This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Kadian (Morphine) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (87)
Death (68)
Life Threatening Events (4)
Disability (2)
Reports by Reaction Type
Toxicity To Various Agents (43),
Unresponsive To Stimuli (40),
Completed Suicide (14),
Hypotension (14),
Pulmonary Oedema (11),
Accidental Death (10),
Intentional Drug Misuse (10),
Drug Abuse (8),
Cardio-Respiratory Arrest (8),
Brain Oedema (8),
Drug Screen Positive (7),
Apnoea (7)
Below are a few examples of reports where side effects / adverse reactions may be related to Kadian (Morphine). For a complete list or a specific selection of reports, please use the links above.
Possible Kadian side effects in 78 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 78 year old female
Reactions: Drug Ineffective, Incorrect Dose Administered, Pain, Fall, Insomnia, Heart Rate Irregular, Spinal Column Injury, Feeling Abnormal, Intervertebral Disc Injury
Drug(s) suspected as cause:
Excedrin Extra Strength Caplets
Dosage: 2 df, unk
Administration route: Oral
Start date: 1965-01-01
Excedrin Extra Strength Caplets
Dosage: 3 df, prn
Administration route: Oral
Indication: Headache
Start date: 1965-01-01
Kadian
Dosage: 100 mg, unk
Indication: Spinal Column Injury
Other drugs received by patient: Aspirin
Possible Kadian side effects in 78 year old female
Reported by a consumer/non-health professional from United States on 2012-08-16
Patient: 78 year old female
Reactions: Drug Ineffective, Incorrect Dose Administered, Pain, Fall, Insomnia, Heart Rate Irregular, Spinal Column Injury, Feeling Abnormal, Intervertebral Disc Injury
Drug(s) suspected as cause:
Excedrin Extra Strength Caplets
Dosage: 2 df, unk
Administration route: Oral
Start date: 1965-01-01
Excedrin Extra Strength Caplets
Dosage: 3 df, prn
Administration route: Oral
Indication: Headache
Start date: 1965-01-01
Kadian
Dosage: 100 mg, unk
Indication: Spinal Column Injury
Other drugs received by patient: Aspirin
Possible Kadian side effects in 24 year old male
Reported by a physician from United States on 2012-08-09
Patient: 24 year old male, weighing 97.5 kg (214.6 pounds)
Reactions: Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Hydrocodone Bitartrate
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Fluoxetine
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Kadian
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Oxycodone HCL
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Possible Kadian side effects in 25 year old female
Reported by a physician from United States on 2012-08-09
Patient: 25 year old female
Reactions: Abdominal Pain, Agitation, Pain, Acidosis, Treatment Noncompliance, Drug Abuse, Intentional Self-Injury, Hepatomegaly, Blood Fibrinogen Decreased, Dialysis, Hepatorenal Syndrome, Pleural Effusion, Gallbladder Disorder, Electrolyte Imbalance, Blood Glucose Increased, Vomiting, International Normalised Ratio Increased, Laceration, Blood Potassium Increased, Blood Fibrinogen Increased, Alcohol Use, Dysarthria, Renal Failure, Depressed Level of Consciousness, Suicide Attempt
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Acetaminophen and Diphenhydramine Hydrochloride
Cocaine
Diazepam
Ethanol
Kadian
Salicylates - Opiods
Other drugs received by patient: Piperacillin and Tazobactam; Trimethoprim + Sulfamethoxazole; Ampicillin
Possible Kadian side effects in 29 year old male
Reported by a physician from United States on 2012-08-09
Patient: 29 year old male
Reactions: Cardio-Respiratory Arrest, Unresponsive To Stimuli, Left Ventricular Hypertrophy, Blood PH Decreased, Pupil Fixed, Toxicity To Various Agents, Cardiomegaly
Adverse event resulted in: death
Drug(s) suspected as cause:
Ethanol
Dosage: parn
Kadian
Dosage: parn
Possible Kadian side effects in 15 year old male
Reported by a physician from United States on 2012-08-09
Patient: 15 year old male
Reactions: Unresponsive To Stimuli, Hypotension, Clonus, Encephalopathy, Abnormal Behaviour, Myoclonus, Cardio-Respiratory Arrest, Brain Oedema
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Kadian
Possible Kadian side effects in 19 year old male
Reported by a physician from United States on 2012-08-09
Patient: 19 year old male
Reactions: Unresponsive To Stimuli, Blood Potassium Increased, Toxicity To Various Agents, Foaming AT Mouth, Pulse Absent, Pupil Fixed, Ventricular Fibrillation, Apnoea, Pulseless Electrical Activity
