This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Macugen (Pegaptanib) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (35)
Death (6)
Life Threatening Events (2)
Disability (2)
Reports by Reaction Type
Visual Acuity Reduced (6),
Cerebral Infarction (4),
Glaucoma (3),
Intraocular Pressure Increased (3),
Fall (3),
Retinal Haemorrhage (3),
Hypertension (3),
Drug Ineffective (2),
Upper Limb Fracture (2),
Aphasia (2),
Gastritis (2),
Death (2)
Below are a few examples of reports where side effects / adverse reactions may be related to Macugen (Pegaptanib). For a complete list or a specific selection of reports, please use the links above.
Possible Macugen side effects in male
Reported by a physician from Japan on 2012-08-09
Patient: male
Reactions: Cerebral Infarction
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Levofloxacin
Possible Macugen side effects in female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-27
Patient: female, weighing 73.5 kg (161.8 pounds)
Reactions: Glaucoma, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Micardis; Nerisona; Coniel; Xalcom; Novorapid; Kalimate; Hirudoid / 00723701 /; Azopt; Crestor; Famotidine
Possible Macugen side effects in male
Reported by a physician from Japan on 2012-07-19
Patient: male
Reactions: Cerebral Infarction
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Levofloxacin
Possible Macugen side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-27
Patient: female, weighing 74.8 kg (164.7 pounds)
Reactions: Off Label Use, Renal Transplant, Aphasia, Blindness Unilateral, Cerebrovascular Accident, Type 1 Diabetes Mellitus, Hypertension
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Macugen
Dosage: (df intraocular) ; (df intraocular) ; (df intraocular)
Indication: Diabetic Retinal Oedema
Start date: 2008-09-05
End date: 2008-09-05
Macugen
Dosage: (df intraocular) ; (df intraocular) ; (df intraocular)
Indication: Diabetic Retinal Oedema
Start date: 2009-06-22
End date: 2009-06-22
Macugen
Dosage: (df intraocular) ; (df intraocular) ; (df intraocular)
Indication: Diabetic Retinal Oedema
Start date: 2009-03-30
End date: 2009-03-30
Other drugs received by patient: Insulin
Possible Macugen side effects in
Reported by a consumer/non-health professional from United States on 2012-06-19
Patient:
Reactions: Off Label Use, Aphasia, Cerebrovascular Accident
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Dosage: df, df, df
Indication: Diabetic Retinal Oedema
Start date: 2009-06-22
End date: 2009-06-22
Macugen
Dosage: df, df, df
Indication: Diabetic Retinal Oedema
Start date: 2008-09-05
End date: 2008-09-05
Macugen
Dosage: df, df, df
Indication: Diabetic Retinal Oedema
Start date: 2009-03-30
End date: 2009-03-30
Possible Macugen side effects in 73 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-22
Patient: 73 year old female
Reactions: Procedural Pain, Eye Pain
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 60 year old female
Reported by a physician from Japan on 2012-03-26
Patient: 60 year old female, weighing 73.5 kg (161.7 pounds)
Reactions: Dyslipidaemia, Glaucoma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Sodium Polystyrene Sulfonate; Coniel (Benidipine Hydrochloride); Novolog; Xalacom (Latanoprost, Timolol Maleate); Hirudoid (Heparinoid); Micardis; Crestor; Azopt; Nerisone; Famotidine
Possible Macugen side effects in 60 year old female
Reported by a physician from Japan on 2012-03-21
Patient: 60 year old female, weighing 73.5 kg (161.7 pounds)
Reactions: Glaucoma, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Famotidine; Nerisone; Xalacom (Latanoprost, Timolol Maleate); Azopt; Hirudoid (Heparinoid); Novolog; Coniel (Benidipine Hydrochloride); Crestor; Sodium Polystyrene Sulfonate; Micardis
Possible Macugen side effects in 76 year old female
Reported by a physician from Italy on 2012-03-21
Patient: 76 year old female
Reactions: Upper Limb Fracture, Fall
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Combisartan (Hydrochlorothiazide, Valsartan); Simvastatin; Aspirin; Methylprednisolone; Pantoprazole
Possible Macugen side effects in 67 year old male
Reported by a physician from Germany on 2012-03-19
Patient: 67 year old male
