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Xeloda (Capecitabine) - Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Neutropenia (91)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Xeloda (Capecitabine) where reactions include neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 91   Next >>

Possible Xeloda side effects in 62 year old male

Reported by a physician from Poland on 2012-08-23

Patient: 62 year old male

Reactions: Kwashiorkor, Carcinoembryonic Antigen Increased, Increased Appetite, Nausea, Anaemia, General Physical Health Deterioration, Palmar-Plantar Erythrodysaesthesia Syndrome, Ascites, Apathy, Death, Neutropenia, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Cisplatin
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-12-14

Xeloda
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-12-14

Other drugs received by patient: Diaprel MR



Possible Xeloda side effects in female

Reported by a physician from Switzerland on 2012-08-22

Patient: female, weighing 62.0 kg (136.4 pounds)

Reactions: Abdominal Pain, Vomiting, Anaemia, Lymphopenia, Pyrexia, Diarrhoea, Small Intestinal Perforation, Sepsis, Hypoalbuminaemia, Neutropenia, Enterocolitis, Infection

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Herceptin



Possible Xeloda side effects in female

Reported by a consumer/non-health professional from United States on 2012-08-20

Patient: female, weighing 43.6 kg (95.9 pounds)

Reactions: Stomatitis, White Blood Cell Disorder, Electrolyte Imbalance, Neutropenia, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-13

Patient:

Reactions: Abdominal Pain, Blood Bilirubin Increased, Thrombosis, Anal Examination Abnormal, Hypokalaemia, Fatigue, Proteinuria, Abdominal Distension, Decreased Appetite, Nausea, Palmar-Plantar Erythrodysaesthesia Syndrome, Hyponatraemia, Small Intestinal Obstruction, Hypophosphataemia, Diarrhoea, Alopecia, Dehydration, Neutropenia, Hypertension, Vascular Access Complication

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Dosage: given on day 1
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride and Irinotecan Hydrochloride
    Dosage: given on day 1
    Indication: Colorectal Cancer Metastatic

Xeloda
    Dosage: 1000 mg/m2 twice daily for age below 65 years,750 mg/m2 twice daily for age above 65 years
    Administration route: Oral
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from Italy on 2012-08-08

Patient:

Reactions: Stomatitis, Anaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Liver Disorder, Mucosal Inflammation, Fatigue, Diarrhoea, Neutropenia, Thrombocytopenia, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lapatinib
    Indication: Breast Cancer Metastatic

Xeloda
    Indication: Breast Cancer Metastatic



Possible Xeloda side effects in

Reported by a physician from Spain on 2012-08-07

Patient:

Reactions: Abdominal Pain, Dyspnoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Mucosal Inflammation, Death, Fatigue, Diarrhoea, Neutropenia, Hypertension, Asthenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Blinded Sorafenib and Blinded Sorafenib
    Administration route: Oral
    Indication: Breast Cancer

Xeloda
    Dosage: drug was used for 14 days every 21 days.
    Administration route: Oral
    Indication: Breast Cancer



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-06

Patient:

Reactions: Vomiting, Anaemia, Pulmonary Embolism, Febrile Neutropenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Peripheral Sensory Neuropathy, Mucosal Inflammation, Diarrhoea, Proteinuria, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Avastin
    Dosage: fluorouracil based regimen
    Indication: Colorectal Cancer Metastatic

Avastin
    Dosage: capecitabine-based regimen

Fluorouracil
    Dosage: on day 1

Fluorouracil
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride
    Dosage: dose: 150/180 mg/m2 on day 1
    Indication: Colorectal Cancer Metastatic

Leucovorin Calcium
    Dosage: on day 1
    Indication: Colorectal Cancer Metastatic

Oxaliplatin
    Dosage: on day 1
    Indication: Colorectal Cancer Metastatic

Xeloda
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in female

Reported by a physician from Japan on 2012-07-30

Patient: female, weighing 45.0 kg (99.0 pounds)

Reactions: Vomiting, Incontinence, Disseminated Intravascular Coagulation, Platelet Count Decreased, Acute Hepatic Failure, Neutropenia, Altered State of Consciousness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Meropenem
    Dosage: dosage is uncertain.
    Indication: Infection Prophylaxis
    Start date: 2011-10-14
    End date: 2011-10-18

Xeloda
    Administration route: Oral
    Indication: Rectal Cancer
    Start date: 2011-08-29
    End date: 2011-09-11

Xeloda
    Administration route: Oral
    Start date: 2011-09-26
    End date: 2011-10-09