Adverse event resulted in: death
Drug(s) suspected as cause:
Codeine Sulfate
Indication: Intentional Drug Misuse
Heroin
Indication: Intentional Drug Misuse
Kadian
Indication: Intentional Drug Misuse
Possible Kadian side effects in 60 year old female
Reported by a physician from United States on 2012-08-09
Patient: 60 year old female, weighing 62.6 kg (137.7 pounds)
Reactions: Respiratory Rate Increased, Tongue Discolouration, Unresponsive To Stimuli, General Physical Health Deterioration, Oesophageal Perforation, Muscle Necrosis, Gastric Perforation, Dialysis, Aspartate Aminotransferase Increased, Completed Suicide, Platelet Count Decreased, Pneumothorax, Gastrointestinal Sounds Abnormal, Blood Pressure Decreased, Anuria, Blood Glucose Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Diazepam
Indication: Product Used FOR Unknown Indication
Ethanol
Dosage: po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydrochloric Acid
Dosage: po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydromorphone Hydrochloride
Indication: Product Used FOR Unknown Indication
Kadian
Indication: Product Used FOR Unknown Indication
Lorazepam
Indication: Product Used FOR Unknown Indication
Nordiazepam
Indication: Product Used FOR Unknown Indication
Possible Kadian side effects in 57 year old female
Reported by a physician from United States on 2012-08-09
Patient: 57 year old female, weighing 68.9 kg (151.7 pounds)
Reactions: Unresponsive To Stimuli, Accidental Death, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Diazepam
Kadian
Dosage: po
Administration route: Oral
Oxycodone HCL
Dosage: po
Administration route: Oral
Possible Kadian side effects in 36 year old male
Reported by a physician from United States on 2012-08-09
Patient: 36 year old male, weighing 76.7 kg (168.6 pounds)
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Hydrocodone
Alprazolam
Diphenhydramine Hydrochloride
Ethanol
Kadian
Possible Kadian side effects in 33 year old male
Reported by a physician from United States on 2012-08-09
Patient: 33 year old male, weighing 105.2 kg (231.5 pounds)
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents, Drug Abuse
Adverse event resulted in: death
Drug(s) suspected as cause:
Citalopram Hydrobromide
Diphenhydramine Hydrochloride
Kadian
Trazodone Hydrochloride
Possible Kadian side effects in 38 year old male
Reported by a physician from United States on 2012-08-09
Patient: 38 year old male
Reactions: Mydriasis, Completed Suicide, Unresponsive To Stimuli, Multiple Drug Overdose, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Hydrocodone Bitartrate
Cocaine
Diazepam
Ethanol
Kadian
Tramadol HCL
Possible Kadian side effects in 16 year old female
Reported by a physician from United States on 2012-08-09
Patient: 16 year old female
Reactions: Blood Pressure Systolic Decreased, Cardio-Respiratory Arrest, Cerebral Infarction, Heart Rate Increased, Unresponsive To Stimuli, Brain Oedema, Ventricular Fibrillation, Blood Glucose Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Acetaminophen and Codeine Phosphate
Dosage: po
Administration route: Oral
Amitriptyline Hydrochloride
Ciprofloxacin
Dosage: po
Administration route: Oral
Gabapentin
Dosage: po
Administration route: Oral
Hydrocodone
Kadian
Dosage: po
Administration route: Oral
Indication: Completed Suicide
Kadian
Dosage: po
Administration route: Oral
Indication: Intentional Overdose
Metoprolol Tartrate
Dosage: po
Administration route: Oral
Oxycodone HCL
Phenazopyridine HCL TAB
Dosage: po
Administration route: Oral
Phenazopyridine HCL TAB
Dosage: po
Administration route: Oral
Tricyclic Antidepressant
Dosage: po
Administration route: Oral
Other drugs received by patient: Contraceptive Implantable Device
Possible Kadian side effects in 27 year old male
Reported by a physician from United States on 2012-08-09
Patient: 27 year old male, weighing 103.0 kg (226.6 pounds)
Reactions: Pulmonary Alveolar Haemorrhage, Unresponsive To Stimuli, Accidental Death, Toxicity To Various Agents, Pulmonary Congestion, Hepatic Congestion, Brain Oedema, Pulmonary Oedema, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Citalopram Hydrobromide
Kadian
Methamphetamine Hydrochloride
Possible Kadian side effects in 28 year old male
Reported by a physician from United States on 2012-08-09
Patient: 28 year old male, weighing 97.0 kg (213.4 pounds)
