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Methimazole (Methimazole) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Methimazole and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (80)
Death (4)
Life Threatening Events (7)

Reports by Reaction Type

Pyrexia (14)Agranulocytosis (12)Pruritus (7)Chills (7)Renal Failure Acute (7)Pneumonia (6)Pancytopenia (6)Hyperthyroidism (6)Oropharyngeal Pain (5)Arthralgia (5)Pancreatitis Acute (4)Drug Ineffective (4)

Below are a few examples of reports where side effects / adverse reactions may be related to Methimazole. For a complete list or a specific selection of reports, please use the links above.

Possible Methimazole side effects in 85 year old female

Reported by a consumer/non-health professional from United States on 2012-08-23

Patient: 85 year old female, weighing 79.8 kg (175.6 pounds)

Reactions: DRY Mouth, Incorrect Dose Administered

Drug(s) suspected as cause:
Aspirin
    Dosage: 81 mg, unk

Detrol LA
    Dosage: 4 mg, daily at night
    Indication: Urinary Incontinence

Metoprolol Tartrate
    Dosage: 100 mg, daily
    Indication: Hypertension

Calcium Carbonate
    Dosage: unk

Lovastatin
    Dosage: 40 mg, daily
    Indication: Blood Cholesterol Increased

Centrum
    Dosage: unk

Diltiazem HCL
    Dosage: 240 mg, daily
    Indication: Drug Therapy

Vitamin B-12
    Dosage: unk

Isosorbide Mononitrate
    Dosage: 50 mg, daily
    Indication: Angina Pectoris

Methimazole
    Dosage: 05 mg, daily
    Indication: Thyroid Disorder



Possible Methimazole side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21

Patient: 51 year old male

Reactions: Joint Effusion, Pyrexia, Polyarthritis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 51 year old male

Reactions: Arthralgia, Abasia, Polyarthritis, Joint Effusion, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 30 year old female

Reported by a physician from Poland on 2012-08-15

Patient: 30 year old female

Reactions: Insulin Autoimmune Syndrome, Hypoglycaemic Coma

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Captopril
    Dosage: 75mg daily
    Indication: Hypertension

Methimazole
    Dosage: 30mg daily
    Indication: Insulin Autoimmune Syndrome



Possible Methimazole side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-08

Patient: 31 year old female

Reactions: LIP Swelling, Pruritus, Drug Ineffective, Conjunctivitis, Mouth Ulceration, Dermatitis Bullous, Laryngeal Inflammation, Reticulocyte Percentage Increased, Oral Mucosal Blistering, Haptoglobin Decreased, Drug Hypersensitivity, Coombs Test Positive, Blood Pressure Diastolic Increased, Haemoglobin Decreased, Mucosal Erosion, Dysphonia, Systemic Lupus Erythematosus, Lupus Nephritis, Haemolytic Anaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 50 year old female

Reported by a pharmacist from United States on 2012-08-03

Patient: 50 year old female, weighing 45.0 kg (99.0 pounds)

Reactions: Drug Level Above Therapeutic, Drug Interaction, Transient Ischaemic Attack, Hyperthyroidism

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tegretol
    Dosage: 400 mg qam po 200 mg bid@noon and mn po chronic
    Administration route: Oral
    Indication: Convulsion

Methimazole
    Dosage: methimazole 10 mg po bid
    Administration route: Oral

Other drugs received by patient: CA + VIT D; Vitamin D; Propranolol



Possible Methimazole side effects in 80 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-10

Patient: 80 year old female

Reactions: Pancreatitis Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Aspirin



Possible Methimazole side effects in 30 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-07-06

Patient: 30 year old female

Reactions: Insulin Autoimmune Syndrome, Hypoglycaemia, Premature Menopause, Hypertension

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methimazole
    Dosage: 30 mg, qd, po
    Administration route: Oral
    Indication: Basedow's Disease

Captopril
    Dosage: 75 mg, qd
    Indication: Hypertension

Other drugs received by patient: Estrogen Replacement Therapy



Possible Methimazole side effects in female

Reported by a individual with unspecified qualification from United States on 2012-07-05

Patient: female

Reactions: Stomatitis, Pruritus, Neutrophil Count Abnormal, Tonsillitis, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 78 year old male

Reported by a physician from Germany on 2012-06-25

Patient: 78 year old male

Reactions: Pancreatitis, Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ranolazine
    Dosage: 375 mg, unk
    Administration route: Oral
    Indication: Arrhythmia Prophylaxis
    Start date: 2012-03-08
    End date: 2012-04-10

Ramipril
    Dosage: 2.5 mg, qd
    Administration route: Oral
    Indication: Hypertension

Methimazole
    Indication: Hyperthyroidism

Other drugs received by patient: Digitoxin TAB; Torsemide; Planum / 00393701 /; Bisoprolol; Marcumar; Enoxaparin Sodium; Hydrochlorothiazide; Irenat



Possible Methimazole side effects in 52 year old female

Reported by a individual with unspecified qualification from Poland on 2012-06-19

