This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Vandetanib and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (237)
Death (10)
Life Threatening Events (19)
Disability (2)
Reports by Reaction Type
Diarrhoea (49),
Rash (27),
Fatigue (25),
Nausea (23),
Acne (22),
Electrocardiogram QT Prolonged (20),
Blood Pressure Increased (18),
Dizziness (15),
Dyspnoea (13),
Oral Pain (13),
Decreased Appetite (12),
Renal Failure (12)
Below are a few examples of reports where side effects / adverse reactions may be related to Vandetanib. For a complete list or a specific selection of reports, please use the links above.
Possible Vandetanib side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male, weighing 70.0 kg (154.0 pounds)
Reactions: Pulmonary Embolism, Lower Respiratory Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Gemcitabine Hydrochloride
Indication: Pancreatic Carcinoma Metastatic
Start date: 2012-06-13
End date: 2012-07-25
Vandetanib
Administration route: Oral
Indication: Pancreatic Carcinoma Metastatic
Start date: 2012-06-16
End date: 2012-08-07
Other drugs received by patient: Perindopril; Metformin HCL; Zopiclone; Docusate Sodium; Omeprazole
Possible Vandetanib side effects in 759 month old male
Reported by a physician from France on 2012-08-09
Patient: 759 month old male, weighing 89.0 kg (195.8 pounds)
Reactions: Dysgeusia, Diarrhoea, Folliculitis, Optic Ischaemic Neuropathy, Hypertension
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Other drugs received by patient: Rythmol; Previscan
Possible Vandetanib side effects in 56 year old male
Reported by a physician from Spain on 2012-08-06
Patient: 56 year old male, weighing 56.0 kg (123.2 pounds)
Reactions: Renal Failure, Hypoparathyroidism, Hypocalcaemia, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Other drugs received by patient: Duragesic-100; Levothyroxine Sodium; Omeprazole
Possible Vandetanib side effects in male
Reported by a physician from United Kingdom on 2012-08-06
Patient: male, weighing 60.4 kg (132.9 pounds)
Reactions: Lower Respiratory Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Adenocarcinoma Pancreas
Start date: 2012-07-13
End date: 2012-07-15
Gemcitabine Hydrochloride
Indication: Adenocarcinoma Pancreas
Start date: 2012-07-13
End date: 2012-07-15
Possible Vandetanib side effects in 55 year old male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: 55 year old male
Reactions: Speech Disorder, Neoplasm Malignant
Drug(s) suspected as cause:
Vandetanib
Possible Vandetanib side effects in 75 year old male
Reported by a physician from United Kingdom on 2012-07-23
Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)
Reactions: Hyperglycaemia, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Pancreatic Carcinoma
Start date: 2012-06-05
End date: 2012-06-19
Gemcitabine
Indication: Pancreatic Carcinoma
Start date: 2012-05-08
Other drugs received by patient: Pravastatin Sodium; Felodipine; Oramorph SR; Paroxetine; Metformin Hydrochloride; Gliclazide
Possible Vandetanib side effects in 75 year old male
Reported by a physician from United Kingdom on 2012-07-23
Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)
Reactions: Hyperglycaemia, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Gemcitabine
Indication: Pancreatic Carcinoma
Start date: 2012-05-08
Vandetanib
Administration route: Oral
Indication: Pancreatic Carcinoma
Start date: 2012-06-05
End date: 2012-06-19
Other drugs received by patient: Gliclazide; Oramorph SR; Paroxetine; Metformin Hydrochloride; Pravastatin Sodium; Felodipine
Possible Vandetanib side effects in 56 year old male
Reported by a physician from Spain on 2012-07-19
Patient: 56 year old male
Reactions: Renal Failure, Hypoparathyroidism, Hypocalcaemia, Adverse Event
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Possible Vandetanib side effects in female
Reported by a physician from Poland on 2012-07-11
Patient: female
Reactions: Renal Failure, Hypercalcaemia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Pamidronate Disodium
Dosage: as required
Indication: Metastases To Spine
Start date: 2012-04-01
End date: 2012-06-12
Vandetanib
Administration route: Oral
Start date: 2011-09-03
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-08-16
Other drugs received by patient: Euthyrox N; Calperos; Magne B6; Pantoprazole; Euthyrox N; Loperamide; Alfadiol; Pramolan; Calperos; Potassium Chloride
Possible Vandetanib side effects in 75 year old male
Reported by a physician from United Kingdom on 2012-07-09
Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)
Reactions: Hyperglycaemia, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Gemcitabine
Indication: Pancreatic Carcinoma
Start date: 2012-05-08
Vandetanib
Administration route: Oral
Indication: Pancreatic Carcinoma
Start date: 2012-06-05
End date: 2012-06-19
