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Phenytoin (Phenytoin) - Drug Rash With Eosinophilia and Systemic Symptoms - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Drug Rash With Eosinophilia and Systemic Symptoms (43)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Phenytoin where reactions include drug rash with eosinophilia and systemic symptoms. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 43   Next >>

Possible Phenytoin side effects in 38 year old female

Reported by a physician from United States on 2012-08-16

Patient: 38 year old female

Reactions: Myositis, Dermatitis Exfoliative, Drug Rash With Eosinophilia and Systemic Symptoms, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Diphenhydramine Hydrochloride; Phenobarbital; Diazepam



Possible Phenytoin side effects in 16 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 16 year old male

Reactions: Sepsis, Toxic Epidermal Necrolysis, Rash Morbilliform, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 20 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 20 year old male

Reactions: Sepsis, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms, Dermatitis Exfoliative

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 61 year old female

Reported by a individual with unspecified qualification from Japan on 2012-08-08

Patient: 61 year old female

Reactions: Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms

Drug(s) suspected as cause:
Clonazepam
    Dosage: dosage is uncertain.
    Administration route: Oral

Clonazepam
    Dosage: dosage is uncertain.
    Administration route: Oral

Valproate Sodium
    Dosage: dosage is uncertain.
    Administration route: Oral
    Indication: Postresuscitation Encephalopathy

Phenytoin
    Dosage: dosage is uncertain.
    Indication: Postresuscitation Encephalopathy

Clonazepam
    Dosage: dosage is uncertain.
    Administration route: Oral
    Indication: Postresuscitation Encephalopathy

Other drugs received by patient: Prednisolone



Possible Phenytoin side effects in 13 year old female

Reported by a health professional (non-physician/pharmacist) from Spain on 2012-07-11

Patient: 13 year old female

Reactions: Escherichia Urinary Tract Infection, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenobarbital TAB
    Indication: Encephalitis

Phenobarbital TAB
    Indication: Epilepsy

Levetiracetam
    Indication: Epilepsy

Levetiracetam
    Indication: Encephalitis

Phenytoin
    Indication: Epilepsy

Phenytoin
    Indication: Encephalitis

Prednisone TAB
    Dosage: 2 mg/kg;qd
    Indication: Epilepsy

Prednisone TAB
    Dosage: 2 mg/kg;qd
    Indication: Encephalitis

Immune Globulin (Human)
    Dosage: biw
    Indication: Encephalitis

Immune Globulin (Human)
    Dosage: biw
    Indication: Epilepsy



Possible Phenytoin side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 70 year old female

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms, Herpes Zoster, Infection Reactivation

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 54 year old male

Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2010-12-02

Omeprazole
    Start date: 2011-03-12



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 54 year old male

Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Omeprazole
    Start date: 2011-03-12

Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2010-12-02



Possible Phenytoin side effects in 40 year old male

Reported by a health professional (non-physician/pharmacist) from Spain on 2012-07-02

Patient: 40 year old male

Reactions: Pruritus, Lymphadenopathy, Lymphocyte Transformation Test Positive, Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms, Eosinophilia, Hepatic Enzyme Increased, Rash Erythematous

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ceftriaxone
    Dosage: 2 g, q12h
    Indication: Status Epilepticus

Metronidazole
    Dosage: 100 mg, q12h
    Indication: Status Epilepticus

Phenytoin
    Dosage: 100 mg, q12h
    Indication: Status Epilepticus



Possible Phenytoin side effects in 46 year old male

Reported by a physician from Belgium on 2012-05-30

Patient: 46 year old male

Reactions: Human Herpesvirus 6 Infection, Drug Rash With Eosinophilia and Systemic Symptoms

Drug(s) suspected as cause:
Antibiotics
    Indication: Meningitis Streptococcal

Phenytoin
    Indication: Meningitis Streptococcal

Dexamethasone
    Indication: Meningitis Streptococcal

Methylprednisolone

Other drugs received by patient: Antibiotics



Possible Phenytoin side effects in

Reported by a individual with unspecified qualification from Belgium on 2012-05-29

Patient:

Reactions: Epstein-Barr Virus Infection, Drug Rash With Eosinophilia and Systemic Symptoms, Human Herpesvirus 6 Infection, Immunosuppression

Drug(s) suspected as cause:
Dexamethasone
    Dosage: unk, unknown
    Indication: Meningitis Bacterial

Dexamethasone
    Indication: Streptococcal Infection

Phenytoin
    Dosage: unk, unknown
    Indication: Meningitis Bacterial

Phenytoin
    Indication: Streptococcal Infection

Other drugs received by patient: Antibiotics; Antibiotics



Possible Phenytoin side effects in

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18

Patient:

