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Phenytoin (Phenytoin) - Toxicity To Various Agents - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Toxicity To Various Agents (53)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Phenytoin where reactions include toxicity to various agents. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 53   Next >>

Possible Phenytoin side effects in female

Reported by a health professional (non-physician/pharmacist) from Peru on 2012-07-27

Patient: female

Reactions: Choreoathetosis, Hallucination, Visual, Dyskinesia, Toxicity To Various Agents

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Valproic Acid



Possible Phenytoin side effects in female

Reported by a health professional (non-physician/pharmacist) from Peru on 2012-07-27

Patient: female

Reactions: Chorea, Dyskinesia, Toxicity To Various Agents

Drug(s) suspected as cause:
Phenytoin
    Dosage: 200 mg, 1x/day
    Indication: Epilepsy

Phenytoin
    Dosage: 300 mg, 1x/day



Possible Phenytoin side effects in 4 year old

Reported by a health professional (non-physician/pharmacist) from India on 2012-07-18

Patient: 4 year old

Reactions: Toxicity To Various Agents, Accidental Exposure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 21 year old male

Reported by a health professional (non-physician/pharmacist) from India on 2012-07-10

Patient: 21 year old male

Reactions: Headache, Pyrexia, Treatment Noncompliance, Cerebellar Atrophy, Speech Disorder, Nystagmus, Anticonvulsant Drug Level Increased, Coordination Abnormal, Vomiting, Ataxia, Toxicity To Various Agents, Grand MAL Convulsion, Intention Tremor, Hypotonia, Vision Blurred, Gait Disturbance

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Methaqualone TAB



Possible Phenytoin side effects in 37 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06

Patient: 37 year old female

Reactions: Accidental Death, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin
    Indication: Product Used FOR Unknown Indication

Keppra
    Indication: Product Used FOR Unknown Indication

Fluoxetine
    Indication: Product Used FOR Unknown Indication

Methadone Hydrochloride
    Indication: Product Used FOR Unknown Indication



Possible Phenytoin side effects in 53 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-02

Patient: 53 year old female

Reactions: Hypothermia, Toxicity To Various Agents

Drug(s) suspected as cause:
Phenytoin
    Dosage: unk
    Indication: Schizoaffective Disorder

Risperidone
    Dosage: unk
    Indication: Schizoaffective Disorder



Possible Phenytoin side effects in 21 year old male

Reported by a health professional (non-physician/pharmacist) from India on 2012-06-25

Patient: 21 year old male

Reactions: Cerebellar Ataxia, Drug Interaction, Toxicity To Various Agents, Speech Disorder, Intention Tremor, Nystagmus, Hypotonia, Vision Blurred, Gait Disturbance, Coordination Abnormal

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Phenytoin
    Dosage: 300 mg;qd;po
    Administration route: Oral
    Indication: Epilepsy

Methaqualone (Methaqualone)
    Dosage: 250 mg;bid



Possible Phenytoin side effects in 21 year old male

Reported by a physician from India on 2012-06-22

Patient: 21 year old male

Reactions: Ataxia, Drug Interaction, Toxicity To Various Agents, Cerebellar Atrophy, Grand MAL Convulsion, Dysarthria, Anticonvulsant Drug Level Above Therapeutic, Intention Tremor, Nystagmus, Hypotonia, Vision Blurred, Gait Disturbance, Coordination Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methaqualone TAB
    Dosage: 250 mg;bid;

Phenytoin
    Dosage: 300 mg;qd; 300 mg;qd;
    Indication: Epilepsy

Phenytoin
    Dosage: 300 mg;qd; 300 mg;qd;
    Indication: Epilepsy



Possible Phenytoin side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-21

Patient: 53 year old male

Reactions: Electrocardiogram ST Segment Depression, Anaesthetic Complication, Coronary Artery Disease, Drug Interaction, Toxicity To Various Agents, Electrocardiogram QRS Complex Abnormal, Electrocardiogram ST Segment Elevation, Haemodynamic Instability