Patient: 52 year old female

Reactions: Agranulocytosis, Drug Ineffective, Hyperthyroidism

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Ribavirin
    Dosage: dose reduced

Peginterferon Alfa-2B
    Indication: Hepatitis C

Ribavirin
    Indication: Hepatitis C

Methimazole
    Indication: Hyperthyroidism



Possible Methimazole side effects in 60 year old male

Reported by a pharmacist from United States on 2012-06-12

Patient: 60 year old male, weighing 58.0 kg (127.6 pounds)

Reactions: Neutrophil Count Decreased

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 18 year old female

Reported by a health professional (non-physician/pharmacist) from China on 2012-06-04

Patient: 18 year old female, weighing 47.0 kg (103.4 pounds)

Reactions: Pancreatitis Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole
    Dosage: 20 mg;qd; 10 mg;x1; 10 mg;xi; 10 mg;bid;
    Indication: Basedow's Disease
    Start date: 2009-01-01

Methimazole
    Dosage: 20 mg;qd; 10 mg;x1; 10 mg;xi; 10 mg;bid;
    Indication: Basedow's Disease
    Start date: 2011-02-21

Methimazole
    Dosage: 20 mg;qd; 10 mg;x1; 10 mg;xi; 10 mg;bid;
    Indication: Basedow's Disease
    Start date: 2011-03-02

Methimazole
    Dosage: 20 mg;qd; 10 mg;x1; 10 mg;xi; 10 mg;bid;
    Indication: Basedow's Disease
    Start date: 2011-05-17



Possible Methimazole side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-05-30

Patient: 41 year old male, weighing 65.0 kg (143.0 pounds)

Reactions: Multi-Organ Failure, Acute Hepatic Failure, Hepatitis Fulminant

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-05-30

Patient: 41 year old male, weighing 65.0 kg (143.0 pounds)

Reactions: Multi-Organ Failure, Acute Hepatic Failure, Hepatitis Fulminant

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-05-29

Patient: 41 year old male, weighing 65.0 kg (143.0 pounds)

Reactions: Jaundice, Disseminated Intravascular Coagulation, Thyrotoxic Crisis, Acidosis, Haemodynamic Instability, Multi-Organ Failure, Dyspepsia, Hepatorenal Syndrome, Acute Respiratory Distress Syndrome, Hypoxia, Lethargy, Renal Failure Acute, Hepatitis Fulminant, Acute Pulmonary Oedema, Cardiac Murmur, Metabolic Acidosis, Nausea, Atrial Fibrillation, Coagulation Time Shortened, Cardiac Failure, Epigastric Discomfort, Fibrinolysis Increased, Heart Rate Increased, Sepsis, Acute Hepatic Failure, Depressed Level of Consciousness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Propranolol; Propranolol



Possible Methimazole side effects in 78 year old male

Reported by a physician from Germany on 2012-05-14

Patient: 78 year old male

Reactions: Pancreatitis, Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole
    Indication: Hyperthyroidism

Ranolazine
    Dosage: 375 mg, unk
    Administration route: Oral
    Indication: Arrhythmia Prophylaxis
    Start date: 2012-03-08
    End date: 2012-04-10

Ramipril
    Dosage: 2.5 mg, qd
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Bisoprolol Fumarate; Irenat; Digitoxin TAB; Torsemide; Marcumar; Enoxaparin Sodium; Hydrochlorothiazide; Planum / 00393701 /



Possible Methimazole side effects in 78 year old male

Reported by a physician from Germany on 2012-05-11

Patient: 78 year old male

Reactions: Pancreatitis, Blood Creatinine Increased, Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole
    Indication: Hyperthyroidism

Ramipril
    Dosage: 2.5 mg, qd
    Administration route: Oral
    Indication: Hypertension

Ranolazine
    Dosage: 375 mg, unk
    Administration route: Oral
    Indication: Arrhythmia Prophylaxis
    Start date: 2012-03-08
    End date: 2012-04-10

Other drugs received by patient: Bisoprolol Fumarate; Hydrochlorothiazide; Torsemide; Enoxaparin Sodium; Planum / 00393701 /; Marcumar; Irenat; Digitoxin TAB



Possible Methimazole side effects in 52 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-10

Patient: 52 year old female

Reactions: Lymphadenopathy, Dysphagia, Trismus, Chills, Mouth Ulceration, Pyrexia, Oropharyngeal Pain, Pallor, Tonsillitis Bacterial, Agranulocytosis, Lymph Node Pain, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Peginterferon Alfa-2B
    Dosage: 150 ug, qd
    Indication: Hepatitis C

Other drugs received by patient: Ribavirin



Possible Methimazole side effects in female

Reported by a individual with unspecified qualification from Germany on 2012-05-09

Patient: female, weighing 60.0 kg (132.0 pounds)

Reactions: Anxiety, Panic Attack, Hyperthyroidism

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Pegasys
    Indication: Hepatitis C
    Start date: 2012-04-05

