This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Heparin and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (451)
Death (126)
Life Threatening Events (68)
Disability (19)
Reports by Reaction Type
Heparin-Induced Thrombocytopenia (79),
Thrombocytopenia (34),
Haemorrhage (29),
Dyspnoea (24),
Cerebral Haemorrhage (23),
Pyrexia (21),
Pulmonary Embolism (20),
Gastrointestinal Haemorrhage (15),
Thrombosis in Device (15),
Nausea (15),
Haemoglobin Decreased (15),
Deep Vein Thrombosis (15)
Below are a few examples of reports where side effects / adverse reactions may be related to Heparin. For a complete list or a specific selection of reports, please use the links above.
Possible Heparin side effects in 18 year old female
Reported by a physician from Slovenia on 2012-08-23
Patient: 18 year old female
Reactions: Pulmonary Haemorrhage, Gastrointestinal Haemorrhage, Injection Site Haemorrhage, Sepsis, Shock Haemorrhagic, Acute Respiratory Distress Syndrome, Bone Marrow Failure, Staphylococcal Bacteraemia, Septic Shock
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Doxorubicin HCL
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Heparin
Vincristine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Possible Heparin side effects in
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: , weighing 122.6 kg (269.7 pounds)
Reactions: Atelectasis, Tinnitus, Contusion, Haemorrhage, Rectal Haemorrhage, Bundle Branch Block Right, Chronic Obstructive Pulmonary Disease, Viith Nerve Paralysis, Colonic Fistula, Hypoxia, Blood Testosterone Decreased, Unevaluable Event, Spinal Laminectomy, Cervical Spinal Stenosis, Transient Ischaemic Attack, Oxygen Saturation Decreased, White Blood Cell Count Increased, Vomiting, Cataract, Bone Graft, Gout, Atrial Fibrillation, Precancerous Cells Present, Anal Fissure, Gastrointestinal Pain, Platelet Count Decreased, Sleep Apnoea Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Heparin
Indication: Contusion
Humira
Humira
Indication: Psoriatic Arthropathy
Other drugs received by patient: Astepro; Albuterol; Furosemide; Levothyroxine Sodium; Oxygen; Magnesium with Zinc; Diovan; Aspirin; Sertraline Hydrochloride; Fish OIL; Fluticasone Propionate; Methotrexate; Cholcyrs; Allegra; Triamcinolone; Hydrocodone; Alprazolam; Calcium with D; Fluticasone Propionate; Zirtec D; Alprazolam; Vitamin E; Lidex Gel; Naproxen; Diltiazem; Allegra-D 12 Hour; Spiriva; Metoprolol Tartrate; Sertraline Hydrochloride; Mens Multi Vitamin; Cetirizine HCL; Flax Seed; Ascorbic Acid
Possible Heparin side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-22
Patient: female
Reactions: Blood Pressure Increased, Dyspnoea, Flatulence, Peritoneal Dialysis Complication, Weight Increased, Abdominal Distension, Umbilical Hernia, Feeling Abnormal, Cardiac Arrest
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dianeal
Start date: 2009-07-19
End date: 2009-07-28
Dianeal
Indication: Peritoneal Dialysis
Dianeal LOW Calcium W / Dextrose 1.5%
Indication: Peritoneal Dialysis
Heparin
Vancomycin
Possible Heparin side effects in female
Reported by a health professional (non-physician/pharmacist) from Finland on 2012-08-22
Patient: female
Reactions: Cerebral Haemorrhage
Adverse event resulted in: death
Drug(s) suspected as cause:
Alteplase
Dosage: 5 mg + 0.5 mg/hr
Indication: Thrombolysis
Start date: 2010-01-01
End date: 2010-01-01
Enoxaparin Sodium
Enoxaparin Sodium
Indication: Thrombolysis
Start date: 2010-01-01
End date: 2010-01-01
Heparin
Indication: Product Used FOR Unknown Indication
Start date: 2010-01-01
End date: 2010-01-01
Warfarin Sodium
Indication: Product Used FOR Unknown Indication
Possible Heparin side effects in
Reported by a pharmacist from United States on 2012-08-20
Patient:
Reactions: Haemorrhage, Coagulation Time Abnormal
Drug(s) suspected as cause:
Heparin
Dosage: unk
Heparin Sodium
Dosage: unk
Possible Heparin side effects in 88 year old female
Reported by a physician from Japan on 2012-08-16
Patient: 88 year old female
Reactions: Cardiac Failure, Heparin-Induced Thrombocytopenia, Renal Failure Chronic, Anti-Neutrophil Cytoplasmic Antibody Positive Vasculitis
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Azulfidine
Dosage: 500 mg/day
