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Piperacillin and Tazobactam (Piperacillin / Tazobactam) - Cytolytic Hepatitis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Cytolytic Hepatitis (18)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Piperacillin and Tazobactam (Piperacillin / Tazobactam) where reactions include cytolytic hepatitis. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Piperacillin and Tazobactam side effects in 16 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-26

Patient: 16 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zithromax
    Dosage: 250 mg, 1x/day, from d-2 to the end of treatment
    Administration route: Oral
    Start date: 2012-03-29
    End date: 2012-04-09

Zithromax
    Dosage: 500 mg, 1x/day, d-1
    Administration route: Oral
    Indication: Lung Disorder
    Start date: 2012-03-28
    End date: 2012-03-28

Piperacillin and Tazobactam
    Dosage: 4 g, 3x/day
    Indication: Lung Disorder
    Start date: 2012-04-01
    End date: 2012-04-09

Other drugs received by patient: Rocephin



Possible Piperacillin and Tazobactam side effects in 16 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-08

Patient: 16 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: 4 g, 3x/day
    Indication: Lung Disorder
    Start date: 2012-04-01
    End date: 2012-04-09

Zithromax
    Dosage: 500 mg, 1x/day
    Administration route: Oral
    Indication: Lung Disorder
    Start date: 2012-03-28
    End date: 2012-03-28

Zithromax
    Dosage: 250 mg, 1x/day
    Administration route: Oral
    Start date: 2012-03-29
    End date: 2012-04-09

Other drugs received by patient: Rocephin



Possible Piperacillin and Tazobactam side effects in 24 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-16

Patient: 24 year old male

Reactions: Citrobacter Infection, Anti Factor V Antibody Positive, Pulmonary Alveolar Haemorrhage, Shock Haemorrhagic, Cytolytic Hepatitis, Coagulation Factor V Level Decreased, Cardiogenic Shock, Haemothorax, Klebsiella Infection, Renal Failure, Enterococcal Sepsis, Lung Disorder, Cervix Haematoma Uterine, Shock, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Amoxicillin
    Dosage: intravenous
    Start date: 2012-02-19
    End date: 2012-02-29

Imipenem and Cilastatin
    Dosage: intravenous
    Start date: 2012-03-06
    End date: 2012-03-09

Piperacillin and Tazobactam
    Dosage: intravenous
    Start date: 2012-03-06
    End date: 2012-03-08

Tachosil
    Dosage: 3 sponges in 2 days
    Indication: Haemorrhage
    Start date: 2012-03-09
    End date: 2012-03-10

Gentamicin
    Dosage: intravenous
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-02-20
    End date: 2012-02-29

Cefotaxime
    Dosage: intravenous
    Start date: 2012-03-08
    End date: 2012-03-12



Possible Piperacillin and Tazobactam side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-30

Patient: 53 year old male

Reactions: Cytolytic Hepatitis, Cholestasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: 4 g/day
    Indication: Lung Disorder
    Start date: 2012-01-05
    End date: 2012-01-12

Lamictal
    Dosage: 25 mg/day
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-12-27
    End date: 2012-01-09

Other drugs received by patient: Keppra



Possible Piperacillin and Tazobactam side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-19

Patient: male

Reactions: Cytolytic Hepatitis, Cholestasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: 4 g/day
    Indication: Lung Disorder
    Start date: 2012-01-05
    End date: 2012-01-12

Lamictal
    Dosage: 25 mg/day
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-12-27
    End date: 2012-01-09

Other drugs received by patient: Keppra



Possible Piperacillin and Tazobactam side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-12

Patient: 53 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamictal
    Dosage: 25 mg/day
    Administration route: Oral
    Indication: Convulsion
    Start date: 2011-12-27
    End date: 2012-01-09

Piperacillin and Tazobactam
    Dosage: 4 g/day
    Indication: Lung Disorder
    Start date: 2012-01-05
    End date: 2012-01-12

Other drugs received by patient: Keppra



Possible Piperacillin and Tazobactam side effects in 85 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-12

Patient: 85 year old female

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tegretol
    Dosage: unk
    Start date: 2012-01-05
    End date: 2012-01-25

Piperacillin and Tazobactam
    Dosage: unk
    Indication: Pneumonia Aspiration
    Start date: 2012-01-23
    End date: 2012-02-01

Ciprofloxacin
    Dosage: unk
    Indication: Pneumonia Aspiration
    Start date: 2012-01-23
    End date: 2012-01-25