Reactions: Epididymitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Roekan (Ginkgo Biloba Extract); Gabapentin; Opipramol Hydrochloride (Opipramol Hydrochloride)
Possible Macugen side effects in 72 year old male
Reported by a physician from Japan on 2012-03-19
Patient: 72 year old male, weighing 59.0 kg (129.8 pounds)
Reactions: Intraocular Pressure Increased, Gastritis
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Rinderon A (Betamethasone Sodium Phosphate, Neomycin Sulfate); Mucosta (Rebamipide); Methycobal (Mecobalamin); Bronuck (Bromfenac Sodium); Aspara K (Aspartate Potassium); Lomefloxacin Hydrochloride (Lomefloxacin Hydrochloride); Carnaculin (Pancreas Extract); Xalatan; Juvela (Tocopherol); Adona (Carbazochrome Sodium Sulfonate); Mikelan (Carteolol Hydrochloride); Hyalonsan (Hyaluronic Acid); Trusopt; Diamox
Possible Macugen side effects in 85 year old female
Reported by a physician from Slovakia (Slovak Republic) on 2012-03-19
Patient: 85 year old female
Reactions: Confusional State, Subdural Haematoma, Head Injury, RED Blood Cell Count Decreased, Fall, Loss of Consciousness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Tarka; Fraxiparin (Heparin-Fraction, Calcium Salt); ALL Other Therapeutic Products; Betaserc (Betahistine Hydrochloride); ALL Other Therapeutic Products; Cavinton (Vinpocetine); Metformin Hydrochloride; Calcium Carbonate
Possible Macugen side effects in 78 year old male
Reported by a physician from Japan on 2012-03-19
Patient: 78 year old male
Reactions: Arrhythmia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Tazin (Carbazochrome Sodium Sulfonate); Carnaculin (Pancreas Extract); Lomefloxacin Hydrochloride (Lomefloxacin Hydrochloride); Pranoprofen (Pranoprofen); Betamethasone
Possible Macugen side effects in 81 year old female
Reported by a physician from Japan on 2012-03-14
Patient: 81 year old female, weighing 41.0 kg (90.2 pounds)
Reactions: Retinal Haemorrhage
Drug(s) suspected as cause:
Macugen
Dosage: 0.3mg, single, intraocular
Indication: Choroidal Neovascularisation
Start date: 2010-12-22
Macugen
Dosage: 0.3mg, single, intraocular
Indication: AGE-Related Macular Degeneration
Start date: 2010-12-22
Other drugs received by patient: Adona (Carbazochrome Sodium Sulfonate); Kary UNI (Pirenoxine); Levofloxacin
Possible Macugen side effects in male
Reported by a physician from Spain on 2012-03-05
Patient: male
Reactions: Sudden Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 76 year old female
Reported by a physician from Italy on 2012-03-02
Patient: 76 year old female
Reactions: Upper Limb Fracture, Fall
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Combisartan (Hydrochlorothiazide, Valsartan); Aspirin; Simvastatin; Methylprednisolone; Pantoprazole
Possible Macugen side effects in male
Reported by a physician from Spain on 2012-03-02
Patient: male
Reactions: Cardiac Failure
Adverse event resulted in: death
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 95 year old male
Reported by a consumer/non-health professional from India on 2012-02-15
Patient: 95 year old male
Reactions: Hypertension, Transient Ischaemic Attack
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in male
Reported by a consumer/non-health professional from United States on 2012-02-09
Patient: male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Avastin
Indication: AGE-Related Macular Degeneration
Start date: 2005-11-05
End date: 2006-05-02
Lucentis
Indication: AGE-Related Macular Degeneration
Start date: 2004-12-05
End date: 2006-12-06
Macugen
Indication: AGE-Related Macular Degeneration
Start date: 2005-02-18
End date: 2005-09-27
Other drugs received by patient: Glipizide; Avapro; Coumadin; Flomax; Preservision Lutein
Possible Macugen side effects in 86 year old male
Reported by a physician from France on 2012-01-23
Patient: 86 year old male, weighing 80.0 kg (176.0 pounds)
Reactions: Vitreous Fibrin
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 81 year old male
Reported by a physician from Japan on 2012-01-13
Patient: 81 year old male
Reactions: Retinal Haemorrhage, Visual Acuity Reduced
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Dosage: 0.3 mg, intraocular
Indication: AGE-Related Macular Degeneration
Start date: 2010-01-28
End date: 2010-01-28
Macugen
Dosage: 0.3 mg, intraocular
Indication: Choroidal Neovascularisation
