
End date: 2011-03-16
Torsemide
Dosage: 10 milligram
Indication: Hypertension
Other drugs received by patient: Amitriptyline HCL; Trimethoprim + Sulfamethoxazole; Valoron; Amitriptyline Hydrochloride; Lyrica; Enoxaparin Sodium; Moviprep; Soventol Gel; Folsan; Morphine; Morphine; Valoron; Cotrim DS
Possible Acyclovir side effects in female
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-23
Patient: female
Reactions: Agitation, Self Injurious Behaviour
Drug(s) suspected as cause:
Acyclovir
Indication: Product Used FOR Unknown Indication
Lormetazepam
Indication: Product Used FOR Unknown Indication
Possible Acyclovir side effects in female
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-22
Patient: female
Reactions: Self Injurious Behaviour, Nervousness
Drug(s) suspected as cause:
Acyclovir
Dosage: unk
Indication: Product Used FOR Unknown Indication
Lormetazepam
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Acyclovir side effects in female
Reported by a pharmacist from France on 2012-08-22
Patient: female
Reactions: Ear Discomfort, Deafness
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in 73 year old female
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: 73 year old female, weighing 90.7 kg (199.6 pounds)
Reactions: Incoherent, Renal Failure, Hallucination, Blood Pressure Decreased, Hypersomnia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Other drugs received by patient: Adderall; Wellbutrin SR
Possible Acyclovir side effects in 61 year old female
Reported by a health professional (non-physician/pharmacist) from Spain on 2012-08-21
Patient: 61 year old female
Reactions: Neurotoxicity, Dysarthria, Psychotic Disorder, Hallucination, Visual
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in 66 year old male
Reported by a health professional (non-physician/pharmacist) from Spain on 2012-08-21
Patient: 66 year old male
Reactions: Dysarthria, Neurotoxicity, Depressed Level of Consciousness
Drug(s) suspected as cause:
Acyclovir
Dosage: 400 mg, bid
Acyclovir
Dosage: 200 mg, daily
Indication: Herpes Zoster
Valacyclovir Hydrochloride
Dosage: 500 mg, bid
Administration route: Oral
Indication: Herpes Zoster
Possible Acyclovir side effects in female
Reported by a physician from Italy on 2012-08-20
Patient: female
Reactions: Suicidal Behaviour, Mental Disorder
Drug(s) suspected as cause:
Acyclovir
Dosage: 2400 milligram daily;
Administration route: Oral
Start date: 2012-06-27
End date: 2012-06-27
Aspirin
Dosage: 2500 milligram daily;
Administration route: Oral
Start date: 2012-06-27
End date: 2012-06-27
Minias
Dosage: exact drop number taken is unknown
Administration route: Oral
Start date: 2012-06-27
End date: 2012-06-27
Possible Acyclovir side effects in 57 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16
Patient: 57 year old female, weighing 60.3 kg (132.7 pounds)
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Acyclovir
Dosage: 1 tab 3 times a day po days
Administration route: Oral
Indication: Oral Herpes
Start date: 2012-08-11
End date: 2012-08-11
Acyclovir
Dosage: 1 tab 3 times a day po days
Administration route: Oral
Indication: Oral Herpes
Start date: 2012-07-17
End date: 2012-07-19
Possible Acyclovir side effects in 46 year old female
Reported by a pharmacist from United States on 2012-08-16
Patient: 46 year old female, weighing 111.0 kg (244.2 pounds)
Reactions: Drug Prescribing Error, Renal Failure Acute
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in 32 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-16
Patient: 32 year old female, weighing 68.0 kg (149.6 pounds)
Reactions: Abortion Missed, Pregnancy
Adverse event resulted in: death
Drug(s) suspected as cause:
Acyclovir
Dosage: 800 mg
Administration route: Oral
Indication: Antiviral Prophylaxis
Start date: 2003-04-29
Combivir
Dosage: 1 df, qd
Administration route: Oral
Indication: HIV Infection
Start date: 2003-05-29
Efavirenz
Dosage: 600 mg, qd
Administration route: Oral
Indication: HIV Infection
Start date: 2003-05-29
Septra
Dosage: 480 mg, qd
Administration route: Oral
Indication: Antifungal Prophylaxis
Start date: 2003-04-29
End date: 2009-08-04
Possible Acyclovir side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-15
Patient: female, weighing 98.9 kg (217.5 pounds)
Reactions: Nausea, Headache, Product Physical Issue
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in
Reported by a physician from Germany on 2012-08-15
Patient:
Reactions: Fungal Infection
Adverse event resulted in: death
Drug(s) suspected as cause:
Acyclovir
Indication: Antiviral Prophylaxis
Revlimid
Administration route: Oral
Indication: Multiple Myeloma
Other drugs received by patient: Ciprofloxacin; Fluconazole; Posaconazole
Possible Acyclovir side effects in 61 year old female
Reported by a health professional (non-physician/pharmacist) from Spain on 2012-08-14
Patient: 61 year old female
Reactions: Dysarthria, Neurotoxicity, Psychotic Disorder, Hallucination, Visual
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in 29 year old male
Reported by a physician from Singapore on 2012-08-13
Patient: 29 year old male
Reactions: Angioedema, Anaphylactic Reaction, Urticaria, Hypotension
Drug(s) suspected as cause:
Acyclovir
Indication: Product Used FOR Unknown Indication
Ceftriaxone
Indication: Product Used FOR Unknown Indication
Flagyl
Indication: Product Used FOR Unknown Indication
Toradol
Indication: Product Used FOR Unknown Indication
Possible Acyclovir side effects in 63 year old female
Reported by a health professional (non-physician/pharmacist) from Hong Kong on 2012-08-09
Patient: 63 year old female
Reactions: Blood Pressure Increased, Haemoglobin Decreased, Toxic Encephalopathy, Haemodialysis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Dosage: (400 mg qid oral)
Administration route: Oral
Indication: Herpes Zoster
Acyclovir
Dosage: (5 % 5x/day topical)
Administration route: Topical
Indication: Herpes Zoster
Other drugs received by patient: Aspirin; Metoprolol Tartrate; Alfacalcidol; Calcium Carbonate; Epogen; Diltiazem HCL
Possible Acyclovir side effects in 87 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 87 year old male, weighing 75.0 kg (165.0 pounds)
Reactions: Blood Urea Increased, Blood Creatinine Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Possible Acyclovir side effects in 68 year old female
Reported by a physician from United Kingdom on 2012-08-09
Patient: 68 year old female
Reactions: Liver Function Test Abnormal
Drug(s) suspected as cause:
Acyclovir
Administration route: Oral
Indication: Oral Herpes
Start date: 2012-03-15
End date: 2012-03-22
Fluconazole
Administration route: Oral
Indication: Candidiasis
Start date: 2012-03-15
End date: 2012-03-22
Omeprazole
Administration route: Oral
Indication: Gastric Disorder
Start date: 2012-03-15
Velcade
Indication: Chemotherapy
Start date: 2012-03-15
Other drugs received by patient: Dexamethasone Sodium Phosphate; Oxycodone HCL; Calceos; Moviprep; Allopurinol
Possible Acyclovir side effects in 73 year old male
Reported by a consumer/non-health professional from United States on 2012-08-08
Patient: 73 year old male
Reactions: Dysphagia, International Normalised Ratio Increased, General Physical Health Deterioration, Erosive Oesophagitis, Rash, International Normalised Ratio Fluctuation
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Acyclovir