Other drugs received by patient: Atorvastatin; Levofloxacin; Augmentin '125'



Possible Piperacillin and Tazobactam side effects in 85 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-05

Patient: 85 year old female

Reactions: Cytolytic Hepatitis, Cholestasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ciprofloxacin
    Dosage: unk
    Start date: 2012-01-23
    End date: 2012-01-25

Tegretol
    Dosage: unk
    Start date: 2012-01-05
    End date: 2012-01-25

Piperacillin and Tazobactam
    Dosage: unk
    Start date: 2012-01-23
    End date: 2012-02-01

Other drugs received by patient: Digoxin; Polyethylene Glycol; Amlodipine; Lamictal; Potassium Chloride; Procoralan; Pantoprazole



Possible Piperacillin and Tazobactam side effects in 45 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-23

Patient: 45 year old male

Reactions: Cytolytic Hepatitis, Cholestasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: unk
    Start date: 2011-11-16
    End date: 2011-11-25

Meropenem
    Dosage: unk
    Start date: 2011-11-30

Other drugs received by patient: Diamox SRC; Vancomycin; Midazolam HCL; Lovenox; Lasix; Lasix; Lasix; Ticarcillin; Tracrium; Humalog; Diamox SRC; Gentamicin; Sufenta Preservative Free; Tracrium; Diamox SRC; Diamox SRC; Amikacin



Possible Piperacillin and Tazobactam side effects in 45 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-22

Patient: 45 year old female

Reactions: Lymphadenopathy, Cytolytic Hepatitis, Pancytopenia, Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms, Dermatitis Exfoliative, Eosinophilia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Gentamicin Sulfate
    Indication: Sepsis
    Start date: 2011-07-25
    End date: 2011-08-04

Oxycodone HCL
    Administration route: Oral
    Start date: 2011-07-26

Levofloxacin
    Start date: 2011-07-14
    End date: 2011-07-22

Lovenox
    Start date: 2011-07-26
    End date: 2011-08-08

Targocid
    Start date: 2011-07-25
    End date: 2011-08-03

Piperacillin and Tazobactam
    Start date: 2011-07-31
    End date: 2011-08-12

Other drugs received by patient: Hydroxyzine



Possible Piperacillin and Tazobactam side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-14

Patient: female

Reactions: Hepatic Function Abnormal, Diarrhoea, Haemorrhage, Cytolytic Hepatitis, Acute Respiratory Distress Syndrome, Pancytopenia, Septic Shock

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Indication: Pyrexia
    Start date: 2011-08-25
    End date: 2011-09-04

Ganciclovir Sodium
    Start date: 2011-08-30
    End date: 2011-09-16

Amikacin
    Indication: Pyrexia
    Start date: 2011-08-25
    End date: 2011-08-28

Tienam
    Start date: 2011-10-02

Foscavir
    Indication: Cytomegalovirus Infection
    Start date: 2011-09-03
    End date: 2011-09-09

Vancomycin HCL
    Indication: Pyrexia
    Start date: 2011-09-09
    End date: 2011-09-13

Tienam
    Indication: Pyrexia
    Start date: 2011-09-09
    End date: 2011-09-18

Amikacin
    Start date: 2011-09-09

Foscavir
    Start date: 2011-09-30

Piperacillin and Tazobactam
    End date: 2011-10-02

Ganciclovir Sodium
    Indication: Cytomegalovirus Infection

Other drugs received by patient: Cancidas; Cancidas; Imuran



Possible Piperacillin and Tazobactam side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-11

Patient: 56 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clarithromycin
    Start date: 2008-06-29
    End date: 2008-07-14

Acetaminophen
    Start date: 2008-06-29
    End date: 2008-07-17

Desloratadine
    Administration route: Oral
    Start date: 2008-07-09

Venofer
    Start date: 2008-07-11

Acetaminophen
    Administration route: Oral
    Start date: 2008-07-18

Cipro
    Start date: 2008-07-02
    End date: 2008-07-04

TPN
    Start date: 2008-07-11

Moxifloxacin HCL
    Start date: 2008-06-29
    End date: 2008-07-02

Levofloxacin
    Start date: 2008-07-03

Primaxin
    Indication: Pseudomonas Infection
    Start date: 2008-07-18

Piperacillin and Tazobactam
    Start date: 2008-07-07
    End date: 2008-07-11

Zyvox
    Administration route: Oral
    Start date: 2008-07-14

Omeprazole
    Administration route: Oral
    Start date: 2008-07-17

Lovenox
    Start date: 2008-07-05

Rocephin
    Start date: 2008-06-29
    End date: 2008-07-02

Other drugs received by patient: Fluconazole; Innohep; Solu-Medrol; Atarax (Alprazolam); Sucralfate