Drug(s) suspected as cause:
Valproate Sodium
    Dosage: unk, intravenous
    Indication: Status Epilepticus

Phenytoin
    Dosage: unk
    Indication: Status Epilepticus

Other drugs received by patient: Inotropic Agents



Possible Phenytoin side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-14

Patient: 53 year old male

Reactions: Electrocardiogram ST Segment Depression, Coronary Artery Disease, Drug Interaction, Toxicity To Various Agents, Electrocardiogram ST Segment Elevation, Haemodynamic Instability

Drug(s) suspected as cause:
Valproate Sodium
    Dosage: intravenous (otherwise not specified)
    Indication: Status Epilepticus

Phenytoin
    Indication: Status Epilepticus

Other drugs received by patient: Inotropic Agents



Possible Phenytoin side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-05-29

Patient: 53 year old male

Reactions: Electrocardiogram Abnormal, Drug Interaction, Toxicity To Various Agents

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient possibly interacting with the suspect drug:
Valproic Acid
    Indication: Status Epilepticus



Possible Phenytoin side effects in

Reported by a consumer/non-health professional from United States on 2012-05-09

Patient:

Reactions: Product Substitution Issue, Product Quality Issue, Drug Level Increased, Anticonvulsant Drug Level Increased, Unevaluable Event, Toxicity To Various Agents, Suicidal Ideation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Dilantin
    Dosage: unk
    Indication: Convulsion
    Start date: 1997-01-01

Phenytoin
    Dosage: unk
    Indication: Convulsion



Possible Phenytoin side effects in 21 year old male

Reported by a health professional (non-physician/pharmacist) from India on 2012-04-24

Patient: 21 year old male

Reactions: Vestibular Disorder, Drug Interaction, Toxicity To Various Agents, Cerebellar Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient possibly interacting with the suspect drug:
Mandrax



Possible Phenytoin side effects in 52 year old female

Reported by a physician from Turkey on 2012-04-20

Patient: 52 year old female

Reactions: Pneumonia Aspiration, Supraventricular Tachycardia, Coma, Toxicity To Various Agents, Electroencephalogram Abnormal, Neurotoxicity, Renal Failure, Respiratory Failure, Dehydration, Acute Respiratory Distress Syndrome, Hyperthyroidism

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Diuretics
    Indication: Hypertension

Lithium Carbonate
    Indication: Bipolar Disorder

Propranolol
    Indication: Supraventricular Tachycardia

Insuline Glargine
    Indication: Diabetes Mellitus

Irbesartane
    Indication: Hypertension

Phenytoin
    Dosage: 300 mg
    Indication: Convulsion

Dexamethasone
    Indication: Supraventricular Tachycardia

Dexamethasone
    Dosage: 2 mg
    Indication: Hyperthyroidism

Chlorpromazine
    Dosage: 200 mg
    Indication: Bipolar Disorder

Propranolol
    Dosage: 160 mg
    Indication: Hyperthyroidism

Propyl-Thiouracil
    Indication: Supraventricular Tachycardia

Propyl-Thiouracil
    Dosage: 600 mg
    Indication: Hyperthyroidism



Possible Phenytoin side effects in 42 year old male

Reported by a pharmacist from United States on 2012-04-16

Patient: 42 year old male, weighing 111.0 kg (244.2 pounds)

Reactions: Nystagmus, Ataxia, Toxicity To Various Agents, Accidental Overdose

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 54 year old male

Reported by a pharmacist from United States on 2012-04-05

Patient: 54 year old male, weighing 80.9 kg (178.0 pounds)

Reactions: Product Substitution Issue, Asterixis, Ataxia, Gait Disturbance, Toxicity To Various Agents, Fall, RIB Fracture

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-03

Patient:

Reactions: Pneumonia, Overdose, Toxicity To Various Agents

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Phenytoin

Methadone HCL



Possible Phenytoin side effects in male

Reported by a physician from United States on 2012-04-02

Patient: male, weighing 2.4 kg (5.3 pounds)

