This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Dilantin (Phenytoin) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (761)
Death (37)
Life Threatening Events (11)
Disability (43)
Reports by Reaction Type
Convulsion (190),
Stevens-Johnson Syndrome (147),
Drug Ineffective (43),
Amnesia (41),
Anticonvulsant Drug Level Decreased (40),
Dizziness (39),
Headache (37),
Anticonvulsant Drug Level Increased (36),
Malaise (33),
Pain (31),
Fall (30),
Tremor (26)
Below are a few examples of reports where side effects / adverse reactions may be related to Dilantin (Phenytoin). For a complete list or a specific selection of reports, please use the links above.
Possible Dilantin side effects in 38 year old male
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 38 year old male, weighing 98.4 kg (216.5 pounds)
Reactions: Weight Decreased, Pain, Hepatic Failure, Headache, Somnolence, Myalgia, Weight Increased, Overdose, Malaise, Fatigue, Musculoskeletal Stiffness, Depression, Swelling, Nervous System Disorder, Feeling Abnormal, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: unk
Indication: Convulsion
Ibuprofen
Dosage: 4000 mg in a day
Indication: Headache
Lyrica
Dosage: 300 mg, 3x/day
Administration route: Oral
Indication: Convulsion
Lyrica
Dosage: 100 mg, 3x/day
Administration route: Oral
Start date: 2012-06-01
Lyrica
Dosage: 300 mg, 2x/day
Administration route: Oral
End date: 2012-06-01
Other drugs received by patient: Morphine; Hydrocodone; Lamictal; Butalbital
Possible Dilantin side effects in 54 year old female
Reported by a pharmacist from United States on 2012-08-24
Patient: 54 year old female
Reactions: Capsule Physical Issue, Poor Quality Drug Administered, Feeling Abnormal
Drug(s) suspected as cause:
Dilantin
Dosage: unk
Administration route: Oral
Dilantin
Dosage: 100 mg, unk
Administration route: Oral
Indication: Convulsion
Start date: 1981-01-01
Other drugs received by patient: Depakene
Possible Dilantin side effects in 21 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 21 year old female, weighing 59.0 kg (129.8 pounds)
Reactions: Abortion Spontaneous
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in 82 year old female
Reported by a lawyer from United States on 2012-08-24
Patient: 82 year old female, weighing 54.0 kg (118.8 pounds)
Reactions: Blood Urea Increased, Decubitus Ulcer, Dehydration, Blood Creatinine Increased
Drug(s) suspected as cause:
Dilantin
Dosage: 100 mg, 3x/day (every 8 hours)
Start date: 2011-03-19
End date: 2011-03-24
Dilantin
Dosage: 100mg/2ml every 8 hours
Start date: 2011-03-19
Dilantin
Dosage: 750 mg, unk
Start date: 2011-03-19
Dilantin
Dosage: 100 mg, 2x/day
Administration route: Oral
Indication: Convulsion
Start date: 2011-03-13
Dilantin-125
Dosage: 125mg/ 5ml
Administration route: Oral
Indication: Convulsion
Start date: 2011-03-21
End date: 2011-03-24
Other drugs received by patient: Potassium Chloride; Norvasc; Colace; Prilosec; Aricept; Ativan; Heparin; Levaquin; Neurontin; Cozaar; Vitamin D; Cerebyx; Ferrous Sulfate
Possible Dilantin side effects in 32 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 32 year old female, weighing 58.9 kg (129.6 pounds)
Reactions: Abortion Spontaneous
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in 50 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 50 year old female, weighing 59.0 kg (129.7 pounds)
Reactions: Pruritus, Vomiting, Nasopharyngitis, Anticonvulsant Drug Level Decreased, Convulsion, Malaise, Balance Disorder, Transient Ischaemic Attack, Ear Congestion, Feeling Abnormal, Sluggishness, Blister, Influenza
Drug(s) suspected as cause:
Dilantin
Dosage: unk
Administration route: Oral
Indication: Epilepsy
End date: 2012-08-01
Phenytoin
Dosage: unk
Indication: Epilepsy
Start date: 2011-12-01
Other drugs received by patient: Lipitor; Topamax; Simvastatin; Aspirin
Possible Dilantin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: female
Reactions: Dental Discomfort
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: male