Reactions: Excoriation, Pulmonary Congestion, Unresponsive To Stimuli, Pulmonary Oedema, Intentional Drug Misuse, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Chlordiazepoxide
Diazepam
Ethanol
Kadian
Tramadol HCL
Possible Kadian side effects in 51 year old female
Reported by a physician from United States on 2012-08-09
Patient: 51 year old female
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents, Nephrosclerosis, Pallor, Hepatitis, Cardiomegaly, Completed Suicide, Ventricular Tachycardia, Brain Oedema, Carditis, Pulmonary Oedema, Pulse Absent, Pupil Fixed, Cold Sweat, Blood Pressure Decreased
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Indication: Completed Suicide
Fluoxetine
Indication: Completed Suicide
Hydromorphone HCL
Indication: Completed Suicide
Kadian
Indication: Completed Suicide
Promethazine HCL
Indication: Completed Suicide
Other drugs received by patient: Lisinopril; Rifampin; Dicloxacillin; Ciprofloxacin; Montelukast; Clindamycin
Possible Kadian side effects in 50 year old male
Reported by a physician from United States on 2012-08-09
Patient: 50 year old male
Reactions: Unresponsive To Stimuli, Accidental Death, Intentional Drug Misuse, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Diazepam
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Kadian
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Methamphetamine Hydrochloride
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Oxycodone HCL
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Possible Kadian side effects in 4 year old female
Reported by a physician from United States on 2012-08-09
Patient: 4 year old female
Reactions: Brain Death, Respiratory Rate Decreased, Mydriasis, Brain Herniation, Breath Sounds Abnormal, Hypotension, Brain Oedema, Convulsion
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Alprazolam
Dosage: po
Administration route: Oral
Kadian
Dosage: po
Administration route: Oral
Oxycodone and Acetaminophen
Dosage: po
Administration route: Oral
Possible Kadian side effects in 55 year old female
Reported by a physician from United States on 2012-08-09
Patient: 55 year old female
Reactions: Unresponsive To Stimuli, Completed Suicide, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Hydrocodone Bitartrate
Fluoxetine
Dosage: po
Administration route: Oral
Kadian
Dosage: po
Administration route: Oral
Quetiapine
Possible Kadian side effects in 20 year old male
Reported by a physician from United States on 2012-08-09
Patient: 20 year old male
Reactions: Brain Death, Coma, Toxicity To Various Agents, Intentional Drug Misuse, Drug Abuse, Loss of Consciousness, Overdose, Respiratory Arrest, Brain Oedema
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Heroin
Dosage: parn
Indication: Drug Abuse
Kadian
Dosage: parn
Indication: Intentional Drug Misuse
Lorazepam
Dosage: parn
Indication: Drug Abuse
Oxycodone HCL
Dosage: parn
Indication: Intentional Drug Misuse
Possible Kadian side effects in 32 year old female
Reported by a physician from United States on 2012-08-09
Patient: 32 year old female
Reactions: Cardio-Respiratory Arrest, Hypoxic-Ischaemic Encephalopathy, Hepatotoxicity, Alanine Aminotransferase Increased, Accidental Overdose, Blood Sodium Decreased, Blood Glucose Increased, White Blood Cell Count Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Kadian
Possible Kadian side effects in 19 year old male
Reported by a physician from United States on 2012-08-09
Patient: 19 year old male
Reactions: Cardio-Respiratory Arrest, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: po
Administration route: Oral
Kadian
Dosage: po
Administration route: Oral
Oxycodone HCL
Dosage: po
Administration route: Oral
Possible Kadian side effects in 17 year old male
Reported by a physician from United States on 2012-08-09
Patient: 17 year old male
Reactions: Brain Herniation, Alanine Aminotransferase Increased, Unresponsive To Stimuli, Hypotension, Drug Abuse, Haemodialysis, Cardiomegaly, Loss of Consciousness, Cerebellar Infarction, Renal Failure
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Clonazepam
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Kadian
Indication: Sedation
Oxycodone and Acetaminophen
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Zolpidem Tartrate
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Possible Kadian side effects in 90 year old female
Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-08-09