Reactions: Metabolic Acidosis, Ventricular Arrhythmia, Drug Interaction, Atrioventricular Block, Toxicity To Various Agents, Sinus Bradycardia, Long QT Syndrome Congenital

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lidocaine
    Dosage: 1 mg/kg; 10 ug/kg; 40 ug/kg; 1 mg/kg;2 times; 50 ug/kg; 1 mg/kg; iv
    Indication: Ventricular Tachycardia

Amiodarone HCL
    Dosage: 1 mg/kg; 3 mg;11 times; 1 mg/kg;3 times;
    Indication: Torsade DE Pointes

Phenytoin
    Dosage: 8 mg/kg; 5 mg/kg;
    Indication: Ventricular Tachycardia

Other drugs received by patient: Potassium; Dopamine HCL; Vecuronium Bromide; Fentanyl Citrate; Magnesium; Calcium Gluconate; 5% Albumin; Esmolol HCL; Milrinone; Isoproterenol HCL



Possible Phenytoin side effects in 59 year old male

Reported by a individual with unspecified qualification from Japan on 2012-03-28

Patient: 59 year old male

Reactions: Drug Level Increased, Nausea, Condition Aggravated, Drug Interaction, Toxicity To Various Agents, Treatment Noncompliance, Convulsion, Dyslalia, Anxiety, Insomnia, Hypophagia, Dizziness, Gastrooesophageal Reflux Disease

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin
    Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
    Administration route: Oral
    Indication: Epilepsy
    Start date: 1994-01-01
    End date: 2012-02-02

Phenytoin
    Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2012-02-03
    End date: 2012-02-17

Phenytoin
    Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2012-02-18

Lansoprazole
    Dosage: 15 mg (15 mg, 1 in 1 d)
    Administration route: Oral
    Indication: Gastrooesophageal Reflux Disease
    Start date: 2011-09-02
    End date: 2012-02-09



Possible Phenytoin side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-09

Patient: male, weighing 113.4 kg (249.4 pounds)

Reactions: Drug Hypersensitivity, Ataxia, Anticonvulsant Drug Level Decreased, Toxicity To Various Agents, Thermal Burn, Suicidal Ideation, Balance Disorder, Depression

Drug(s) suspected as cause:
Phenytoin
    Dosage: unk
    Indication: Convulsion

Dilantin-125
    Dosage: 400 mg, unk
    Administration route: Oral
    Indication: Convulsion

Dilantin-125
    Dosage: 100 mg,5 per day

Keppra
    Indication: Convulsion
    Start date: 2010-06-06
    End date: 2010-06-16

Topamax
    Dosage: frequency: 2x/day,
    Indication: Convulsion
    Start date: 2010-01-01



Possible Phenytoin side effects in 64 year old female

Reported by a individual with unspecified qualification from Canada on 2012-03-08

Patient: 64 year old female

Reactions: Colon Cancer Metastatic, Ataxia, Hyperreflexia, Drug Interaction, Anticonvulsant Drug Level Decreased, Toxicity To Various Agents, Somnolence, Balance Disorder, Dizziness, Gait Disturbance

Drug(s) suspected as cause:
Fluorouracil
    Indication: Colon Cancer

Phenytoin
    Indication: Epilepsy

Other drugs received by patient: Calcium Carbonate; Venlafaxine; Etidronate Disodium; Irinotecan HCL; Docusate Sodium; Leucovorin Calcium; Cetuximab



Possible Phenytoin side effects in male

Reported by a physician from United States on 2012-02-24

Patient: male, weighing 2.4 kg (5.3 pounds)

Reactions: Neurotoxicity, Nasopharyngitis, Drug Interaction, Toxicity To Various Agents, Cardiac Disorder

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Esmolol HCL
    Dosage: 66;30;200;250;500 mcg/kg/min, intravenous drip
    Indication: Ventricular Arrhythmia

Fentanyl Citrate
    Dosage: 5 ug/kg, microgram/kilogram,
    Indication: Anaesthesia

