This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Cytoxan (Cyclophosphamide) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (180)
Death (30)
Life Threatening Events (9)
Disability (7)
Reports by Reaction Type
Pyrexia (15),
Neuropathy Peripheral (11),
Febrile Neutropenia (11),
Pancytopenia (11),
Respiratory Disorder (9),
Fall (9),
Neutropenia (9),
Asthenia (8),
Off Label Use (7),
Vomiting (7),
Dyspnoea (7),
Anaemia (7)
Below are a few examples of reports where side effects / adverse reactions may be related to Cytoxan (Cyclophosphamide). For a complete list or a specific selection of reports, please use the links above.
Possible Cytoxan side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: , weighing 2.5 kg (5.4 pounds)
Reactions: Foetal Growth Restriction, Foetal Exposure During Pregnancy
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage III
Cytoxan
Indication: Breast Cancer Stage III
Paclitaxel
Indication: Breast Cancer Stage III
Possible Cytoxan side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: , weighing 2.1 kg (4.7 pounds)
Reactions: Hyperbilirubinaemia
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage II
Cytoxan
Indication: Breast Cancer Stage II
Paclitaxel
Indication: Breast Cancer Stage II
Possible Cytoxan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: female
Reactions: Premature Rupture of Membranes, Maternal Exposure During Pregnancy, Uterine Contractions During Pregnancy
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage I
Cytoxan
Indication: Breast Cancer Stage I
Paclitaxel
Indication: Breast Cancer Stage I
Possible Cytoxan side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: , weighing 1.9 kg (4.3 pounds)
Reactions: Foetal Growth Restriction
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage I
Cytoxan
Indication: Breast Cancer Stage I
Fluorouracil
Indication: Breast Cancer Stage I
Paclitaxel
Indication: Breast Cancer Stage I
Possible Cytoxan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: female
Reactions: Maternal Exposure During Pregnancy, PRE-Eclampsia
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage II
Cytoxan
Indication: Breast Cancer Stage II
Paclitaxel
Indication: Breast Cancer Stage II
Possible Cytoxan side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: , weighing 2.4 kg (5.3 pounds)
Reactions: Neutropenia Neonatal, Pyloric Stenosis
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage III
Cytoxan
Indication: Breast Cancer Stage III
Docetaxel
Indication: Breast Cancer Stage III
Paclitaxel
Indication: Breast Cancer Stage III
Possible Cytoxan side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: , weighing 1.4 kg (3.1 pounds)
Reactions: Selective IGA Immunodeficiency, Neonatal Respiratory Distress Syndrome, Premature Baby, Gastrooesophageal Reflux Disease, Apnoea, Constipation
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage II
Cytoxan
Indication: Breast Cancer Stage II
Paclitaxel
Indication: Breast Cancer Stage II
Possible Cytoxan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: female
Reactions: Maternal Exposure During Pregnancy, Uterine Contractions During Pregnancy
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage I
Cytoxan
Indication: Breast Cancer Stage I
Fluorouracil
Indication: Breast Cancer Stage I
Paclitaxel
Indication: Breast Cancer Stage I
Possible Cytoxan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: female
Reactions: Maternal Exposure During Pregnancy, PRE-Eclampsia
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage II
Cytoxan
Indication: Breast Cancer Stage II
Paclitaxel
Indication: Breast Cancer Stage II
Possible Cytoxan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: female
Reactions: Pneumocystis Jiroveci Pneumonia, Maternal Exposure During Pregnancy, Neutropenia, Premature Labour
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Stage II
Cytoxan
Indication: Breast Cancer Stage II
Paclitaxel
Indication: Breast Cancer Stage II
Possible Cytoxan side effects in 57 year old female