Administration route: Oral
Indication: Rheumatoid Arthritis
End date: 2011-11-07
Heparin
Dosage: unk
Possible Heparin side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-15
Patient: male
Reactions: Abdominal Wall Haematoma, Metabolic Acidosis, Compartment Syndrome, Neutrophilia
Adverse event resulted in: death
Drug(s) suspected as cause:
Heparin
Warfarin Sodium
Possible Heparin side effects in 79 year old male
Reported by a pharmacist from United States on 2012-08-14
Patient: 79 year old male, weighing 86.0 kg (189.2 pounds)
Reactions: Heparin-Induced Thrombocytopenia, Atrial Flutter, Atrial Fibrillation
Drug(s) suspected as cause:
Heparin
Possible Heparin side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-14
Patient: 80 year old female
Reactions: Heparin-Induced Thrombocytopenia, Embolism, Diverticular Perforation
Adverse event resulted in: death
Drug(s) suspected as cause:
Anastrozole
Administration route: Oral
Indication: Breast Cancer Metastatic
Fulvestrant
Dosage: 500mg on day1, and 250mg on day 14 and 28, and thereafter every 28 days
Indication: Breast Cancer Metastatic
Heparin
Indication: Breast Cancer Metastatic
Possible Heparin side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-13
Patient: male
Reactions: Abdominal Pain, Metabolic Acidosis, Urine Output Decreased, Tachycardia, Neutrophilia, Pallor, Abdominal Compartment Syndrome, Abdominal Tenderness, Abdominal Wall Haematoma, Blood Creatinine Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Heparin
Heparin
Warfarin Sodium
Possible Heparin side effects in 66 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-13
Patient: 66 year old male
Reactions: Thrombotic Microangiopathy
Adverse event resulted in: death
Drug(s) suspected as cause:
Albumin
Dosage: form: solution
End date: 2012-03-06
Bactrim DS
Administration route: Oral
End date: 2012-03-22
Delursan
Administration route: Oral
Indication: Cholestasis
End date: 2012-05-11
Effexor
Administration route: Oral
Start date: 2012-03-13
End date: 2012-03-22
Folic Acid
Administration route: Oral
Indication: Vitamin B12 Deficiency
End date: 2012-04-05
Heparin
End date: 2012-03-21
Levothyroxine Sodium
Administration route: Oral
Indication: Hypothyroidism
End date: 2012-05-11
Nicardipine HCL
Administration route: Oral
Indication: Hypertension
End date: 2012-04-15
Omeprazole
Administration route: Oral
End date: 2012-05-11
Phenoxymethyl Penicillin
Dosage: 2 millions iu daily
End date: 2012-03-22
Plitican
Start date: 2012-03-14
End date: 2012-03-19
Sandimmune
Start date: 2012-01-23
End date: 2012-04-04
Solu-Medrol
Indication: Immunosuppression
End date: 2012-05-11
Tiorfan
Administration route: Oral
End date: 2012-04-25
Tranxene
Administration route: Oral
Start date: 2012-03-13
End date: 2012-03-16
Valganciclovir
Administration route: Oral
Start date: 2012-03-10
End date: 2012-03-16
Vfend
Dosage: powder for solution for perfusion
End date: 2012-05-11
Zolpidem Tartrate
Administration route: Oral
Indication: Insomnia
End date: 2012-03-18
Possible Heparin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-10
Patient: female
Reactions: Osteoporosis, Multiple Fractures
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Albuterol
Indication: Product Used FOR Unknown Indication
Fluticasone Propionate
Indication: Product Used FOR Unknown Indication
Heparin
Indication: Thrombosis Prophylaxis
Steroids
Indication: Product Used FOR Unknown Indication
Possible Heparin side effects in 70 year old male
Reported by a physician from Japan on 2012-08-10
Patient: 70 year old male, weighing 70.3 kg (154.7 pounds)
Reactions: Haematochezia, Hepatic Function Abnormal, Haemorrhagic Cerebral Infarction, Cardiac Failure Acute, Cardiogenic Shock, Acute Myocardial Infarction
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Aspirin
Dosage: 100 mg
Indication: Myocardial Infarction
End date: 2012-06-22
Heparin
End date: 2012-06-22
Plavix
Dosage: 75 mg
Indication: Myocardial Infarction
End date: 2012-06-22
Pradaxa
Dosage: 220 mg
Start date: 2012-06-01
End date: 2012-06-22
Pradaxa
Dosage: 300 mg
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2011-11-01
End date: 2012-06-22
Other drugs received by patient: Lansoprazole; Dobupum; Cefotiam Hydrochloride; Hanp; Lasix; Amiodarone Hydrochloride; Fentanyl; Lipitor; Soldactone; Milrinone Lactate; Diprivan