Fentanyl Citrate
    Dosage: 5 ug/kg, microgram/kilogram,
    Indication: Arrhythmia

Phenytoin
    Dosage: 8;5mg/kg milligram(s)/kilogram, intravenous bolus
    Indication: Ventricular Arrhythmia

Lidocaine HCL
    Dosage: 1;40;50 mg/kg milligram(s)/kilogram, intravenous bolus
    Indication: Ventricular Arrhythmia

Amiodarone HCL
    Dosage: 1;3mg/dose, intravenous bolus
    Indication: Ventricular Arrhythmia

Magnesium Sulfate
    Dosage: i25 mg/kg per dose, ntravenous bolus
    Indication: Ventricular Arrhythmia

Other drugs received by patient: Potassium Chloride; Sodium Hydrogen Carbonate; Albumin (Human); Clcium Gluconate; Vecuronium Bromide; Isoproterenol Hydrochloride; Milrinone



Possible Phenytoin side effects in 64 year old female

Reported by a physician from Japan on 2012-02-13

Patient: 64 year old female

Reactions: Toxicity To Various Agents, Convulsion

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Valproic Acid; Pazufloxacin; Ceftazidime; Clindamycin



Possible Phenytoin side effects in 66 year old male

Reported by a pharmacist from United States on 2012-02-10

Patient: 66 year old male, weighing 84.9 kg (186.8 pounds)

Reactions: Chills, Sedation, Toxicity To Various Agents, Cough, Convulsion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in male

Reported by a physician from United States on 2012-01-31

Patient: male, weighing 113.4 kg (249.4 pounds)

Reactions: Drug Hypersensitivity, Anticonvulsant Drug Level Decreased, Ataxia, Toxicity To Various Agents, Thermal Burn, Suicidal Ideation, Balance Disorder, Depression

Drug(s) suspected as cause:
Dilantin-125
    Dosage: 100 mg,5 per day

Topamax
    Dosage: frequency: 2x/day,
    Indication: Convulsion
    Start date: 2010-01-01

Phenytoin
    Dosage: unk
    Indication: Convulsion

Dilantin-125
    Dosage: 400 mg, unk
    Administration route: Oral
    Indication: Convulsion

Keppra
    Indication: Convulsion
    Start date: 2010-06-06
    End date: 2010-06-16



Possible Phenytoin side effects in 49 year old female

Reported by a physician from United States on 2012-01-25

Patient: 49 year old female

Reactions: Respiratory Arrest, Toxicity To Various Agents, Intentional Drug Misuse, Cardiac Arrest

Adverse event resulted in: death

Drug(s) suspected as cause:
Alprazolam
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Phenytoin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Topiramate
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Acetaminophen and Hydrocodone Bitartrate
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01



Possible Phenytoin side effects in 73 year old female

Reported by a physician from United States on 2012-01-17

Patient: 73 year old female

Reactions: Intentional Drug Misuse, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Omeprazole
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Sertraline Hydrochloride
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Hydroxyzine
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Antihyperlipidemic
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Gabapentin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Phenytoin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Metoprolol Tartrate
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01



Possible Phenytoin side effects in 73 year old female

Reported by a physician from United States on 2012-01-17

Patient: 73 year old female

Reactions: Intentional Drug Misuse, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Hydroxyzine
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Phenytoin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Omeprazole
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Antihyperlipidemic
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Metoprolol Tartrate
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Gabapentin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Sertraline Hydrochloride
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01



Possible Phenytoin side effects in 52 year old male

Reported by a physician from United States on 2012-01-17

Patient: 52 year old male

Reactions: Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Levetiracetam
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Phenytoin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Barbiturate (Barbiturate)
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01



Possible Phenytoin side effects in 58 year old male

Reported by a physician from United States on 2012-01-17

Patient: 58 year old male

Reactions: Completed Suicide, Self Injurious Behaviour, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Atenolol
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Phenytoin
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01

Amlodipine
    Indication: Product Used FOR Unknown Indication
    End date: 2010-01-01



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