Other drugs received by patient: Aloxi; Dexamethasone Sodium Phosphate; Ganaton; Oxaliplatin; Famotidine; Pydoxal



Possible Xeloda side effects in 80 year old female

Reported by a physician from Lebanon on 2012-07-26

Patient: 80 year old female

Reactions: Skin Exfoliation, Pancytopenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Mucosal Inflammation, Diarrhoea, Skin Discolouration, Neutropenia, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Morocco on 2012-07-24

Patient:

Reactions: Neuropathy Peripheral, Diarrhoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Neutropenia, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Colorectal Cancer

Irinotecan Hydrochloride
    Indication: Colorectal Cancer

Oxaliplatin
    Indication: Colorectal Cancer

Xeloda
    Indication: Colorectal Cancer



Possible Xeloda side effects in male

Reported by a physician from Sweden on 2012-07-23

Patient: male

Reactions: Gastrointestinal Disorder, Metabolic Disorder, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Epirubicin Hydrochloride
    Dosage: last dose prior to sae 23/may/2012, cumulative dose 200 mg
    Indication: Gastric Cancer
    Start date: 2012-05-02

Oxaliplatin
    Dosage: last dose prior to sae 23/may/2012, cumulative dose 500 mg
    Indication: Gastric Cancer
    Start date: 2012-05-02

Xeloda
    Dosage: last dose prior to sae 3/jun/2012, cumulative dose 73600 9units not provided)
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-05-02



Possible Xeloda side effects in female

Reported by a physician from Germany on 2012-07-19

Patient: female

Reactions: Weight Decreased, Pulmonary Embolism, Pyrexia, Hyperhidrosis, Cardiac Disorder, Intestinal Perforation, Dyspepsia, Proteinuria, Epistaxis, Gingival Bleeding, Anaemia, Cardiomyopathy, Neutropenia, Hypersensitivity, Bone Pain, Pain, Chills, Skin Reaction, Abdominal Pain Upper, Polyneuropathy, Myalgia, Fatigue, Oedema, Dizziness, Myocardial Infarction, Nail Toxicity, Thrombocytopenia, Decreased Appetite, Vomiting, Dyspnoea, Nausea, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Cerebrovascular Accident, Dysgeusia, Mucosal Inflammation, Anxiety, Diarrhoea, Impaired Healing, Arthralgia, Hypertension, Asthenia, Leukopenia

Drug(s) suspected as cause:
Avastin
    Indication: Breast Cancer

Herceptin
    Indication: Breast Cancer

Xeloda
    Indication: Breast Cancer



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from United States on 2012-07-11

Patient:

Reactions: Weight Decreased, Thrombosis, Pruritus, Hypokalaemia, Fatigue, Depression, Thrombocytopenia, Alanine Aminotransferase Abnormal, Blood Antidiuretic Hormone Abnormal, Dyspnoea, Nausea, Lymphopenia, Haemoglobin Abnormal, Hyponatraemia, Febrile Neutropenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Diarrhoea, Embolism, Blood Alkaline Phosphatase Abnormal, Dehydration, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: on days 1-14
    Administration route: Oral
    Indication: Breast Cancer Metastatic

Xeloda
    Dosage: beginning on day 8 and continuing to day 21 (total of 14 days)
    Administration route: Oral
    Indication: Breast Cancer Metastatic



Possible Xeloda side effects in female

Reported by a individual with unspecified qualification from United Kingdom on 2012-07-11

Patient: female, weighing 75.0 kg (165.0 pounds)

Reactions: Dehydration, Neutropenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Avastin
    Dosage: date of last dose prior to sae: 21/jun/2012
    Indication: Gastric Cancer
    Start date: 2012-05-10

Cisplatin
    Dosage: date of last dose prior to sae: 21/jun/2012
    Indication: Gastric Cancer
    Start date: 2012-05-10

Epirubicin Hydrochloride
    Dosage: date of last dose prior to sae: 21/jun/2012
    Indication: Gastric Cancer
    Start date: 2012-05-10

Xeloda
    Dosage: date of last dose prior to sae: 28/jun/2012
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-05-10

Other drugs received by patient: Ranitidine; Milk Thistle; COD Liver OIL; Chondroitin + Glucosamine



Possible Xeloda side effects in 67 year old female

Reported by a physician from France on 2012-07-05

Patient: 67 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Neutropenia, Purpura, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Temodal
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-30
    End date: 2012-05-03

Xeloda
    Start date: 2012-05-20

Xeloda
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-20
    End date: 2012-05-03