Reactions: Dehydration, Drug Rash With Eosinophilia and Systemic Symptoms

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18

Patient: 54 year old male

Reactions: Amylase Increased, Hyperbilirubinaemia, Blood Trypsin Increased, Alanine Aminotransferase Increased, Toxic Epidermal Necrolysis, Lymphocyte Stimulation Test Positive, Corneal Epithelium Defect, Blood Elastase Increased, Drug Rash With Eosinophilia and Systemic Symptoms, Gastric Haemorrhage, Multi-Organ Failure, Renal Impairment, Dialysis, Blood Disorder, Hypogammaglobulinaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin
    Indication: Convulsion
    Start date: 2010-12-02

Omeprazole
    Indication: Melaena

Omeprazole
    Indication: Gastric Haemorrhage



Possible Phenytoin side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18

Patient: 70 year old female

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms, Herpes Zoster

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18

Patient:

Reactions: Dehydration, Drug Rash With Eosinophilia and Systemic Symptoms

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 22 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-11

Patient: 22 year old female

Reactions: Liver Injury, Coagulopathy, Anticonvulsant Drug Level Increased, Leukocytosis, Hepatitis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Levetiracetam
    Indication: Convulsion Prophylaxis

Phenytoin
    Indication: Convulsion

Other drugs received by patient: Acetaminophen; Morphine



Possible Phenytoin side effects in 42 year old male

Reported by a physician from Japan on 2012-04-18

Patient: 42 year old male, weighing 84.0 kg (184.8 pounds)

Reactions: Glioblastoma Multiforme, Hepatorenal Failure, Neoplasm Progression, Status Epilepticus, Drug Rash With Eosinophilia and Systemic Symptoms, Multi-Organ Failure, Diarrhoea, Acute Respiratory Distress Syndrome

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Depakene
    Dosage: po
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2006-11-11
    End date: 2009-09-07

Phenytoin
    Indication: Status Epilepticus
    Start date: 2009-06-25
    End date: 2009-09-07

Temodal
    Dosage: 75 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2009-09-28
    End date: 2010-05-04

Temodal
    Dosage: 75 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2010-06-11
    End date: 2010-10-05

Temodal
    Dosage: 75 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2007-01-25
    End date: 2009-05-18

Temodal
    Dosage: 75 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po, 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2006-11-28
    End date: 2006-12-26

Tegretol
    Dosage: po
    Administration route: Oral
    Indication: Status Epilepticus
    Start date: 2009-06-25
    End date: 2009-09-07

Other drugs received by patient: Kytril / 01178102 /; Zonisamide; Isozol; Topina (Topiramate); Phenobarbital TAB; Diprivan; Biofermin (Lactomin)



Possible Phenytoin side effects in 73 year old male

Reported by a physician from United States on 2012-04-17

Patient: 73 year old male

Reactions: Drug Hypersensitivity, Pancytopenia, Blood Disorder, Hemiparesis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 74 year old female

Reported by a physician from Taiwan, Province of China on 2012-04-06

Patient: 74 year old female

Reactions: Gastrointestinal Haemorrhage, Sepsis, Drug Rash With Eosinophilia and Systemic Symptoms, Pneumonitis

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 78 year old male

Reported by a physician from Taiwan, Province of China on 2012-04-06

Patient: 78 year old male

Reactions: Gastrointestinal Haemorrhage, Hepatic Failure, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin
    Indication: Subdural Haematoma

Phenytoin
    Indication: Cerebral Haemorrhage



Possible Phenytoin side effects in 59 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-02-03

Patient: 59 year old female

Reactions: Dyskinesia, Cerebral Atrophy, Encephalitis, Purpura, Status Epilepticus, Erythema, Pallor, Drug Rash With Eosinophilia and Systemic Symptoms, Hepatic Enzyme Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tegretol
    Dosage: unk ukn, unk
    Administration route: Oral
    Indication: Epilepsy
    End date: 2011-03-01

Tegretol
    Dosage: 600 mg, daily
    Administration route: Oral
    Start date: 2011-03-01
    End date: 2011-04-04

Valproate Sodium
    Dosage: unk ukn, unk
    Administration route: Oral
    Indication: Epilepsy

Phenytoin
    Dosage: unk ukn, unk
    Administration route: Oral
    Indication: Epilepsy



Possible Phenytoin side effects in 59 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-02-01

Patient: 59 year old female

Reactions: Dyskinesia, Cerebral Atrophy, Status Epilepticus, Drug Rash With Eosinophilia and Systemic Symptoms, Erythema, Viral Titre Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Valproic Acid
    Dosage: unk ukn, unk
    Indication: Epilepsy