Other drugs received by patient: Metformin HCL; Pravastatin Sodium; Gliclazide; Felodipine; Oramorph SR; Paroxetine
Possible Vandetanib side effects in male
Reported by a physician from France on 2012-07-02
Patient: male
Reactions: Corneal Dystrophy
Drug(s) suspected as cause:
Vandetanib
Other drugs received by patient: Primperan TAB; Levothyroxine Sodium; Irbesartan and Hydrochlorothiazide; Imodium; UN-Alfa; Xanax
Possible Vandetanib side effects in female
Reported by a physician from Poland on 2012-06-29
Patient: female
Reactions: Renal Failure, Hypercalcaemia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Pamidronate Disodium
Dosage: as required
Indication: Metastases To Spine
Start date: 2012-04-01
End date: 2012-06-12
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-08-16
Vandetanib
Administration route: Oral
Start date: 2011-09-03
Other drugs received by patient: Pramolan; Calperos; Loperamide; Euthyrox N; Pantoprazole; Alfadiol; Magne B6; Euthyrox N; Calperos; Potassium Chloride
Possible Vandetanib side effects in female
Reported by a physician from Poland on 2012-06-29
Patient: female
Reactions: Renal Failure, Hypercalcaemia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-08-16
Pamidronate Disodium
Dosage: as required
Indication: Metastases To Spine
Start date: 2012-04-01
End date: 2012-06-12
Vandetanib
Administration route: Oral
Start date: 2011-09-03
Other drugs received by patient: Loperamide; Pantoprazole; Magne B6; Calperos; Potassium Chloride; Euthyrox N; Calperos; Alfadiol; Euthyrox N; Pramolan
Possible Vandetanib side effects in female
Reported by a pharmacist from France on 2012-06-28
Patient: female, weighing 46.0 kg (101.2 pounds)
Reactions: Visual Acuity Reduced, Corneal Deposits
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Start date: 2007-11-01
End date: 2010-11-01
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2007-02-28
End date: 2007-11-01
Vandetanib
Administration route: Oral
Start date: 2010-12-14
End date: 2011-06-20
Vandetanib
Administration route: Oral
End date: 2012-05-16
Other drugs received by patient: Pravastatin; Levothyroxine Sodium; Potassium Chloride; UN-Alpha; Nicardipine Hydrochloride
Possible Vandetanib side effects in female
Reported by a physician from Belgium on 2012-06-26
Patient: female
Reactions: Large Intestine Perforation, Intestinal Obstruction
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-05-21
End date: 2011-05-27
Vandetanib
Administration route: Oral
Start date: 2011-06-16
End date: 2011-06-16
Vandetanib
Dosage: dose reduced
Administration route: Oral
Start date: 2011-06-17
End date: 2011-07-01
Other drugs received by patient: Lorazepam; Zometa; Alpha LEO; Loramet; Polyethylene Glycol; Pantoprazole; Targinact; Laxoberon; Calcium; Elthyrone; Litican; Oxycodone HCL; Imodium; Closan; Voltaren; Medrol; Redomex; MS Contin
Possible Vandetanib side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-26
Patient:
Reactions: Thrombocytopenia
Drug(s) suspected as cause:
Vandetanib
Dosage: 100-300 mg daily
Administration route: Oral
Indication: Thyroid Cancer
Bortezomib
Dosage: 1-1.3 mg/m2
Indication: Thyroid Cancer
Possible Vandetanib side effects in male
Reported by a physician from Bulgaria on 2012-06-19
Patient: male
Reactions: Photosensitivity Reaction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2012-01-13
End date: 2012-02-20
Vandetanib
Administration route: Oral
Start date: 2012-02-26
End date: 2012-04-27
Other drugs received by patient: Levothyroxine Sodium
Possible Vandetanib side effects in female
Reported by a physician from Belgium on 2012-06-18
Patient: female
Reactions: Large Intestine Perforation, Intestinal Obstruction
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-05-21
End date: 2011-05-27
Vandetanib
Administration route: Oral
Start date: 2011-06-16
End date: 2011-06-16
Vandetanib
Dosage: dose reduced
Administration route: Oral
Start date: 2011-06-17
End date: 2011-07-01
Other drugs received by patient: Calcium; Alpha LEO; MS Contin; Closan; Laxoberon; Litican; Zometa; Voltaren; Redomex; Oxynorm; Imodium; Elthyrone; Pantoprazole; Targinact; Polyethylene Glycol; Medrol; Loramet; Lorazepam
Possible Vandetanib side effects in 72 year old female
Reported by a physician from United Kingdom on 2012-06-18
Patient: 72 year old female
Reactions: Haematocrit Increased
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-09-06
End date: 2011-09-19
Vandetanib
Administration route: Oral
Start date: 2011-10-04
End date: 2012-04-12
Other drugs received by patient: Calcichew D3; Amlodipine; Loperamide; Amlodipine; Levothyroxine Sodium; Aldonic Acid; Acetaminophen; Vitamin B Complex CAP
Possible Vandetanib side effects in female
Reported by a pharmacist from France on 2012-06-14
Patient: female, weighing 46.0 kg (101.2 pounds)