Possible Xeloda side effects in 67 year old female

Reported by a physician from France on 2012-06-29

Patient: 67 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Haemoglobin Decreased, Condition Aggravated, Neutropenia, Purpura, Thrombocytopenia, Oral Mucosa Erosion, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Temodal
    Dosage: 250 mg, qd, po
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-30
    End date: 2012-05-03

Xeloda
    Dosage: 800 mg, bid, po
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-05-20

Xeloda
    Dosage: 800 mg, bid, po
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-20
    End date: 2012-05-03



Possible Xeloda side effects in 67 year old female

Reported by a physician from France on 2012-06-27

Patient: 67 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Mouth Haemorrhage, Purpura, Neutropenia, Thrombocytopenia, Oral Mucosa Erosion, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Temodal
    Dosage: 200 mg;qd;po
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-30
    End date: 2012-05-03

Xeloda
    Dosage: 800 mg;bid;po
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-20
    End date: 2012-05-21



Possible Xeloda side effects in 67 year old female

Reported by a physician from France on 2012-06-26

Patient: 67 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Purpura, Neutropenia, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Temodal
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-30
    End date: 2012-05-03

Xeloda
    Administration route: Oral
    Indication: Pancreatic Neoplasm
    Start date: 2012-04-20
    End date: 2012-05-21



Possible Xeloda side effects in 77 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-22

Patient: 77 year old female

Reactions: Neutropenic Colitis, Diarrhoea, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cisplatin
    Indication: Breast Cancer
    Start date: 2012-02-08

Cisplatin
    Indication: Gastric Cancer
    Start date: 2012-02-08

Cisplatin
    Start date: 2012-02-29

Cisplatin
    Start date: 2012-02-29

Emend
    Administration route: Oral
    Start date: 2012-02-08
    End date: 2012-03-02

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-02-08
    End date: 2012-03-02

Herceptin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Herceptin
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Other drugs received by patient: Iperten; Allopurinol; Xenetix; Lovenox; Magnesium Sulfate; Cordarone; Bisoprolol Fumarate and Hydrochlorothiazide; Lorazepam; Potassium Chloride; Nexium; Acetaminophen; Tramadol HCL; Zofran



Possible Xeloda side effects in female

Reported by a physician from Poland on 2012-06-22

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Weight Decreased, Metastases To Liver, Tumour Marker Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, General Physical Health Deterioration, Oedema Peripheral, Nail Disorder, Neutropenia, Thrombocytopenia, Asthenia, Leukopenia

Drug(s) suspected as cause:
Docetaxel
    Indication: Breast Cancer
    Start date: 2010-06-25
    End date: 2010-10-24

Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-06-25
    End date: 2011-01-04

Other drugs received by patient: Tamoxifen Citrate; Anastrozole; Vinorelbine; Exemestane; Zoladex



Possible Xeloda side effects in female

Reported by a physician from Germany on 2012-06-20

Patient: female, weighing 58.0 kg (127.6 pounds)

Reactions: Sepsis, Neutropenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Avastin
    Dosage: last dose prior to sae: 21/may/2012
    Indication: Breast Cancer Metastatic
    Start date: 2011-11-07

Vinorelbine Tartrate
    Dosage: last dose prior to sae: 29/may/2012
    Indication: Breast Cancer Metastatic
    Start date: 2011-11-07

Xeloda
    Dosage: last dose prior to sae: 29/may/2012
    Administration route: Oral
    Indication: Breast Cancer Metastatic
    Start date: 2011-11-07

Other drugs received by patient: Insulin



Possible Xeloda side effects in 54 year old female

Reported by a physician from Poland on 2012-06-19

Patient: 54 year old female, weighing 56.0 kg (123.2 pounds)

Reactions: Weight Decreased, Tumour Marker Increased, Metastases To Liver, General Physical Health Deterioration, Palmar-Plantar Erythrodysaesthesia Syndrome, Oedema Peripheral, Nail Disorder, Neutropenia, Thrombocytopenia, Asthenia, Leukopenia

Drug(s) suspected as cause:
Docetaxel
    Indication: Breast Cancer
    Start date: 2010-06-25
    End date: 2010-10-24

Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-06-25

Other drugs received by patient: Exemestane; Anastrozole; Vinorelbine; Tamoxifen; Zoladex



Possible Xeloda side effects in 77 year old female

Reported by a physician from France on 2012-06-15

Patient: 77 year old female

Reactions: Neutropenic Colitis, Diarrhoea, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cisplatin
    Start date: 2012-02-29