Reported by a individual with unspecified qualification from United States on 2012-08-22
Patient: 57 year old female
Reactions: Hypogammaglobulinaemia
Drug(s) suspected as cause:
Cytoxan
Indication: T-Cell Lymphoma
Rituximab
Indication: T-Cell Lymphoma
Other drugs received by patient: Tacrolimus; Azathioprine Sodium; Bexarotene; Alemtuzumab; Alemtuzumab
Possible Cytoxan side effects in female
Reported by a physician from United States on 2012-08-06
Patient: female
Reactions: Breast Cancer, Asthenia
Drug(s) suspected as cause:
Adriamycin PFS
Indication: Breast Cancer Metastatic
Cytoxan
Indication: Breast Cancer Metastatic
Herceptin
Indication: Breast Cancer Metastatic
Possible Cytoxan side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-03
Patient: male
Reactions: Back Pain, Death
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Cytoxan
Dosage: 1620 mg, cyclic
Indication: Multiple Myeloma
Start date: 2011-09-08
End date: 2011-09-08
Dexamethasone
Dosage: 40 mg, cyclic
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-09-08
End date: 2011-10-13
Velcade
Dosage: 2 mg, cyclic
Indication: Multiple Myeloma
Start date: 2011-09-08
End date: 2011-10-05
Possible Cytoxan side effects in
Reported by a physician from Israel on 2012-07-28
Patient:
Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Ondansetron HCL
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Ondansetron HCL
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Post Trial Therapy
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Post Trial Therapy
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded PRE Trial Therapy
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded PRE Trial Therapy
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Cisplatin
Dosage: 46.2 mg/kg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-18
Cytoxan
Dosage: 172 mg, qd
Indication: Chemotherapy
Start date: 2012-06-19
End date: 2012-06-20
Dexamethasone
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Dexamethasone
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Etoposide
Dosage: 33 mg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-20
Ondansetron
Administration route: Oral
Indication: Prophylaxis of Nausea and Vomiting
Start date: 2012-06-18
End date: 2012-06-22
Placebo
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Placebo
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Vincristine Sulfate
Dosage: 0.6 mg, qd
Start date: 2012-06-24
End date: 2012-06-24
Vincristine Sulfate
Dosage: 0.66 mg, qd
Start date: 2012-07-01
End date: 2012-07-01
Vincristine Sulfate
Dosage: 0.66 mg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-18
Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Mesna; Resprim; Diamox
Possible Cytoxan side effects in male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-19
Patient: male, weighing 76.0 kg (167.2 pounds)
Reactions: Hypothyroidism
Drug(s) suspected as cause:
Cytoxan
Other drugs received by patient: Laxoberon; Lendormin; Zithromax; Sennoside A+B Calcium; Loxoprofen; Amaryl; Brocin-Codeine
Possible Cytoxan side effects in
Reported by a physician from Israel on 2012-07-17
Patient:
Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Aprepitant
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Ondansetron HCL
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded Ondansetron HCL
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Post Trial Therapy
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded Post Trial Therapy
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Blinded PRE Trial Therapy
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Blinded PRE Trial Therapy
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Cisplatin
Dosage: 46.2 mg/kg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-18
Cytoxan
Dosage: 172 mg, qd
Indication: Chemotherapy
Start date: 2012-06-19
End date: 2012-06-20
Dexamethasone
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Dexamethasone
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Etoposide