Reactions: Drug Ineffective
Drug(s) suspected as cause:
Dilantin
Dosage: 2 capsules of 100 mg in the morning and 3 capsules of 100 mg in the evening(2x/day)
Administration route: Oral
Indication: Convulsion
Start date: 2008-01-01
Keppra
Dosage: unk
Indication: Convulsion
Start date: 2007-01-01
End date: 2012-02-02
Possible Dilantin side effects in 64 year old male
Reported by a physician from United States on 2012-08-24
Patient: 64 year old male, weighing 83.0 kg (182.6 pounds)
Reactions: Drug Dose Omission, Drug Ineffective, Convulsion
Drug(s) suspected as cause:
Depakote
Dosage: 500 mg, 2x/day
Indication: Epilepsy
Dilantin
Dosage: 100 mg, unk
Dilantin
Dosage: 100 mg, 3x/day
Indication: Epilepsy
Phenytoin Sodium
Dosage: unk
Possible Dilantin side effects in 26 year old female
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: 26 year old female, weighing 59.0 kg (129.7 pounds)
Reactions: Abortion Spontaneous
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient:
Reactions: Bedridden, Emphysema, Off Label Use, Lung Disorder, Amnesia, Chronic Obstructive Pulmonary Disease
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Aspirin
Dosage: 81 mg, prn
Indication: Chest Pain
Atenolol
Dosage: 25 mg, qd
Administration route: Oral
Indication: Hypertension
Ativan
Dosage: 1 mg, tid
Administration route: Oral
Indication: Nervousness
Atropine Sulfate
Dosage: 2.5 mg, qid
Administration route: Oral
Indication: Crohn's Disease
Depakote
Dosage: 500 mg, bid
Administration route: Oral
Indication: Convulsion
Dilantin
Dosage: 300 mg, bid
Administration route: Oral
Indication: Convulsion
Furosemide
Dosage: 40 mg, bid
Administration route: Oral
Indication: Diuretic Therapy
Generlac
Dosage: 30 mg, prn
Indication: Crohn's Disease
Humulin R
Dosage: 24 units
Indication: Diabetes Mellitus
Imdur
Dosage: 30 mg, tid
Indication: Cardiac Disorder
Lantus
Dosage: 80 units in the moring and 90 units at night
Indication: Diabetes Mellitus
Lantus
Dosage: unk
Methocarbamol
Indication: Neuropathy Peripheral
Methocarbamol
Dosage: 750 mg, prn
Administration route: Oral
Indication: Muscle Spasms
Nitrostat
Dosage: 0.4 mg, prn
Indication: Chest Pain
Norvasc
Administration route: Oral
Indication: Palpitations
Potassium Chloride
Potassium Chloride (KV / 24)
Dosage: 8 meq, qd
Indication: Blood Potassium
Remeron
Dosage: 30 mg, qd
Administration route: Oral
Indication: Insomnia
Tylenol
Dosage: unk unk, qd
Indication: Migraine
Zantac
Dosage: 30 mg, tid
Administration route: Oral
Indication: Gastrooesophageal Reflux Disease
Zocor
Dosage: 40 mg, qd
Administration route: Oral
Possible Dilantin side effects in 56 year old male
Reported by a physician from United States on 2012-08-23
Patient: 56 year old male, weighing 90.7 kg (199.5 pounds)
Reactions: Drug Ineffective, Mental Disability, Depression
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Other drugs received by patient: Carvedilol
Possible Dilantin side effects in female
Reported by a pharmacist from Canada on 2012-08-23
Patient: female
Reactions: Drug Level Fluctuating, Wrong Technique in Drug Usage Process, Incorrect Dose Administered, Convulsion
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in 48 year old female
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: 48 year old female, weighing 59.0 kg (129.7 pounds)
Reactions: Carotid Artery Thrombosis, Blood Cholesterol Increased
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in 36 year old female
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: 36 year old female, weighing 61.2 kg (134.7 pounds)
Reactions: Speech Disorder, Pain, Nervous System Disorder, Memory Impairment, Epilepsy
Drug(s) suspected as cause:
Depakote
Dosage: 500 mg, 2x/day
Administration route: Oral
Indication: Epilepsy
Start date: 2009-01-01
Dilantin
Dosage: 200mg in morning and 300mg at night
Administration route: Oral
Indication: Epilepsy
Start date: 2011-01-15
Neurontin
Neurontin
Dosage: unk, 3x/day
Administration route: Oral
Start date: 2003-01-01
Neurontin
Indication: Migraine