Carbamazepine
    Dosage: unk ukn, unk
    Administration route: Oral
    Indication: Epilepsy

Phenytoin
    Dosage: unk ukn, unk
    Administration route: Oral
    Indication: Epilepsy



Possible Phenytoin side effects in male

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-01-27

Patient: male

Reactions: Lung Disorder, Gastrointestinal Disorder, Cytomegalovirus Infection, Drug Rash With Eosinophilia and Systemic Symptoms, Liver Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in male

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-01-27

Patient: male

Reactions: Lung Disorder, Gastrointestinal Disorder, Cytomegalovirus Infection, Drug Rash With Eosinophilia and Systemic Symptoms, Liver Disorder

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 70 year old male

Reported by a pharmacist from United States on 2012-01-26

Patient: 70 year old male, weighing 103.9 kg (228.6 pounds)

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-01-19

Patient: male

Reactions: Rhabdomyolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Phenobarbital TAB
    Administration route: Oral
    Start date: 2011-04-11
    End date: 2011-04-15

Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-11
    End date: 2011-07-05

Midazolam HCL
    Indication: Convulsion
    Start date: 2011-04-05

Thiopental Sodium
    Indication: Convulsion
    Start date: 2011-04-09
    End date: 2011-07-13

Midazolam HCL
    Start date: 2011-04-04
    End date: 2011-04-04

Topiramate
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-12
    End date: 2011-04-17

Topiramate
    Administration route: Oral
    Start date: 2011-04-12
    End date: 2011-04-17

Phenobarbital Sodium 100mg CAP
    Indication: Convulsion
    Start date: 2011-04-04
    End date: 2011-04-07

Phenobarbital TAB
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-07
    End date: 2011-04-10

Topiramate
    Administration route: Oral
    Start date: 2011-04-18

Topiramate
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-04-18

Other drugs received by patient: Valproic Acid; Valproic Acid



Possible Phenytoin side effects in 3 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-01-11

Patient: 3 year old male

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms, Hypogammaglobulinaemia, Idiosyncratic Drug Reaction

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 42 year old male

Reported by a physician from Japan on 2012-01-05

Patient: 42 year old male, weighing 84.0 kg (184.8 pounds)

Reactions: Diarrhoea, Status Epilepticus, Apparent Life Threatening Event, Drug Rash With Eosinophilia and Systemic Symptoms, Disease Progression

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Temodal
    Dosage: 75 mg/m2;qd;po 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2006-11-28
    End date: 2006-12-26

Temodal
    Dosage: 75 mg/m2;qd;po 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2007-01-25
    End date: 2009-05-18

Temodal
    Dosage: 75 mg/m2;qd;po 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2009-09-28
    End date: 2010-05-04

Temodal
    Dosage: 75 mg/m2;qd;po 150 mg/m2;qd;po
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2010-06-11
    End date: 2010-10-05

Phenytoin
    Dosage: indrp
    Indication: Status Epilepticus
    Start date: 2009-06-25

Tegretol
    Dosage: po
    Administration route: Oral
    Indication: Status Epilepticus
    Start date: 2009-06-25

Depakene
    Dosage: po
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2006-11-11

Other drugs received by patient: Kytril / 01178102 /



Possible Phenytoin side effects in male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-12-23

Patient: male

Reactions: Rhabdomyolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Thiopental Sodium
    Indication: Convulsion
    Start date: 2011-04-09
    End date: 2011-07-13

Topiramate
    Administration route: Oral
    Start date: 2011-04-12
    End date: 2011-04-17

Phenobarbital TAB
    Administration route: Oral
    Start date: 2011-04-11
    End date: 2011-04-15

Phenobarbital TAB
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-07
    End date: 2011-04-10

Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-11
    End date: 2011-07-05

Lupial
    Indication: Convulsion
    Start date: 2011-04-04
    End date: 2011-04-07

Midazolam HCL
    Start date: 2011-04-04
    End date: 2011-04-04

Midazolam HCL
    Indication: Convulsion
    Start date: 2011-04-05

Topiramate
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-04-12
    End date: 2011-04-17

Topiramate
    Administration route: Oral
    Start date: 2011-04-18

Topiramate
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-04-18

Other drugs received by patient: Valproic Acid; Valproic Acid



Possible Phenytoin side effects in 22 year old male

Reported by a health professional (non-physician/pharmacist) on 2011-12-19

Patient: 22 year old male

Reactions: Lymphadenopathy, Urine Output Decreased, Drug Rash With Eosinophilia and Systemic Symptoms, Hepatic Enzyme Increased, Speech Disorder, Hepatomegaly, Altered State of Consciousness, Splenomegaly, Meningitis Aseptic

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Phenytoin



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