Dosage: 33 mg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-20
Ondansetron
Administration route: Oral
Indication: Prophylaxis of Nausea and Vomiting
Start date: 2012-06-18
End date: 2012-06-22
Placebo
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Placebo
Administration route: Oral
Start date: 2012-06-18
End date: 2012-06-18
Vincristine Sulfate
Dosage: 0.66 mg, qd
Indication: Chemotherapy
Start date: 2012-06-18
End date: 2012-06-18
Vincristine Sulfate
Dosage: 0.6 mg, qd
Start date: 2012-06-24
End date: 2012-06-24
Vincristine Sulfate
Dosage: 0.66 mg, qd
Start date: 2012-07-01
End date: 2012-07-01
Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Resprim; Diamox; Mesna
Possible Cytoxan side effects in
Reported by a physician from United States on 2012-07-16
Patient:
Reactions: Small Intestinal Obstruction
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytoxan
Administration route: Oral
Indication: Amyloidosis
Dexamethasone
Administration route: Oral
Indication: Amyloidosis
Lenalidomide
Administration route: Oral
Indication: Amyloidosis
Possible Cytoxan side effects in
Reported by a individual with unspecified qualification from United States on 2012-07-16
Patient:
Reactions: Multi-Organ Failure, Sepsis
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytoxan
Administration route: Oral
Indication: Amyloidosis
Dexamethasone
Administration route: Oral
Indication: Amyloidosis
Lenalidomide
Administration route: Oral
Indication: Amyloidosis
Possible Cytoxan side effects in
Reported by a individual with unspecified qualification from United States on 2012-07-06
Patient:
Reactions: Renal Failure
Adverse event resulted in: death
Drug(s) suspected as cause:
Bortezomib
Indication: Multiple Myeloma
Bortezomib
Cytoxan
Administration route: Oral
Indication: Multiple Myeloma
Dexamethasone
Indication: Multiple Myeloma
Lenalidomide
Indication: Multiple Myeloma
Possible Cytoxan side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-29
Patient: male, weighing 128.1 kg (281.8 pounds)
Reactions: Musculoskeletal Pain, Anaemia, Mental Status Changes, Multiple Myeloma, Hypercalcaemia, Osteonecrosis, Fatigue, Gait Disturbance, Thrombocytopenia, Pathological Fracture
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Cytoxan
Dexamethasone
Indication: Product Used FOR Unknown Indication
Etoposide
Indication: Product Used FOR Unknown Indication
Revlimid
Indication: Product Used FOR Unknown Indication
Velcade
Dosage: unk
Start date: 2012-05-03
Velcade
Dosage: 1.3 mg, cyclic
Indication: Multiple Myeloma
Start date: 2012-03-07
End date: 2012-04-23
Other drugs received by patient: Metoprolol Succinate; Ramipril; Duloxetime Hydrochloride; Glucophage; Catapres / 00171101 /; Allopurinol; Cymbalta; Percocet; Zometa; Ativan; Ascriptin A / D
Possible Cytoxan side effects in
Reported by a individual with unspecified qualification from United States on 2012-06-28
Patient:
Reactions: Vasculitis Cerebral
Drug(s) suspected as cause:
Bortezomib
Indication: non-Hodgkin's Lymphoma
Cytoxan
Administration route: Oral
Indication: non-Hodgkin's Lymphoma
Rituximab
Indication: non-Hodgkin's Lymphoma
[pss Gpn] Dexamethasone Solution FOR Infusion Dosette Vial 4 MG
Administration route: Oral
Indication: non-Hodgkin's Lymphoma
Possible Cytoxan side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-06-28
Patient: 63 year old male
Reactions: Fungal Infection, Bone Marrow Failure
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytoxan
Start date: 2011-06-07
End date: 2011-06-07
Solu-Medrol
Start date: 2011-06-03
End date: 2011-06-06
Solu-Medrol
Start date: 2011-06-07
Possible Cytoxan side effects in male
Reported by a consumer/non-health professional from United States on 2012-06-26
Patient: male, weighing 227.0 kg (499.4 pounds)
Reactions: Osteoarthritis, Neuropathy Peripheral, Peroneal Nerve Palsy, Obesity, Fall
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cytoxan
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2012-03-06
Decadron
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2012-03-06
