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Janumet (Sitagliptin / Metformin) - Renal Failure - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Renal Failure (18)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Janumet (Sitagliptin / Metformin) where reactions include renal failure. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Janumet side effects in

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-31

Patient:

Reactions: Rhabdomyolysis, Anaemia, Hepatic Failure, Lactic Acidosis, Factor V Deficiency, Multi-Organ Failure, Renal Failure, Escherichia Test Positive, Thrombocytopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Copegus
    Administration route: Oral

Janumet
    Administration route: Oral

Pegasys

Telaprevir
    Administration route: Oral



Possible Janumet side effects in 81 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-06-29

Patient: 81 year old male, weighing 88.0 kg (193.6 pounds)

Reactions: Conjunctivitis, Myocardial Ischaemia, Aortic Aneurysm, Enthesopathy, Rectal Haemorrhage, Shock Haemorrhagic, Eczema, Hyperuricaemia, Microcytic Anaemia, Acute Myocardial Infarction, Gastrointestinal Angiodysplasia, Right Ventricular Failure, Pneumonia, Metabolic Acidosis, Gastritis Haemorrhagic, Diverticulum Intestinal, Cholelithiasis, Osteoarthritis, Hyperlipidaemia, Renal Failure, Respiratory Failure, Dehydration, Gastroenteritis, Peripheral Arterial Occlusive Disease, Systemic Inflammatory Response Syndrome, Hypertension, Hyperthyroidism

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Janumet



Possible Janumet side effects in 81 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-06-28

Patient: 81 year old male, weighing 88.0 kg (193.6 pounds)

Reactions: Myocardial Ischaemia, Aortic Aneurysm, Enthesopathy, Rectal Haemorrhage, Shock Haemorrhagic, Conjunctivitis, Eczema, Hyperuricaemia, Microcytic Anaemia, Acute Myocardial Infarction, Gastrointestinal Angiodysplasia, Right Ventricular Failure, Metabolic Acidosis, Pneumonia, Gastritis Haemorrhagic, Diverticulum Intestinal, Hyperlipidaemia, Osteoarthritis, Cholelithiasis, Renal Failure, Respiratory Failure, Dehydration, Gastroenteritis, Systemic Inflammatory Response Syndrome, Peripheral Arterial Occlusive Disease, Hyperthyroidism, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Janumet



Possible Janumet side effects in male

Reported by a physician from France on 2012-05-01

Patient: male, weighing 49.0 kg (107.8 pounds)

Reactions: Rhabdomyolysis, Anaemia, Hepatic Failure, Lactic Acidosis, Factor V Deficiency, Multi-Organ Failure, Renal Failure, Escherichia Test Positive, Thrombocytopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Incivo
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-01-24
    End date: 2012-04-10

Pegasys
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-01-24
    End date: 2012-04-10

Copegus
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-01-24

Copegus

Janumet
    Indication: Product Used FOR Unknown Indication
    End date: 2012-04-10



Possible Janumet side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-19

Patient: female

Reactions: Renal Failure

Drug(s) suspected as cause:
Janumet



Possible Janumet side effects in 71 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-09

Patient: 71 year old male, weighing 100.0 kg (220.0 pounds)

Reactions: Renal Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hydrochlorothiazide and Nebivolol Hydrochloride
    Administration route: Oral
    End date: 2012-02-01

Janumet
    Administration route: Oral
    Indication: Insulin-Requiring Type 2 Diabetes Mellitus
    End date: 2012-02-01

Other drugs received by patient: Domperidone; Amlodipine Besylate; Aspirin Lysine; Insulin Glargine; Telmisartan; Rabeprazole Sodium; Atorvastatin Calcium



Possible Janumet side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-09

Patient: 47 year old male, weighing 90.0 kg (198.0 pounds)

Reactions: Renal Failure, Pancreatitis Necrotising, Lactic Acidosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Ramipril
    Administration route: Oral
    Start date: 2011-09-01
    End date: 2011-12-25

Irbesartan + Hydrochlorothiazide
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-09-01
    End date: 2011-12-25

Janumet
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-01-01
    End date: 2011-12-25

Other drugs received by patient: Insulin; Aspirin and Clopidogrel Bisulfate; Bisoprolol Fumarate



Possible Janumet side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-05

Patient: 47 year old male

Reactions: Renal Failure, Oedematous Pancreatitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Ramipril
    Dosage: 50 mg once daily
    Administration route: Oral
    Start date: 2011-09-01
    End date: 2011-12-25

Irbesartan + Hydrochlorothiazide
    Dosage: 300 mg/12.5 mg at 1 u once daily
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-09-01
    End date: 2011-12-25

Janumet
    Dosage: 50 mg/1000 mg at 1 u twice daily
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-01-01
    End date: 2011-12-25

Other drugs received by patient: Insulin; Bisoprolol Fumarate; Clopidogrel Bisulfate and Aspirin



Possible Janumet side effects in 47 year old male

Reported by a consumer/non-health professional from France on 2012-04-04

Patient: 47 year old male

Reactions: Renal Failure, Oedematous Pancreatitis, Lactic Acidosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Irbesartan and Hydrochlorothiazide
    Dosage: 1df:300mg/12.5mg
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-09-01
    End date: 2011-12-25

