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Methimazole (Methimazole) - Agranulocytosis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Agranulocytosis (12)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methimazole where reactions include agranulocytosis. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Methimazole side effects in 52 year old female

Reported by a individual with unspecified qualification from Poland on 2012-06-19

Patient: 52 year old female

Reactions: Agranulocytosis, Drug Ineffective, Hyperthyroidism

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Ribavirin
    Dosage: dose reduced

Peginterferon Alfa-2B
    Indication: Hepatitis C

Ribavirin
    Indication: Hepatitis C

Methimazole
    Indication: Hyperthyroidism



Possible Methimazole side effects in 52 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-10

Patient: 52 year old female

Reactions: Lymphadenopathy, Dysphagia, Trismus, Chills, Mouth Ulceration, Pyrexia, Oropharyngeal Pain, Pallor, Tonsillitis Bacterial, Agranulocytosis, Lymph Node Pain, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Peginterferon Alfa-2B
    Dosage: 150 ug, qd
    Indication: Hepatitis C

Other drugs received by patient: Ribavirin



Possible Methimazole side effects in 52 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-08

Patient: 52 year old female

Reactions: Dysphagia, Trismus, Drug Ineffective, Anaemia, Tonsillitis, Exercise Tolerance Decreased, Irritability, Mucosal Ulceration, Agranulocytosis, Insomnia, Enterococcus Test Positive, Hyperthyroidism

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Peginterferon Alfa-2B
    Dosage: 150 ug once a week
    Indication: Hepatitis C

Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Ribavirin
    Dosage: 1.2 g/day, 1 g/day (dose reduced)
    Indication: Hepatitis C



Possible Methimazole side effects in 27 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-05-08

Patient: 27 year old female

Reactions: Nasopharyngitis, Chills, Oropharyngeal Pain, Pyrexia, Pallor, Band Neutrophil Percentage Decreased, Oedema Mucosal, Neutrophil Percentage Decreased, Thrombocytopenia, Monocyte Percentage Increased, Epistaxis, Eosinophil Count Decreased, Haemoglobin Decreased, Agranulocytosis, Arthralgia, Hyperthyroidism, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Peginterferon Alfa-2A
    Dosage: 180 ug once weekly
    Indication: Hepatitis C

Ribavirin
    Dosage: 1.0 g/day
    Indication: Hepatitis C

Methimazole
    Dosage: 20 mg/day
    Indication: Hyperthyroidism

Propylthiouracil
    Dosage: 50 mg/day
    Indication: Hyperthyroidism



Possible Methimazole side effects in 68 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-02-14

Patient: 68 year old female

Reactions: Hyperbilirubinaemia, Excoriation, Chills, Pain, Pancytopenia, Pyrexia, Agranulocytosis, Cyanosis, Wound Infection Pseudomonas, Swelling, Cholecystitis, Necrotising Fasciitis, Azotaemia, Blister

Drug(s) suspected as cause:
Methimazole
    Dosage: 15 mg/day

Methimazole
    Dosage: 15 mg, bid

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 68 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-02-07

Patient: 68 year old female

Reactions: Hyperbilirubinaemia, Excoriation, Pain, Chills, Pancytopenia, Pyrexia, Agranulocytosis, Wound Infection Pseudomonas, Cyanosis, Swelling, Cholecystitis, Azotaemia, Necrotising Fasciitis, Blister

Drug(s) suspected as cause:
Methimazole
    Dosage: 15 mg, bid

Methimazole
    Dosage: 15 mg/day

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 68 year old female

Reported by a physician from Taiwan, Province of China on 2011-12-21

Patient: 68 year old female

Reactions: White Blood Cell Count Decreased, Agranulocytosis, Excoriation, Limb Injury, Fall, Necrotising Fasciitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Propranolol



Possible Methimazole side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-11-03

Patient: 53 year old male

Reactions: Blood Pressure Increased, Agranulocytosis, Malaise, Chills, Heart Rate Increased, Pyrexia, Pharyngeal Erythema

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Levothyroxine Sodium; Insulin



Possible Methimazole side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2011-10-20

Patient: 44 year old female

Reactions: Agranulocytosis, Histiocytosis Haematophagic, Pseudomonas Infection, Necrosis, Wound, Pyrexia, Oropharyngeal Pain

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2011-10-18

Patient: 44 year old female

Reactions: Agranulocytosis, Histiocytosis Haematophagic

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole



Possible Methimazole side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-10-06

Patient: 53 year old male

Reactions: Blood Pressure Increased, Agranulocytosis, Malaise, Heart Rate Increased, Chills, Pyrexia, Pharyngeal Erythema

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

Other drugs received by patient: Levothyroxine Sodium



Possible Methimazole side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2011-10-05

Patient: 44 year old female

Reactions: Agranulocytosis, Impaired Healing, Blood Culture Positive, Pseudomonas Infection, Culture Throat Positive, Pyrexia, Oropharyngeal Pain, Hyperthyroidism, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methimazole

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