Patient: 90 year old female
Reactions: Skin Exfoliation, Excoriation, Rash, Skin Reaction, Blister
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Clonazepam
Dosage: 125 ug;qd;po
Administration route: Oral
Indication: Analgesic Therapy
Start date: 2012-06-30
End date: 2012-07-09
Kadian
Dosage: 5 mg;q2h;po
Administration route: Oral
Indication: Analgesic Therapy
Metoclopramide Hydrochloride
Dosage: 10 mg;qd;po
Administration route: Oral
Indication: Nausea
Start date: 2012-06-19
End date: 2012-07-10
Ondansetron
Dosage: 4 po;bid;po
Administration route: Oral
Indication: Nausea
Start date: 2012-06-28
Oxycodone HCL
Dosage: 5 mg;prn;po
Administration route: Oral
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-07-05
Possible Kadian side effects in 26 year old male
Reported by a physician from United States on 2012-08-09
Patient: 26 year old male, weighing 73.0 kg (160.6 pounds)
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents, Intentional Drug Misuse, Drug Abuse
Adverse event resulted in: death
Drug(s) suspected as cause:
Codeine Sulfate
Dosage: unk
Ethanol
Dosage: unk
Heroin
Dosage: unk
Kadian
Dosage: unk
Oxycodone HCL
Dosage: unk
Possible Kadian side effects in 28 year old male
Reported by a physician from United States on 2012-08-09
Patient: 28 year old male
Reactions: Unresponsive To Stimuli, Blood Potassium Increased, Intentional Drug Misuse, Pericardial Effusion, Multi-Organ Failure, Hypoxic-Ischaemic Encephalopathy, Hepatic Congestion, Apnoea, Cardiac Arrest, Blood Glucose Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Kadian
Other drugs received by patient: Methadone HCL
Possible Kadian side effects in 50 year old male
Reported by a physician from United States on 2012-08-09
Patient: 50 year old male, weighing 114.8 kg (252.5 pounds)
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents, Drug Abuse
Adverse event resulted in: death
Drug(s) suspected as cause:
Kadian
Possible Kadian side effects in 29 year old male
Reported by a physician from United States on 2012-08-09
Patient: 29 year old male
Reactions: Electrocardiogram ST Segment Abnormal, Vomiting, Unresponsive To Stimuli, Hypotension, Bundle Branch Block Right, Toxicity To Various Agents, Resuscitation, Loss of Consciousness, Pulmonary Congestion, Pulmonary Oedema, Pulse Absent, Opiates Positive, Apnoea
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Clonazepam
Dosage: iv
Indication: Intentional Drug Misuse
Heroin
Dosage: iv
Indication: Intentional Drug Misuse
Kadian
Dosage: iv
Indication: Intentional Drug Misuse
Pregabalin
Dosage: iv
Indication: Intentional Drug Misuse
Possible Kadian side effects in 14 year old male
Reported by a physician from United States on 2012-08-09
Patient: 14 year old male, weighing 113.4 kg (249.5 pounds)
Reactions: Unresponsive To Stimuli, Snoring, Headache, Pyrexia, Ulcer, Pulmonary Oedema, Apnoea, Pain in JAW, Hepatosplenomegaly
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Codeine Phosphate
Dosage: po
Administration route: Oral
Indication: Abscess
Aripiprazole
Dosage: po
Administration route: Oral
Clonidine HCL
Dosage: po
Administration route: Oral
Codeine Sulfate
Dosage: po
Administration route: Oral
Diphenhydramine Hydrochloride
Dosage: po
Administration route: Oral
Kadian
Dosage: po
Administration route: Oral
Lisdexamfetamine Dimesylate
Dosage: po
Administration route: Oral
Meloxicam
Dosage: po
Administration route: Oral
Penicillin G Potassium
Dosage: po
Administration route: Oral
Indication: Wisdom Teeth Removal
Quetiapine
Dosage: po
Administration route: Oral
Sertraline Hydrochloride
Dosage: po
Administration route: Oral
Valproic Acid
Dosage: po
Administration route: Oral
Possible Kadian side effects in 55 year old male
Reported by a physician from United States on 2012-08-09
Patient: 55 year old male, weighing 72.0 kg (158.4 pounds)
Reactions: Unresponsive To Stimuli, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen and Hydrocodone
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Amitriptyline Hydrochloride
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Ethanol
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Kadian
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Phenobarbital TAB
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
Skeletal Muscle Relaxant
Dosage: po
Administration route: Oral
Indication: Intentional Drug Misuse
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