Possible Heparin side effects in 85 year old female
Reported by a pharmacist from United States on 2012-08-10
Patient: 85 year old female, weighing 78.0 kg (171.6 pounds)
Reactions: Thrombocytopenia, Epistaxis
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Eptifibatide
Dosage: iv drip
Indication: Acute Myocardial Infarction
Heparin
Dosage: 1290 units/hr iv drip
Possible Heparin side effects in 68 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 68 year old male, weighing 109.6 kg (241.1 pounds)
Reactions: Thrombocytopenia, Deep Vein Thrombosis
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Heparin
Possible Heparin side effects in 67 year old female
Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-08-07
Patient: 67 year old female
Reactions: Hyperphosphataemia, Bursitis
Drug(s) suspected as cause:
Heparin
Possible Heparin side effects in male
Reported by a physician from United States on 2012-08-07
Patient: male, weighing 48.7 kg (107.1 pounds)
Reactions: Product Quality Issue, Haemorrhagic Stroke
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Heparin
Dosage: 2500 units once intra-arterially unsure which vial
Indication: Angioplasty
Start date: 2012-07-18
Heparin
Dosage: 2500 units once intra-arterially unsure which vial
Indication: Renal Artery Stent Placement
Start date: 2012-07-18
Heparin
Dosage: 2500 units once intra-arterially unsure which vial
Indication: Thrombosis Prophylaxis
Possible Heparin side effects in 77 year old male
Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-07
Patient: 77 year old male
Reactions: Heparin-Induced Thrombocytopenia, Bacterial Sepsis, Post Procedural Haemorrhage, Epistaxis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Heparin
Other drugs received by patient: Vasopressin and Analogues; Verapamil; Epinephrine
Possible Heparin side effects in 57 year old female
Reported by a physician from United States on 2012-08-06
Patient: 57 year old female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Alcohol
Dosage: unk
Ambien
Dosage: unk
Caffeine Citrate
Dosage: unk
Ceclor
Dosage: unk
Ceftin
Dosage: unk
Ciprofloxacin HCL
Dosage: unk
Cleocin Hydrochloride
Dosage: unk
Compazine
Dosage: unk
Duricef
Dosage: unk
Epinephrine
Dosage: unk
Gadolinium
Dosage: unk
Heparin
Dosage: unk
Indocin
Dosage: unk
Iodine
Dosage: unk
Monistat
Dosage: unk
Mycelex
Dosage: unk
Nizoral
Dosage: unk
Oxymetazoline HCL
Dosage: unk
Relafen
Dosage: unk
Possible Heparin side effects in 67 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-03
Patient: 67 year old male
Reactions: Haemorrhagic Transformation Stroke, Intraventricular Haemorrhage, Unresponsive To Stimuli, Aphasia, Hemiparesis, Cerebral Haemorrhage
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Acetylsalicylic Acid SRT
Indication: Antiplatelet Therapy
Alteplase
Dosage: 90 mg, unk
Clopidogrel
Indication: Antiplatelet Therapy
Heparin
Tirofibran
Tirofibran
Other drugs received by patient: Lisinopril; Insulin; Gemfibrozil
Possible Heparin side effects in
Reported by a physician from Canada on 2012-08-03
Patient:
Reactions: Electrocardiogram ST Segment Abnormal, Drug Ineffective, Chest Pain, Myocardial Ischaemia, Electrocardiogram T Wave Abnormal, Condition Aggravated, Electrocardiogram ST Segment Elevation
Drug(s) suspected as cause:
Aspirin
Indication: Product Used FOR Unknown Indication
Heparin
Dosage: unk
Indication: Acute Myocardial Infarction
Tenecteplase
Dosage: unk
Indication: Acute Myocardial Infarction
Possible Heparin side effects in 67 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-03
Patient: 67 year old male
Reactions: Intraventricular Haemorrhage, Haemorrhagic Transformation Stroke, Unresponsive To Stimuli, Aphasia, Hemiparesis, Cerebral Haemorrhage
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Acetylsalicylic Acid
Indication: Antiplatelet Therapy
Alteplase
Dosage: 90 mg, unk
Clopidogrel
Indication: Antiplatelet Therapy
Heparin
Tirofibran
Tirofibran
Other drugs received by patient: Lisinopril; Gemfibrozil; Insulin
Possible Heparin side effects in 38 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02
Patient: 38 year old female