Alisporivir
    Administration route: Oral
    Indication: Hepatitis C
    Start date: 2011-04-05

Copegus
    Indication: Hepatitis C
    Start date: 2011-04-05

Levothyroxine Sodium
    Indication: Product Used FOR Unknown Indication

Methimazole
    Indication: Hyperthyroidism
    Start date: 2011-10-06
    End date: 2012-01-17



Possible Methimazole side effects in 27 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-08

Patient: 27 year old female

Reactions: Nasopharyngitis, Chills, Oropharyngeal Pain, Pyrexia, Pallor, Band Neutrophil Percentage Decreased, Oedema Mucosal, Neutrophil Percentage Decreased, Thrombocytopenia, Monocyte Percentage Increased, Epistaxis, Eosinophil Count Decreased, Haemoglobin Decreased, Agranulocytosis, Arthralgia, Hyperthyroidism, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Peginterferon Alfa-2A
    Dosage: 180 ug once weekly
    Indication: Hepatitis C

Ribavirin
    Dosage: 1.0 g/day
    Indication: Hepatitis C

Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Propylthiouracil
    Dosage: 50 mg/day
    Indication: Hyperthyroidism



Possible Methimazole side effects in 52 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-08

Patient: 52 year old female

Reactions: Dysphagia, Trismus, Drug Ineffective, Anaemia, Tonsillitis, Exercise Tolerance Decreased, Irritability, Mucosal Ulceration, Agranulocytosis, Insomnia, Enterococcus Test Positive, Hyperthyroidism

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Peginterferon Alfa-2B
    Dosage: 150 ug once a week
    Indication: Hepatitis C

Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Ribavirin
    Dosage: 1.2 g/day, 1 g/day (dose reduced)
    Indication: Hepatitis C



Possible Methimazole side effects in 32 year old female

Reported by a individual with unspecified qualification from China on 2012-05-07

Patient: 32 year old female

Reactions: Maternal Exposure During Pregnancy, Abortion Induced, Pregnancy

Drug(s) suspected as cause:
Methimazole
    Dosage: (2 in 1 d)
    Indication: Hyperthyroidism
    Start date: 2011-03-01
    End date: 2011-01-01

Dexamethasone
    Indication: Nasopharyngitis

Amidopyrine Compound (Aminophenazone) (Amidopyrine)
    Indication: Nasopharyngitis

Ribavirin
    Indication: Nasopharyngitis

Levothyroxine Sodium
    Dosage: (1 df, 1 in 1 d)
    Indication: Hyperthyroidism
    Start date: 2011-03-01
    End date: 2011-01-01

Analgin (Metamizole Sodium) (Analgin)
    Indication: Nasopharyngitis



Possible Methimazole side effects in 69 year old female

Reported by a pharmacist from United States on 2012-04-27

Patient: 69 year old female

Reactions: Dyspnoea, Pulmonary Congestion, Pyrexia

Drug(s) suspected as cause:
Methimazole
    Administration route: Oral
    Indication: Hyperthyroidism
    Start date: 2011-08-25
    End date: 2011-09-16

Methimazole
    Administration route: Oral
    Start date: 2011-09-17

Other drugs received by patient: Hydrochlorothiazide; Tylenol; Zolpidem



Possible Methimazole side effects in 40 year old female

Reported by a consumer/non-health professional from United States on 2012-04-27

Patient: 40 year old female

Reactions: Ageusia

Drug(s) suspected as cause:
Methimazole
    Administration route: Oral
    Start date: 2011-03-17

Methimazole
    Administration route: Oral
    Indication: Basedow's Disease
    Start date: 2011-02-11
    End date: 2011-03-16

Other drugs received by patient: Bystolic



Possible Methimazole side effects in 66 year old female

Reported by a consumer/non-health professional from United States on 2012-04-27

Patient: 66 year old female

Reactions: Infection

Drug(s) suspected as cause:
Methimazole
    Administration route: Oral
    Start date: 2011-10-30
    End date: 2011-10-31

Methimazole
    Administration route: Oral
    Indication: Hyperthyroidism
    Start date: 2011-09-19
    End date: 2011-01-01



Possible Methimazole side effects in

Reported by a pharmacist from United States on 2012-04-27

Patient:

Reactions: Ageusia

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 55 year old female

Reported by a pharmacist from United States on 2012-04-27

Patient: 55 year old female

Reactions: Drug Ineffective

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in female

Reported by a consumer/non-health professional from United States on 2012-04-27

Patient: female

Reactions: Alopecia

Drug(s) suspected as cause:
Methimazole
    Administration route: Oral
    Indication: Hyperthyroidism
    Start date: 2011-08-01
    End date: 2011-08-01

Methimazole
    Administration route: Oral
    Start date: 2011-09-15

Other drugs received by patient: Diovan; Cymbalta; Klonopin



Possible Methimazole side effects in female

Reported by a consumer/non-health professional from United States on 2012-04-27

Patient: female

Reactions: Drug Effect Decreased

Drug(s) suspected as cause:
Methimazole

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