Neurontin
Dosage: 100 mg, 3x/day
Administration route: Oral
Indication: Nerve Injury
Start date: 2007-01-01
Other drugs received by patient: Percocet; Topamax; Amitriptyline; Amitriptyline; Estradiol
Possible Dilantin side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-22
Patient:
Reactions: Bedridden, Emphysema, Amnesia, Chronic Obstructive Pulmonary Disease
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Aspirin
Atenolol
Administration route: Oral
Ativan
Administration route: Oral
Depakote
Administration route: Oral
Dilantin
Administration route: Oral
Furosemide
Administration route: Oral
Generlac
Humulin R
Isosorbide Mononitrate
Lantus
Dosage: 80 iu, qam
Lantus
Dosage: 90 df, qpm
Lomotil
Administration route: Oral
Methocarbamol
Administration route: Oral
Nitrostat
Norvasc
Administration route: Oral
Potassium Chloride
Remeron
Administration route: Oral
Tylenol W / Codeine NO. 3
Zantac
Zocor
Administration route: Oral
Possible Dilantin side effects in
Reported by a physician from India on 2012-08-22
Patient:
Reactions: Drug Ineffective, Anticonvulsant Drug Level Decreased, Ataxia
Drug(s) suspected as cause:
Dilantin
Dosage: 1 ml, 2x/day
Administration route: Oral
Indication: Convulsion
Start date: 2012-01-01
Phenytoin Sodium
Indication: Convulsion
Possible Dilantin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: female, weighing 95.3 kg (209.7 pounds)
Reactions: Adverse Drug Reaction, Headache, Toxicity To Various Agents, Drug Level, Stress, Convulsion, Emotional Distress, Depressed Level of Consciousness, Bronchitis, Cervix Carcinoma, Influenza
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Indication: Convulsion
End date: 2011-01-01
Klonopin
Administration route: Oral
Indication: Convulsion
Other drugs received by patient: Excedrin (United States); Laxatives (Unk Ingredients); Albuterol; Nexium; Bentyl; Bentyl; Phenergan HCL; Bentyl; Bentyl; Phenergan HCL; Nexium; Symbicort; Benadryl
Possible Dilantin side effects in 62 year old male
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: 62 year old male, weighing 86.2 kg (189.6 pounds)
Reactions: Hypoaesthesia Oral, Somnolence, Feeling Drunk, Tremor
Drug(s) suspected as cause:
Dilantin
Dosage: 100 mg, 4x/day
Administration route: Oral
Indication: Grand MAL Convulsion
Start date: 1966-01-01
End date: 2012-08-15
Phenytoin
Dosage: 100 mg, 4x/day
Indication: Grand MAL Convulsion
Start date: 2012-08-16
Other drugs received by patient: Phenobarbital; Primidone
Possible Dilantin side effects in 39 year old female
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: 39 year old female, weighing 61.0 kg (134.2 pounds)
Reactions: Pain, Convulsion
Drug(s) suspected as cause:
Dilantin
Dosage: 200mg in morning and 300mg at night chewable tablets in a day
Administration route: Oral
Indication: Convulsion
Start date: 2011-01-01
Dilantin
Indication: Epilepsy
Neurontin
Dosage: unk, 3x/day
Administration route: Oral
Indication: Nerve Injury
Start date: 2003-01-01
Neurontin
Indication: Migraine
Other drugs received by patient: Topamax; Estradiol; Topamax; Amitriptyline
Possible Dilantin side effects in 10 year old female
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: 10 year old female
Reactions: Toxicity To Various Agents
Drug(s) suspected as cause:
Dilantin
Possible Dilantin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: male
Reactions: Drug Ineffective
Drug(s) suspected as cause:
Dilantin
Dosage: 2 capsules of 100 mg in the morning and 3 capsules of 100 mg in the evening(2x/day)
Administration route: Oral
Indication: Convulsion
Start date: 2008-01-01
Keppra
Dosage: unk
Indication: Convulsion
Start date: 2007-01-01
End date: 2012-02-02
Possible Dilantin side effects in 74 year old female
Reported by a pharmacist from United States on 2012-08-21
Patient: 74 year old female, weighing 119.0 kg (261.8 pounds)
Reactions: Drug Ineffective
Drug(s) suspected as cause:
Dilantin
Other drugs received by patient: Synthroid
