Index of reports
> Cases with Hepatic Encephalopathy (13)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Pyrazinamide where reactions include hepatic encephalopathy. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Pyrazinamide side effects in 20 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-18
Patient: 20 year old male
Reactions: Jaundice, Hepatic Encephalopathy, Acute Hepatic Failure, Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient: Azathioprine; Rifampicin; Isoniazid; Cyclosporine; Streptomycin; Prednisolone; Ethambutol Hydrochloride
Possible Pyrazinamide side effects in 25 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-18
Patient: 25 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Acute Hepatic Failure, Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient: Rifampicin; Azathioprine; Prednisolone; Isoniazid; Cyclosporine
Possible Pyrazinamide side effects in 20 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-18
Patient: 20 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Sepsis, Shock Haemorrhagic, Acute Hepatic Failure, Hepatitis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient: Rifampicin; Ethambutol Hydrochloride; Prednisolone; Tacrolimus; Ofloxacin; Isoniazid
Possible Pyrazinamide side effects in 40 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-18
Patient: 40 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Acute Respiratory Distress Syndrome, Acute Hepatic Failure, Hepatitis, Septic Shock, Blood Creatinine Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient: Rifampicin; Isoniazid
Possible Pyrazinamide side effects in 8 month old female
Reported by a physician from Canada on 2012-07-12
Patient: 8 month old female
Reactions: Hepatic Encephalopathy, Immune Reconstitution Syndrome, Hepatotoxicity, Hepatitis B Surface Antibody Positive, Acute Hepatic Failure, Vaccination Failure, Hepatic Cirrhosis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient: Isoniazid; Rifampicin; Cotrimoxale Prophylaxis; Ethambutol Hydrochloride
Possible Pyrazinamide side effects in 20 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 20 year old male
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Acute Hepatic Failure, Liver Transplant Rejection, Drug Interaction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Azathioprine
Indication: Immunosuppression
Cyclosporine
Indication: Immunosuppression
Prednisolone
Indication: Immunosuppression
Rifampicin
Indication: Pulmonary Tuberculosis
Rifampicin
Other drugs received by patient: Ethambutol Hydrochloride; Isoniazid; Rifampicin; Streptomycin; Streptomycin; Ethambutol Hydrochloride
Possible Pyrazinamide side effects in 25 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 25 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Drug Interaction, Acute Hepatic Failure, Liver Transplant Rejection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Azathioprine
Indication: Immunosuppression
Cyclosporine
Indication: Immunosuppression
Prednisolone
Indication: Immunosuppression
Rifampicin
Rifampicin
Indication: Pulmonary Tuberculosis
Other drugs received by patient: Ofloxacin; Ofloxacin; Rifampicin; Ethambutol Hydrochloride; Isoniazid
Possible Pyrazinamide side effects in 20 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 20 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Liver Transplant Rejection, Drug Interaction, Acute Hepatic Failure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Prednisolone
Indication: Immunosuppression
Rifampicin
Rifampicin
Rifampicin
Dosage: half of the dose every two days
Indication: Pulmonary Tuberculosis
Tacrolimus
Indication: Immunosuppression
Other drugs received by patient: Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ofloxacin; Isoniazid; Ethambutol Hydrochloride; Rifampicin; Ofloxacin
Possible Pyrazinamide side effects in 45 year old female
Reported by a health professional (non-physician/pharmacist) from India on 2012-05-09
Patient: 45 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Acute Hepatic Failure, Depressed Level of Consciousness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ethambutol Hydrochloride
Indication: Tuberculosis
Isoniazid
Indication: Tuberculosis
Pyrazinamide
Rifampicin
Indication: Tuberculosis
Possible Pyrazinamide side effects in 35 year old female
Reported by a consumer/non-health professional from France on 2012-03-14
Patient: 35 year old female
Reactions: Hepatic Encephalopathy, Hepatitis Fulminant
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Myambutol
Administration route: Oral
Indication: Pulmonary Tuberculosis
Start date: 2011-10-14
End date: 2011-11-28
Pyrazinamide
Administration route: Oral
Indication: Pulmonary Tuberculosis
Start date: 2011-10-14
End date: 2011-11-28
Rifabutin
Administration route: Oral
Indication: Pulmonary Tuberculosis
Start date: 2011-10-14
End date: 2011-11-28
Rimifon
Dosage: 150 mg
Administration route: Oral
Indication: Pulmonary Tuberculosis
Start date: 2011-10-14
End date: 2011-11-28
Sustiva
Indication: HIV Infection
Other drugs received by patient: Truvada; Atarax; Acetaminophen
Possible Pyrazinamide side effects in 19 year old female
Reported by a health professional (non-physician/pharmacist) from Turkey on 2011-11-10
Patient: 19 year old female
Reactions: Hepatic Encephalopathy, Heart Rate Increased, Acute Hepatic Failure, Loss of Consciousness
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Ethambutol Hydrochloride
Dosage: 1500 mg/day
Indication: Tuberculosis
Isoniazid
Dosage: 300 mg/day
Indication: Tuberculosis
Pyrazinamide
Dosage: 1500 mg/day
Indication: Tuberculosis
Rifampicin
Dosage: 600 mg/day
Indication: Tuberculosis
Possible Pyrazinamide side effects in 8 month old female
Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-20
Patient: 8 month old female
Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B
Adverse event resulted in: death
Drug(s) suspected as cause:
Amikacin
Dosage: usp
Indication: Tuberculosis
Ciprofloxacin
Indication: Tuberculosis
Cotrim
Indication: Tuberculosis
Ethambutol Hydrochloride
Indication: Tuberculosis
Hepatitis B Vaccine
Dosage: received at 6, 10 and 14 weeks of life
Indication: Product Used FOR Unknown Indication
Isoniazid
Indication: Tuberculosis
Lamivudine
Indication: HIV Infection
Lamivudine
Lopinavir / Ritonavir
Lopinavir / Ritonavir
Indication: HIV Infection
Pyrazinamide
Indication: Tuberculosis
Rifampin
Indication: Tuberculosis
Ritonavir
Indication: HIV Infection
Ritonavir
Tice BCG
Dosage: liquid intradermal
Indication: Product Used FOR Unknown Indication
Zidovudine
Zidovudine
Indication: HIV Infection
Possible Pyrazinamide side effects in 8 month old female
Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-18
Patient: 8 month old female
Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B
Adverse event resulted in: death
Drug(s) suspected as cause:
Amikacin
Dosage: usp
Indication: Tuberculosis
Ciprofloxacin
Indication: Tuberculosis
Cotrim
Indication: Tuberculosis
Ethambutol Hydrochloride
Indication: Tuberculosis
Hepatitis B Vaccine
Dosage: received at 6, 10 and 14 weeks of life
Indication: Product Used FOR Unknown Indication
Isoniazid
Indication: Tuberculosis
Kaletra
Kaletra
Indication: HIV Infection
Lamivudine
Lamivudine
Indication: HIV Infection
Norvir
Indication: HIV Infection
Norvir
Pyrazinamide
Indication: Tuberculosis
Rifampin
Indication: Tuberculosis
Tice BCG
Dosage: liquid intradermal
Indication: Product Used FOR Unknown Indication
Zidovudine
Indication: HIV Infection
Zidovudine
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