Start date: 2010-01-28
End date: 2010-01-28
Other drugs received by patient: Levofloxacin; Flomox (Cefcapene Pivoxil Hydrochloride)
Possible Macugen side effects in 81 year old male
Reported by a physician from Japan on 2012-01-06
Patient: 81 year old male
Reactions: Retinal Haemorrhage, Visual Acuity Reduced
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 74 year old male
Reported by a physician from Japan on 2012-01-05
Patient: 74 year old male
Reactions: Retinal Pigment Epithelial Tear, Visual Acuity Reduced
Drug(s) suspected as cause:
Macugen
Dosage: 0.3 mg, intraocular
Indication: Choroidal Neovascularisation
Start date: 2008-12-24
End date: 2008-12-24
Macugen
Dosage: 0.3 mg, intraocular
Indication: AGE-Related Macular Degeneration
Start date: 2008-12-24
End date: 2008-12-24
Other drugs received by patient: Moxifloxacin HCL; Moxifloxacin HCL; Xylcoaine (Lidocaine Hydrochloride); Isodine (Povidone-Iodine); Mydrin P (Phenylephrine Hydrochloride, Tropicamide)
Possible Macugen side effects in 72 year old male
Reported by a physician from Japan on 2011-12-27
Patient: 72 year old male, weighing 59.0 kg (129.8 pounds)
Reactions: Intraocular Pressure Increased, Gastritis
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Mucosta (Rebamipide); Juvela (Tocopherol); Adona (Carbazochrome Sodium Sulfonate); Mikelan (Cartelol Hydrochloride); Carnaculin (Pancreas Extract); Diamox; Aspara K (Aspartate Potassium); Methycobal (Mecobalamin); Trusopt; Rinderon A (Betamethasone Sodium Phosphate, Neomycin Sulfate); Lomefloxacin Hydrochloride (Lomefloxacin Hydrochloride); Hyalonsan (Hyaluronic Acid); Bronuck (Bromfenac Sodium); Xalatan
Possible Macugen side effects in female
Reported by a individual with unspecified qualification from United States on 2011-12-08
Patient: female
Reactions: Dysphagia, Drug Ineffective, Ocular Discomfort, Injection Site Discharge, Local Swelling, Hypertension
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Percocet; Glimepiride; Aspirin; Synthroid
Possible Macugen side effects in 82 year old male
Reported by a physician from Japan on 2011-11-28
Patient: 82 year old male
Reactions: Cerebral Infarction
Drug(s) suspected as cause:
Macugen
Dosage: 0.3 mg into the left eye, intraocular
Indication: Choroidal Neovascularisation
Start date: 2010-05-25
Macugen
Dosage: 0.3 mg into the left eye, intraocular
Indication: AGE-Related Macular Degeneration
Start date: 2010-05-25
Other drugs received by patient: Levofloxacin
Possible Macugen side effects in 90 year old male
Reported by a physician from Japan on 2011-11-16
Patient: 90 year old male, weighing 51.0 kg (112.2 pounds)
Reactions: Cerebral Infarction, Blood Pressure Systolic Increased
Adverse event resulted in: death
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Levofloxacin; Humalin (Insulin); Urief (Silodosin); Bromfenac Sodium (Bromfenac Sodium); Fulcaliq (Amino Acids Nos, Electrolytes Nos, Glucose, Vitamins Nos); Xylocaine
Possible Macugen side effects in 72 year old female
Reported by a physician from Japan on 2011-11-14
Patient: 72 year old female, weighing 59.0 kg (129.8 pounds)
Reactions: Intraocular Pressure Increased
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Methycobal (Mecobalamin); Bronuck (Bromfenac Sodium); Carnaculin (Pancreas Extract); Adona (Carbazochrome Sodium Sulfonate); Rinderon A (Betamethasone Sodium Phosphate, Neomycin Sulfate); Mikelan (Carteolol Hydrochloride); Lomefloxacin Hydrochloride (Lomefloxacin Hydrochloride); Xalatan; Mucosta (Rebamipide); Hyalonsan (Hyaluronic Acid); Diamox; Juvela (Tocopherol); Trusopt; Aspara K (Aspartate Potassium)
Possible Macugen side effects in female
Reported by a physician from Japan on 2011-11-14
Patient: female
Reactions: Palpitations, Drug Ineffective, Oedema, Injection Site Pain, Visual Acuity Reduced, Blindness
Drug(s) suspected as cause:
Macugen
Possible Macugen side effects in 80 year old male
Reported by a physician from Japan on 2011-11-03
Patient: 80 year old male, weighing 42.0 kg (92.4 pounds)
Reactions: Vitreous Haemorrhage
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Macugen
Other drugs received by patient: Pansporin T (Cefotiam Hexetil Hydrochloride); Adona (Carbazochrome Sodium Sulfonate; Bestron (Cefmenoxime Hydrochloride); Gatifloxacin
|