Possible Dilantin side effects in 47 year old male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: 47 year old male, weighing 71.2 kg (156.6 pounds)
Reactions: Accident, Drug Level Increased, Pain, Injury, Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: 100 mg, 4x/day
Administration route: Oral
Dilantin
Dosage: 100 mg, 3x/day
Administration route: Oral
Indication: Convulsion
Keppra
Dosage: 250 mg, 2x/day
Indication: Convulsion
Start date: 2012-01-01
Possible Dilantin side effects in 62 year old male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: 62 year old male, weighing 93.0 kg (204.6 pounds)
Reactions: Peripheral Coldness, Back Pain, Neuropathy Peripheral, Arthritis, Intervertebral Disc Compression
Drug(s) suspected as cause:
Dilantin
Dosage: 200 mg, 2x/day
Administration route: Oral
Indication: Ill-Defined Disorder
Dilantin Kapseal
Dosage: 100 mg, 1x/day
Administration route: Oral
Indication: Convulsion
Dilantin Kapseal
Indication: Epilepsy
Other drugs received by patient: Acetylsalicylic Acid; Phenobarbital TAB; Doxazosin Mesylate; Naproxen; Finasteride; Enalapril Maleate
Possible Dilantin side effects in 49 year old female
Reported by a lawyer from United States on 2012-08-20
Patient: 49 year old female, weighing 81.0 kg (178.2 pounds)
Reactions: Dermatitis Allergic, Cellulitis, Eye Irritation, Conjunctivitis, Pain, Toxic Epidermal Necrolysis, Death, Eye Swelling, Stevens-Johnson Syndrome, Deep Vein Thrombosis, Blister
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: unk
Administration route: Oral
Start date: 2007-03-01
End date: 2007-05-01
Dilantin
Dosage: 100 mg, 3x/day
Administration route: Oral
Start date: 2007-03-14
End date: 2007-03-29
Other drugs received by patient: Vinblastine; Cisplatin; Temodar
Possible Dilantin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-20
Patient: male, weighing 71.2 kg (156.6 pounds)
Reactions: Headache, Hypoaesthesia, Malaise, Palpitations, Anticonvulsant Drug Level Increased, Pollakiuria, Compulsive LIP Biting, Feeling Abnormal
Drug(s) suspected as cause:
Dilantin
Dosage: 100 mg, unk
Administration route: Oral
Dilantin
Dosage: 100 mg, 4x/day
Administration route: Oral
Dilantin
Dosage: 100 mg, 3x/day
Administration route: Oral
Indication: Convulsion
Possible Dilantin side effects in 41 year old female
Reported by a lawyer from United States on 2012-08-20
Patient: 41 year old female
Reactions: Stevens-Johnson Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: 300 mg, 1x/day at bed time
Administration route: Oral
Indication: Convulsion
Start date: 2008-12-28
Dilantin
Dosage: 300 mg, at bedtime
Administration route: Oral
Start date: 2009-01-24
Dilantin
Dosage: 300 mg, (100mg capsule orally in the morning and 100mg 2 capsules at bed time)
Administration route: Oral
Start date: 2009-01-03
Dilantin
Dosage: 100 mg, unk
Administration route: Oral
Start date: 2009-01-02
Dilantin
Dosage: 1000 mg, unk
Start date: 2009-01-03
Possible Dilantin side effects in 34 year old male
Reported by a physician from United States on 2012-08-20
Patient: 34 year old male, weighing 124.0 kg (272.8 pounds)
Reactions: Stevens-Johnson Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: 200 mg, 2x/day
Indication: Convulsion Prophylaxis
Start date: 2011-01-20
End date: 2011-01-20
Dilantin
Dosage: 500 mg, unk
Administration route: Oral
Start date: 2011-01-24
End date: 2011-01-24
Dilantin
Dosage: 200 mg, 2x/day
Administration route: Oral
Start date: 2011-01-21
End date: 2011-01-26
Dilantin
Dosage: 100 mg, 3x/day
Administration route: Oral
Start date: 2011-01-27
End date: 2011-02-10
Other drugs received by patient: Benadryl; Insulin; Decadron Phosphate; Prilosec; Protonix; Hydromorphone; Vancomycin; Morphine; Tylenol; Maxipime; Paxil; Norco; Hydroxyzine
Possible Dilantin side effects in 51 year old female
Reported by a pharmacist from United States on 2012-08-17
Patient: 51 year old female, weighing 63.5 kg (139.7 pounds)
Reactions: Product Formulation Issue, Urticaria
Drug(s) suspected as cause:
Dilantin
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