Reactions: Spinal Cord Infarction, Nausea, Loss of Consciousness, Hypoxic-Ischaemic Encephalopathy, Cardio-Respiratory Arrest, Neck Pain, Vertebral Artery Dissection, Subarachnoid Haemorrhage, Ventricular Tachycardia, Asthenia, Sinus Tachycardia
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Heparin
Other drugs received by patient: Cyanocobalamin; Lidocaine
Possible Heparin side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02
Patient:
Reactions: Caesarean Section, Maternal Exposure During Pregnancy
Drug(s) suspected as cause:
Aspirin
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Clopidogrel
Dosage: maternal dose
Ferrous Sulfate TAB
Dosage: maternal dose
Heparin
Hydralazine HCL
Dosage: maternal dose
Hydralazine HCL
Dosage: maternal dose
Metoprolol Tartrate
Dosage: maternal dose
Morphine Sulfate
Vitamins (Unspecified)
Zocor
Dosage: maternal dose
[composition Unspecified]
Possible Heparin side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02
Patient:
Reactions: Maternal Drugs Affecting Foetus, Premature Baby, Foetal Exposure During Pregnancy
Drug(s) suspected as cause:
Aspirin
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Carvedilol
Dosage: maternal dose
Clopidogrel
Dosage: maternal dose
Ferrous Sulfate TAB
Dosage: maternal dose
Heparin
Hydralazine HCL
Dosage: maternal dose
Hydralazine HCL
Dosage: maternal dose
Metoprolol Tartrate
Dosage: maternal dose
Morphine Sulfate
Vitamins (Unspecified)
Zocor
Dosage: maternal dose
[composition Unspecified]
Possible Heparin side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-01
Patient: male
Reactions: Neurological Decompensation, Headache, Hemiparesis, Cerebral Ventricle Dilatation, Subdural Haemorrhage, Cerebral Haemorrhage, Cerebral Infarction, Intracranial Pressure Increased, Intracranial Venous Sinus Thrombosis
Drug(s) suspected as cause:
Alteplase
Indication: Superior Sagittal Sinus Thrombosis
Heparin
Indication: Superior Sagittal Sinus Thrombosis
Possible Heparin side effects in 53 year old male
Reported by a pharmacist from United States on 2012-07-31
Patient: 53 year old male, weighing 102.0 kg (224.4 pounds)
Reactions: Product Measured Potency Issue, Coagulation Time Shortened
Drug(s) suspected as cause:
Heparin
Possible Heparin side effects in 60 year old female
Reported by a physician from Poland on 2012-07-31
Patient: 60 year old female
Reactions: Thrombosis
Drug(s) suspected as cause:
Boniva
Dosage: dose reported as 3mg/3ml
Indication: Osteoporosis Postmenopausal
Start date: 2012-01-01
Heparin
Indication: Thrombosis
Other drugs received by patient: Enoxaparin Sodium; Vitamin D
Possible Heparin side effects in 83 year old male
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: 83 year old male, weighing 78.0 kg (171.6 pounds)
Reactions: Pneumonia, Renal Failure Acute
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Amlodipine
Dosage: unk
End date: 2010-12-16
Heparin
Dosage: 0.02 mg/kg bolus
Start date: 2010-12-16
End date: 2010-12-16
Heparin
Dosage: 0.01 mg/kg, hr
Start date: 2010-12-16
End date: 2010-12-17
Heparin
Dosage: 66 iu/kg, bolus
Indication: Percutaneous Coronary Intervention
Start date: 2010-12-16
End date: 2010-12-16
Iopromide
Dosage: 222 ml, once
Indication: Angiogram
Start date: 2010-12-16
End date: 2010-12-16
Other drugs received by patient: Aspirin; Tirofiban; Bisoprolol Fumarate; Acetylcysteine; Aspirin; Clopidogrel; Valsartan; Aspirin; Clopidogrel; Clopidogrel; Heparin; Sinvastatina Mepha; Pantoprazole
Possible Heparin side effects in
Reported by a individual with unspecified qualification from Canada on 2012-07-30
Patient:
Reactions: Haemorrhage, Myocardial Ischaemia, Haemorrhage Intracranial, Catheter Site Haemorrhage, Cardiogenic Shock, Death, Cardiac Failure, Myocardial Infarction
Adverse event resulted in: death
Drug(s) suspected as cause:
Aspirin
Dosage: unk
Indication: Acute Myocardial Infarction
Clopidogrel
Dosage: 300 mg, unk
Indication: Acute Myocardial Infarction
Clopidogrel
Dosage: 75 mg, unk
GP IIB / Iiia Inhibitor (Study Drug)
Dosage: unk
Indication: Acute Myocardial Infarction
Heparin
Dosage: unk
Indication: Acute Myocardial Infarction
Tnkase
Dosage: unk
Indication: Acute Myocardial Infarction
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