Velcade
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2012-03-06
Other drugs received by patient: Zovirax; Zometa; Palonosetron
Possible Cytoxan side effects in male
Reported by a physician from Ireland on 2012-06-25
Patient: male, weighing 70.0 kg (154.0 pounds)
Reactions: Confusional State, Aphasia, Urinary Incontinence, Hemiparesis, Cerebrovascular Accident, Multi-Organ Failure, Dysarthria, Respiratory Failure, Nervous System Disorder, Asthenia, Progressive Multifocal Leukoencephalopathy, Decreased Appetite
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Colchicine
Indication: Product Used FOR Unknown Indication
Cytoxan
Administration route: Oral
Indication: Rheumatoid Vasculitis
Cytoxan
Administration route: Oral
End date: 2007-08-01
Plaquenil
Indication: Product Used FOR Unknown Indication
Plaquenil
Prednisone
Indication: Vasculitis
Prednisone
Remicade
Indication: Rheumatoid Arthritis
End date: 2007-08-01
Remicade
Indication: Vasculitis
End date: 2007-08-01
Other drugs received by patient: Flecainide Acetate; Atenolol; Lasix; Theo-DUR; Aspirin; Hytrin; Restoril; Potassium Acetate
Possible Cytoxan side effects in 51 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-25
Patient: 51 year old male
Reactions: Osteoarthritis, Neuropathy Peripheral, Peroneal Nerve Palsy, Musculoskeletal Pain, Obesity, Fall, Paraesthesia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cytoxan
Dosage: 900 mg, 1/week
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2011-12-13
Decadron
Dosage: 40 mg, 1/week
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2011-12-13
Velcade
Dosage: 3.5 mg, 1/week
Indication: Multiple Myeloma
Start date: 2011-03-29
End date: 2011-12-13
Possible Cytoxan side effects in 77 year old male
Reported by a physician from United States on 2012-06-21
Patient: 77 year old male
Reactions: Mycobacterium Kansasii Infection, Pulmonary Mass
Drug(s) suspected as cause:
Cytoxan
Indication: Wegener's Granulomatosis
Remicade
Indication: Wegener's Granulomatosis
Other drugs received by patient: Rituxan; Prednisone TAB; Methotrexate
Possible Cytoxan side effects in 24 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-15
Patient: 24 year old female
Reactions: Cognitive Disorder
Drug(s) suspected as cause:
Adriamycin PFS
Dosage: no of cycles 4
Indication: Breast Cancer
Cytoxan
Dosage: no of cycles 4
Indication: Breast Cancer
Taxol
Dosage: no of cycles 4
Indication: Breast Cancer
Possible Cytoxan side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-06-15
Patient: 63 year old male
Reactions: Fungal Infection, Bone Marrow Failure
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytoxan
Start date: 2011-06-07
End date: 2011-06-07
Solu-Medrol
Start date: 2011-06-07
Solu-Medrol
Start date: 2011-06-03
End date: 2011-06-06
Possible Cytoxan side effects in 70 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-13
Patient: 70 year old male
Reactions: Renal Failure, Tumour Lysis Syndrome
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Cytoxan
Indication: Lymphoma
Matulane
Dosage: 50 mg; bid; po
Administration route: Oral
Indication: Lymphoma
Start date: 2012-05-04
Rituxan
Indication: Lymphoma
Vincristine
Indication: Lymphoma
Possible Cytoxan side effects in 74 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-08
Patient: 74 year old male, weighing 90.3 kg (198.7 pounds)
Reactions: Cystitis Noninfective
Drug(s) suspected as cause:
Cytoxan
Dosage: 600 mg/m2, on day 1 of each cycle
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-01-23
End date: 2012-04-17
Pentostatin
Dosage: 4 mg/m2, on day 1 of each cycle
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-01-23
End date: 2012-04-17
Rituximab
Dosage: 100 mg, day 1, 375 mg/m2 day 3 and 5, and days 1 of week 5,9,13,17 and 21
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-01-23
End date: 2012-04-17
Other drugs received by patient: Acyclovir; Digoxin; Actos; Spiriva; Amiloride HCL and Hydrochlorothiazide; Lipitor; Multiple Vitamins
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