Indication: Herpes Simplex
Start date: 2012-06-07
End date: 2012-06-18
Clindamycin
Indication: Herpes Simplex
Start date: 2012-06-07
End date: 2012-06-18
Coumadin
Dosage: 7.5mg unknown
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-07
Valtrex
Dosage: 500mg twice per day
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-17
End date: 2012-06-23
Other drugs received by patient: Zovirax; Digoxin; Prednisone TAB; Bactroban; Amiodarone HCL; Omeprazole
Possible Acyclovir side effects in 45 year old male
Reported by a physician from United States on 2012-08-08
Patient: 45 year old male
Reactions: Electrocardiogram QT Prolonged, Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Indication: Prophylaxis
Cytarabine
Dosage: 200 mg/m2, cyclic, (total dose 43.02 mg)
Indication: Acute Myeloid Leukaemia
Start date: 2011-12-24
Cytarabine
Dosage: 200 mg/m2, cyclic, (total dose 44.46 g)
Start date: 2012-05-30
Daunorubicin HCL
Dosage: 60 mg/m2, cyclic, (total 5 courses of therapy)
Indication: Acute Myeloid Leukaemia
Start date: 2011-12-24
Fluconazole
Indication: Prophylaxis
Piperacillin
Indication: Prophylaxis
Sprycel
Dosage: 50 mg, cyclic, (total dose 1800 mg)
Start date: 2012-03-19
Sprycel
Dosage: 100 mg, cyclic, (total dose 2100 mg)
Start date: 2012-05-30
Sprycel
Dosage: 100 mg, cyclic
Administration route: Oral
Indication: Acute Myeloid Leukaemia
Start date: 2011-12-24
Possible Acyclovir side effects in 63 year old female
Reported by a health professional (non-physician/pharmacist) from Hong Kong on 2012-08-08
Patient: 63 year old female
Reactions: Haemoglobin Decreased, Blood Pressure Increased, Toxic Encephalopathy, Mental Status Changes, Stupor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Dosage: 400 mg / four times per day / oral
Administration route: Oral
Indication: Herpes Zoster
Zovirax
Dosage: fve times per day / topical
Administration route: Topical
Indication: Herpes Zoster
Other drugs received by patient: Metoprolol Tartrate; Alfacalcidol; Diltiazem HCL; Epogen; Aspirin; Calcium Carbonate
Possible Acyclovir side effects in 71 year old female
Reported by a physician from Germany on 2012-08-08
Patient: 71 year old female
Reactions: Exfoliative Rash
Drug(s) suspected as cause:
Acyclovir
Dosage: 800 milligram
Administration route: Oral
Indication: Prophylaxis
Start date: 2011-05-20
End date: 2011-05-31
Cotrim DS
Administration route: Oral
Indication: Prophylaxis
Start date: 2011-05-20
End date: 2011-05-31
Dexamethasone
Dosage: 40 milligram
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-05-20
Revlimid
Dosage: 25 milligram
Administration route: Oral
End date: 2011-06-28
Revlimid
Dosage: 25 milligram
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-05-20
End date: 2011-06-03
Other drugs received by patient: Polyethylene Glycol; Enoxaparin Sodium; Morphine; Metamizole
Possible Acyclovir side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-08
Patient: male
Reactions: Asthma, Headache, Gastric Ulcer, Fatigue, Neuropathy Peripheral, Depression, Myocardial Infarction, Pneumonia, Haemorrhoids, Acquired Immunodeficiency Syndrome, Hernia, Cerebrovascular Accident, Cushing's Syndrome, Bronchitis Chronic, Epididymitis, Cardiac Arrest
Drug(s) suspected as cause:
Acyclovir
Albuterol Sulfate and Ipratropium Bromide
Dosage: 3/5 mg three times a day
Aspirin
Bupropion Hydrochloride
Bystolic
Crestor
Administration route: Oral
Fluorouracil
Dosage: every 12 hours
Folic Acid
Fosamax
Isentress
Lasix
Dosage: 40 mg daily and as needed
MAG Oxide Cypress
Multi-Vitamin
Dosage: daily
Neurontin
Dosage: 300 mg three times a day as needed
Norvir
Oxegen
Dosage: 2 liters while sleeping and as needed
Plavix
Prezista