Janumet
    Dosage: 1df:50mg/1000mg
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-01-01
    End date: 2011-12-25

Ramipril
    Administration route: Oral
    Start date: 2011-09-01
    End date: 2011-12-25

Other drugs received by patient: Bisoprolol Fumarate; Insulin; Clopidogrel Bisulfate and Aspirin



Possible Janumet side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-04

Patient: 47 year old male, weighing 90.0 kg (198.0 pounds)

Reactions: Multi-Organ Failure, Renal Failure, Pancreatitis Necrotising, Lactic Acidosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Hydrochlorothiazide
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-09-01
    End date: 2011-12-25

Janumet
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-01-01
    End date: 2011-12-25

Ramipril
    Administration route: Oral
    Start date: 2011-09-01
    End date: 2011-12-25

Other drugs received by patient: Aspirin and Clopidogrel Bisulfate; Insulin; Bisoprolol Fumarate



Possible Janumet side effects in 71 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-27

Patient: 71 year old male

Reactions: Renal Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Janumet
    Administration route: Oral
    Indication: Insulin-Requiring Type 2 Diabetes Mellitus
    End date: 2012-02-01

Hydrochlorothiazide and Nebivolol Hydrochloride
    Administration route: Oral
    End date: 2012-02-01

Other drugs received by patient: Telmisartan; Atorvastatin Calcium; Aspirin Lysine; Rabeprazole Sodium; Insulin Glargine; Amlodipine Besylate; Domperidone



Possible Janumet side effects in 64 year old male

Reported by a physician from France on 2012-01-20

Patient: 64 year old male, weighing 106.0 kg (233.2 pounds)

Reactions: Weight Decreased, Renal Failure, Drug Ineffective, Incorrect Dose Administered, Encephalitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Janumet
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-03-15
    End date: 2011-01-11

Janumet
    Administration route: Oral
    Start date: 2011-01-12
    End date: 2011-08-30



Possible Janumet side effects in 55 year old female

Reported by a physician from France on 2011-12-27

Patient: 55 year old female

Reactions: Renal Failure

Drug(s) suspected as cause:
Janumet

Other drugs received by patient: Metformin; Repaglinide



Possible Janumet side effects in 68 year old female

Reported by a physician from Germany on 2011-12-21

Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Abdominal Pain Lower, Weight Decreased, Uterine Polyp, Diverticulum Intestinal, Anaemia Vitamin B12 Deficiency, Renal Failure, Fatigue, Adverse Event, Dizziness, Depression, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Janumet

Other drugs received by patient: Tramadol Hydrochloride; Allopurinol; Ibuprofen; Simvastatin; Pantoprazole; Imipramine Hydrochloride; Aspirin



Possible Janumet side effects in 70 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-12

Patient: 70 year old male, weighing 76.0 kg (167.2 pounds)

Reactions: Portal Vein Thrombosis, Hyperglycaemia, Hypotension, Cytolytic Hepatitis, Tachycardia, Pancreatic Cyst, Hepatic Failure, Cholestasis, Tumour Compression, Lactic Acidosis, Hepatitis, Haemodynamic Instability, Renal Failure, Bile Duct Stenosis, Biliary Dilatation, Abdominal Sepsis, Gastric Fistula

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Januvia
    Administration route: Oral
    Indication: Pancreatogenous Diabetes
    Start date: 2011-09-19
    End date: 2011-10-07

Janumet
    Administration route: Oral
    Indication: Pancreatogenous Diabetes
    Start date: 2011-06-23
    End date: 2011-09-19

Other drugs received by patient: Aspirin and Pravastatin Sodium; SAW Palmetto; Irbesartan; Pancreatin; Repaglinide



Possible Janumet side effects in 68 year old female

Reported by a consumer/non-health professional from Germany on 2011-11-29

Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Abdominal Pain Lower, Weight Decreased, Uterine Polyp, Diverticulum Intestinal, Anaemia Vitamin B12 Deficiency, Fatigue, Renal Failure, Adverse Event, Dizziness, Depression, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Janumet

Other drugs received by patient: Pantoprazole; Ibuprofen; Tramadol Hydrochloride; Allopurinol; Imipramine Hydrochloride; Simvastatin; Aspirin



Possible Janumet side effects in 68 year old female

Reported by a consumer/non-health professional from Germany on 2011-11-23

Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Weight Decreased, Abdominal Pain Lower, Uterine Polyp, Diverticulum Intestinal, Anaemia Vitamin B12 Deficiency, Fatigue, Renal Failure, Dizziness, Adverse Event, Depression, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Janumet

Other drugs received by patient: Ibuprofen; Simvastatin; Tramadol Hydrochloride; Aspirin; Pantoprazole; Imipramine Hydrochloride; Allopurinol



Possible Janumet side effects in 64 year old male

Reported by a physician from France on 2011-10-17

Patient: 64 year old male, weighing 106.0 kg (233.2 pounds)

Reactions: Weight Decreased, Renal Failure, Drug Ineffective, Incorrect Dose Administered, Encephalitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Janumet
    Administration route: Oral
    Start date: 2011-01-12
    End date: 2011-09-15

Janumet
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-03-15
    End date: 2011-01-11

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