Possible Piperacillin and Tazobactam side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-08

Patient: male

Reactions: Hepatocellular Injury, Hairy Cell Leukaemia, Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: unk
    Start date: 2008-07-07
    End date: 2008-07-11

Ciprofloxacin
    Dosage: 3 df per day
    Start date: 2008-07-02
    End date: 2008-07-04

Nutriflex ^braun^

Omeprazole
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-17

Zyvox
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-14

Moxifloxacin HCL
    Dosage: 1 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Venofer
    Dosage: 3 df per day
    Start date: 2008-07-11

Tienam
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-18

Clarithromycin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-14

Paracetamol
    Dosage: 4 df per day
    Start date: 2008-06-29
    End date: 2008-07-17

Rocephin
    Dosage: 2 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Levofloxacin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-07-03

Lovenox
    Dosage: 1 df per day
    Start date: 2008-07-05

Desloratadine
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-09

Acetaminophen
    Dosage: 4 df per day
    Administration route: Oral
    Start date: 2008-07-18

Other drugs received by patient: Atarax; Sucralfate; Innohep; Solu-Medrol; Fluconazole



Possible Piperacillin and Tazobactam side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-04

Patient: 56 year old male

Reactions: Blood Bilirubin Increased, Gamma-Glutamyltransferase Increased, Cytolytic Hepatitis, Condition Aggravated, Rash Pruritic

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clarithromycin
    Dosage: 1 g total daily
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-14

Lovenox
    Dosage: 1 dosage form total daily
    Start date: 2008-07-05

Piperacillin and Tazobactam
    Dosage: 16 g total daily
    Indication: Lung Infection
    Start date: 2008-07-07
    End date: 2008-07-11

Ciprofloxacin
    Dosage: 3 dosage forms total daily
    Indication: Pneumonia Legionella
    Start date: 2008-07-02
    End date: 2008-07-04

Tienam
    Dosage: 3 dosages form
    Administration route: Oral
    Indication: Lung Infection
    Start date: 2008-07-18

Rocephin
    Dosage: 4 g; frequency unspecified
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-02

Moxifloxacin HCL
    Dosage: 400 mg, 1x/day
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-02

Levofloxacin
    Dosage: 10 mg total daily
    Indication: Pneumonia Legionella
    Start date: 2008-07-03

Venofer
    Dosage: 300 mg total daily
    Start date: 2008-07-11

Zyvox
    Dosage: 3 dosages form total daily
    Administration route: Oral
    Start date: 2008-07-14

Desloratadine
    Dosage: 1.0 df, 1x/day
    Administration route: Oral
    Start date: 2008-07-09

Nutriflex ^vifor^
    Dosage: unknown

Acetaminophen
    Dosage: 4 dosages form total daily
    Administration route: Oral
    Start date: 2008-07-18

Acetaminophen
    Dosage: 40 mg total daily
    Start date: 2008-06-29
    End date: 2008-07-17

Omeprazole
    Dosage: 1 df, 1x/day
    Administration route: Oral
    Start date: 2008-07-17

Other drugs received by patient: Sucralfate



Possible Piperacillin and Tazobactam side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-03

Patient: 56 year old male

Reactions: Superinfection, Pseudomonas Infection, Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Desloratadine
    Dosage: 1 df; qd; po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-07-09

Clarithromycin
    Dosage: 2 df; qd; iv
    Indication: Legionella Infection
    Start date: 2008-07-01
    End date: 2008-07-14

Acetaminophen
    Dosage: 4 df; qd; iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-06-29
    End date: 2008-07-17

Levofloxacin
    Dosage: 2 df; qd; iv
    Indication: Legionella Infection
    Start date: 2008-07-01

Nutri-Flex (Glucosamine Fulfate, Hydrolyzed Gelatin, Methyl Sulfonyl M
    Indication: Product Used FOR Unknown Indication

Zyvox
    Dosage: 3 df; qd; po
    Administration route: Oral
    Indication: Staphylococcal Infection
    Start date: 2008-07-14