Reactions: Visual Acuity Reduced, Corneal Deposits
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2007-02-28
End date: 2007-11-01
Vandetanib
Administration route: Oral
Start date: 2007-11-01
End date: 2010-11-01
Vandetanib
Administration route: Oral
Start date: 2010-12-14
End date: 2011-06-20
Vandetanib
Administration route: Oral
End date: 2012-05-16
Other drugs received by patient: Nicardipine Hydrochloride; Levothyroxine Sodium; Pravastatin; UN-Alpha; Potassium Chloride
Possible Vandetanib side effects in 49 year old male
Reported by a physician from United States on 2012-05-29
Patient: 49 year old male, weighing 73.2 kg (161.0 pounds)
Reactions: ECG Signs of Myocardial Ischaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Midazolam
Administration route: Oral
Start date: 2012-05-02
End date: 2012-05-02
Vandetanib
Administration route: Oral
Start date: 2012-05-17
End date: 2012-05-17
Possible Vandetanib side effects in 49 year old male
Reported by a physician from United States on 2012-05-29
Patient: 49 year old male, weighing 73.2 kg (161.0 pounds)
Reactions: ECG Signs of Myocardial Ischaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Start date: 2012-05-17
End date: 2012-05-17
Midazolam
Administration route: Oral
Start date: 2012-05-02
End date: 2012-05-02
Possible Vandetanib side effects in 76 year old female
Reported by a physician from United Kingdom on 2012-05-25
Patient: 76 year old female, weighing 45.6 kg (100.3 pounds)
Reactions: Acute Coronary Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Pancreatic Carcinoma
Start date: 2012-04-30
End date: 2012-05-08
Gemcitabine
Indication: Pancreatic Carcinoma
Start date: 2012-04-30
End date: 2012-04-30
Other drugs received by patient: Spiriva; Fluticasone Propionate / Salmeterol; Oramorph SR; Senna-Mint WAF; Lansoprazole; Buprenorphine; Albuterol; Aspirin
Possible Vandetanib side effects in female
Reported by a pharmacist from France on 2012-05-25
Patient: female, weighing 49.0 kg (107.8 pounds)
Reactions: Visual Acuity Reduced, Corneal Deposits
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Start date: 2010-12-14
End date: 2012-05-16
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2007-02-28
End date: 2007-11-01
Vandetanib
Administration route: Oral
Start date: 2007-11-01
End date: 2010-11-01
Possible Vandetanib side effects in male
Reported by a physician from Bulgaria on 2012-05-22
Patient: male
Reactions: Dermatitis Allergic
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2012-01-13
End date: 2012-02-20
Vandetanib
Administration route: Oral
Start date: 2012-02-26
End date: 2012-04-27
Other drugs received by patient: Levothyroxine Sodium
Possible Vandetanib side effects in male
Reported by a physician from Bulgaria on 2012-05-22
Patient: male
Reactions: Dermatitis Allergic
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Start date: 2012-02-26
End date: 2012-04-27
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2012-01-13
End date: 2012-02-20
Other drugs received by patient: Levothyroxine Sodium
Possible Vandetanib side effects in male
Reported by a physician from United Kingdom on 2012-05-21
Patient: male
Reactions: Abscess Limb
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Vandetanib
Administration route: Oral
Start date: 2011-12-19
Vandetanib
Administration route: Oral
Indication: Thyroid Cancer
Start date: 2011-07-22
End date: 2011-09-26
Vandetanib
Administration route: Oral
Start date: 2011-10-28
End date: 2011-11-07
Vandetanib
Administration route: Oral
Start date: 2011-10-03
End date: 2011-10-10
Other drugs received by patient: Plavix FC; Dothiepin Hydrochloride; Levothyroxine Sodium; Simvastatin; Dothiepin Hydrochloride; Diazepam; Omeprazole; Lactulose; Mucodyne; Bisoprilol
Possible Vandetanib side effects in 49 year old male
Reported by a consumer/non-health professional from United States on 2012-05-18
Patient: 49 year old male
Reactions: Blood Pressure Increased, Nausea, Musculoskeletal Discomfort, Dizziness, Hyperhidrosis
Drug(s) suspected as cause:
Vandetanib
Possible Vandetanib side effects in 40 year old female
Reported by a individual with unspecified qualification from United States on 2012-05-10
Patient: 40 year old female
Reactions: Brain Neoplasm Malignant, Pain, Neoplasm Progression, Blood Calcitonin Increased
Drug(s) suspected as cause:
Vandetanib
Other drugs received by patient: Nexavar; Sutent
Possible Vandetanib side effects in 40 year old female
Reported by a individual with unspecified qualification from United States on 2012-05-09
Patient: 40 year old female
Reactions: Brain Neoplasm Malignant, Hepatic Neoplasm Malignant, Pain, Neoplasm Progression, Blood Calcitonin Increased
Drug(s) suspected as cause:
Vandetanib
Other drugs received by patient: Nexavar; Sutent
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