Cisplatin
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-02-08
    End date: 2012-02-29

Emend
    Dosage: on day 1, 2 and 3 of 14 day cycle
    Indication: Vomiting
    Start date: 2012-02-08
    End date: 2012-03-02

Herceptin
    Start date: 2012-02-29

Herceptin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Other drugs received by patient: Iperten; Nexium; Allopurinol; Xenetix; Bisoprolol Fumarate and Hydrochlorothiazide; Lovenox; Kaleorid LP; Zofran; Lorazepam; Acetaminophen; Tramadol HCL; Cordarone



Possible Xeloda side effects in male

Reported by a physician from Sweden on 2012-06-12

Patient: male

Reactions: Gastrointestinal Disorder, Metabolic Disorder, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Epirubicin Hydrochloride
    Dosage: last dose prior to sae 23/may/2012
    Indication: Gastric Cancer
    Start date: 2012-05-02

Oxaliplatin
    Dosage: last dose prior to sae 23/may/2012
    Indication: Gastric Cancer
    Start date: 2012-05-02

Xeloda
    Dosage: last dose prior to sae 3/jun/2012
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-05-02

Other drugs received by patient: Clindamycin



Possible Xeloda side effects in female

Reported by a individual with unspecified qualification from Greece on 2012-06-04

Patient: female

Reactions: Vomiting, Hypersensitivity, Anaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Neurotoxicity, Fatigue, Diarrhoea, Neutropenia

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from China on 2012-05-29

Patient:

Reactions: Neurotoxicity, Vomiting, Nausea, Diarrhoea, Neutropenia, Thrombocytopenia, Leukopenia

Drug(s) suspected as cause:
Oxaliplatin
    Indication: Gastric Cancer

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from Spain on 2012-05-28

Patient:

Reactions: Paronychia, Dermatitis Acneiform, Conjunctivitis, Pulmonary Embolism, Palmar-Plantar Erythrodysaesthesia Syndrome, Blepharitis, Mucosal Inflammation, Diarrhoea, Neutropenia, Myocardial Infarction, Eye Disorder, Deep Vein Thrombosis, Keratitis

Drug(s) suspected as cause:
Cetuximab
    Dosage: 2-hr infusion followed by 250 mg/m2.
    Indication: Colorectal Cancer

Cetuximab
    Dosage: weekly dose.

Xeloda
    Administration route: Oral
    Indication: Colorectal Cancer



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from United States on 2012-05-28

Patient:

Reactions: Pain, Mental Status Changes, Pulmonary Embolism, Constipation, Neuropathy Peripheral, Fatigue, Dyspepsia, Oral Candidiasis, Oedema, Decreased Appetite, Hypovolaemia, Blood Alkaline Phosphatase Increased, Vomiting, Dysphagia, Nausea, Febrile Neutropenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Brachial Plexopathy, Anxiety, Mucosal Inflammation, Insomnia, Aspartate Aminotransferase Increased, Dehydration, Neutropenia

Drug(s) suspected as cause:
Paclitaxel
    Dosage: on days 1-8
    Indication: Breast Cancer Metastatic

Xeloda
    Dosage: on days 1-15
    Administration route: Oral
    Indication: Breast Cancer Metastatic



Possible Xeloda side effects in

Reported by a physician from Greece on 2012-05-24

Patient:

Reactions: Large Intestine Perforation, Nausea, Anaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Febrile Neutropenia, Mucosal Inflammation, Fatigue, Diarrhoea, Alopecia, Neutropenia, Thrombocytopenia, Hypertension

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Dosage: on day 1 and every 2 wks

Avastin
    Dosage: on day 1 and every 3 wks
    Indication: Colorectal Cancer Metastatic

Fluorouracil
    Dosage: given per day

Fluorouracil
    Dosage: 22hrs continous infusion day 1 and 2 per day
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride
    Dosage: on day 1

Irinotecan Hydrochloride
    Dosage: on day 1
    Indication: Colorectal Cancer Metastatic

Leucovorin Calcium
    Dosage: on day 1 and 2
    Indication: Colorectal Cancer Metastatic

Xeloda
    Dosage: 1-14 days
    Administration route: Oral
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in female

Reported by a physician from Slovenia on 2012-05-23

Patient: female, weighing 64.0 kg (140.8 pounds)

Reactions: Vomiting, Sepsis, Neutropenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Euthyrox; Naklofen DUO; Haldol; Nexium; Reglan



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