Acetaminophen
    Dosage: 4 df; qd; po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-07-18

Rocephin
    Dosage: 2 df; qd; iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-06-29
    End date: 2008-07-02

Moxifloxacin Hydrochloride
    Dosage: 1 df; qd; iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-06-26
    End date: 2008-07-02

Omeprazole
    Dosage: 1 df; qd; po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-07-17

Ciprofloxacin
    Dosage: 3 df; qd; iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-06-29
    End date: 2008-07-04

Piperacillin and Tazobactam
    Dosage: 3 df; qd; iv
    Indication: Superinfection
    Start date: 2008-07-07
    End date: 2008-07-11

Venofer
    Dosage: 3 df; qd; iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-07-11

Primaxin
    Dosage: 3 df; qd; po
    Administration route: Oral
    Indication: Infection
    Start date: 2008-07-18

Lovenox
    Dosage: 2 df; qd; sc
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-07-05



Possible Piperacillin and Tazobactam side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-03

Patient: 56 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Acetaminophen
    Dosage: 4 df per day
    Start date: 2008-06-29
    End date: 2008-07-17

Venofer
    Dosage: 3 df per day
    Start date: 2008-07-11

Nutriflex ^braun^

Moxifloxacin HCL
    Dosage: 1 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Ciprofloxacin
    Dosage: 3 df per day
    Start date: 2008-07-02
    End date: 2008-07-04

Acetaminophen
    Dosage: 4 df per day
    Administration route: Oral
    Start date: 2008-07-18

Clarithromycin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-14

Zyvox
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-14

Omeprazole
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-17

Lovenox
    Dosage: 1 df per day
    Start date: 2008-07-05

Piperacillin and Tazobactam
    Dosage: unk
    Start date: 2008-07-07
    End date: 2008-07-11

Rocephin
    Dosage: 2 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Levofloxacin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-07-03

Desloratadine
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-09

Tienam
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-18

Other drugs received by patient: Innohep; Atarax; Fluconazole; Solu-Medrol; Sucralfate



Possible Piperacillin and Tazobactam side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-24

Patient: 56 year old male

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Acetaminophen
    Dosage: 4 df per day
    Start date: 2008-06-29
    End date: 2008-07-17

Ciprofloxacin
    Dosage: 3 df per day
    Start date: 2008-07-02
    End date: 2008-07-04

Levofloxacin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-07-03

Venofer
    Dosage: 3 df per day
    Start date: 2008-07-11

Acetaminophen
    Dosage: 4 df per day
    Administration route: Oral
    Start date: 2008-07-18

Moxifloxacin HCL
    Dosage: 1 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Nutriflex ^braun^

Zyvox
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-14

Desloratadine
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-09

Piperacillin and Tazobactam
    Dosage: unk
    Start date: 2008-07-07
    End date: 2008-07-11

Omeprazole
    Dosage: 1 df per day
    Administration route: Oral
    Start date: 2008-07-17

Tienam
    Dosage: 3 df per day
    Administration route: Oral
    Indication: Prophylaxis
    Start date: 2008-07-18

Rocephin
    Dosage: 2 df per day
    Start date: 2008-06-29
    End date: 2008-07-02

Lovenox
    Dosage: 1 df per day
    Start date: 2008-07-05

Clarithromycin
    Dosage: 2 df per day
    Indication: Pneumonia Legionella
    Start date: 2008-06-29
    End date: 2008-07-14

Other drugs received by patient: Solu-Medrol; Fluconazole; Innohep; Sucralfate; Atarax



Possible Piperacillin and Tazobactam side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-10

Patient: 64 year old female

Reactions: Cytolytic Hepatitis, Pyrexia, Eosinophilia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Piperacillin and Tazobactam
    Dosage: unk
    Indication: Inflammation
    Start date: 2011-09-08
    End date: 2011-09-09

Piperacillin and Tazobactam
    Dosage: unk
    Indication: Pyrexia
    Start date: 2011-08-13
    End date: 2011-08-15

Other drugs received by patient: Ciprofloxacin; Enalapril Maleate; Ciprofloxacin; Prednisone; Rapamune; Diamicron; Hyperium; Mycophenolate Mofetil (Cellcept); Levothyroxine Sodium; Atorvastatin Calcium; Prazosin HCL; Neoral; Ferrous Sulfate TAB; Amlodipine / Valsartan; Vitamin D

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