Prilosec
Administration route: Oral
Prochlorperazine
Spironolactone
Testosterone
Vitamin D
Possible Acyclovir side effects in 87 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-08
Patient: 87 year old male
Reactions: Diarrhoea, Bone Lesion, Conjunctivitis Infective, Skin Lesion, Keratitis Viral, Erythema, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Dosage: 10 mg/kg, 3x/day
Indication: Herpes Zoster Ophthalmic
Start date: 2012-05-06
End date: 2012-05-09
Lasix
Dosage: 40 mg, 2x/day
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-05-09
Pyostacine
Dosage: unk
Administration route: Oral
Indication: Skin Lesion
Start date: 2012-05-06
Ramipril
Dosage: 2.5 mg, daily
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-05-09
Other drugs received by patient: Bisoprolol; Valaciclovir; Tobrex; NEO-Mercazole TAB; Previscan; Allopurinol; Potassium Chloride; Zovirax
Possible Acyclovir side effects in 59 year old male
Reported by a health professional (non-physician/pharmacist) from Spain on 2012-08-08
Patient: 59 year old male
Reactions: Fungaemia, Pneumonia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Dosage: 1600 mg
Cotrim
Cyclosporine
Levofloxacin
Dosage: 500 mg
Administration route: Oral
Indication: Pneumonia
Prednisone TAB
Voriconazole
Dosage: 400 mg
Administration route: Oral
Indication: Prophylaxis
Possible Acyclovir side effects in 80 year old male
Reported by a health professional (non-physician/pharmacist) from Hong Kong on 2012-08-08
Patient: 80 year old male
Reactions: Dyspnoea, Malaise, Vomiting, Dehydration, Encephalitis, Mental Status Changes, General Physical Health Deterioration, Stupor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Other drugs received by patient: Aspirin; Chloramphenicol; Allopurinol; Chlorpheniramine Maleate; Isosorbide Dinitrate
Possible Acyclovir side effects in male
Reported by a physician from Italy on 2012-08-07
Patient: male
Reactions: Confusional State, Blood Urea Increased, Bradykinesia, Ataxia, Hypokinesia, Overdose, Blood Creatinine Increased, Bradyphrenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Other drugs received by patient: Zantac; Cordarone; Valium; Calcium Carbonate; Altiazem; Coumadin; Leucovorin Calcium
Possible Acyclovir side effects in male
Reported by a physician from Italy on 2012-08-07
Patient: male
Reactions: Confusional State, Overdose, Hypokinesia, Ataxia, Bradyphrenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
Other drugs received by patient: Coumadin; Cordarone; Altiazem; Zantac; Calcium Carbonate; Leucovorin Calcium; Valium
Possible Acyclovir side effects in 68 year old female
Reported by a individual with unspecified qualification on 2012-08-07
Patient: 68 year old female
Reactions: Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased, Protein Total Increased
Drug(s) suspected as cause:
Acyclovir
Dosage: 400 mg, oral
Administration route: Oral
Indication: Oral Herpes
Start date: 2012-03-15
End date: 2012-03-22
Fluconazole
Dosage: 50 mg, oral
Administration route: Oral
Indication: Candidiasis
Start date: 2012-03-15
End date: 2012-03-22
Omeprazole
Dosage: 20 mg, oral
Administration route: Oral
Indication: Gastric Disorder
Start date: 2012-03-15
Velcade
Dosage: intravenous
Indication: Chemotherapy
Other drugs received by patient: Oxycodone HCL; Allopurinol; Dexamethasone Sodium Phosphate; Movicol (Nulytely / 01053601 / ); Calceos (Lekovit CA)
Possible Acyclovir side effects in female
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-07
Patient: female
Reactions: Abdominal Pain, Haematemesis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acyclovir
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