This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Xylocaine (Lidocaine) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (114)
Death (6)
Life Threatening Events (32)
Disability (6)
Reports by Reaction Type
Anaphylactic Shock (18),
Convulsion (13),
Angioedema (9),
Toxicity To Various Agents (9),
Drug Rash With Eosinophilia and Systemic Symptoms (9),
Tachycardia (8),
Eosinophil Count Increased (8),
Toxic Skin Eruption (8),
Loss of Consciousness (7),
Malaise (6),
Shock (6),
Incorrect Route of Drug Administration (5)
Below are a few examples of reports where side effects / adverse reactions may be related to Xylocaine (Lidocaine). For a complete list or a specific selection of reports, please use the links above.
Possible Xylocaine side effects in 57 year old female
Reported by a physician from Japan on 2012-08-24
Patient: 57 year old female
Reactions: Nasal Obstruction, Cyanosis, Laryngeal Obstruction
Drug(s) suspected as cause:
Xylocaine
Dosage: dose unknown
Indication: Local Anaesthesia
Xylocaine Viscous
Dosage: dose unknown
Indication: Local Anaesthesia
Other drugs received by patient: Scopolamine; Gascon
Possible Xylocaine side effects in 70 year old female
Reported by a physician from Japan on 2012-08-21
Patient: 70 year old female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Trimethoprim
Start date: 2012-06-15
End date: 2012-06-15
Xylocaine
Indication: Osteoarthritis
Start date: 2012-06-15
End date: 2012-06-15
Possible Xylocaine side effects in 44 year old male
Reported by a physician from France on 2012-08-16
Patient: 44 year old male
Reactions: Ischaemic Stroke
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xylocaine
Other drugs received by patient: Flecainide Acetate; Bisoprolol Fumarate
Possible Xylocaine side effects in 66 year old female
Reported by a physician from France on 2012-08-13
Patient: 66 year old female
Reactions: Nervous System Disorder, Hyperhidrosis, Hypertensive Crisis, Loss of Consciousness, Clonic Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xylocaine
Administration route: Oral
Indication: Local Anaesthesia
Start date: 2011-11-07
End date: 2011-11-07
Xylocaine
Indication: Local Anaesthesia
Start date: 2011-11-07
End date: 2011-11-07
Xylocaine
Dosage: xilocaine nebulizer, 1 dosage form once/single administration
Administration route: Oral
Start date: 2011-11-07
End date: 2011-11-07
Other drugs received by patient: Keppra; Keppra; Micardis HCT; Glucophage; Amaryl
Possible Xylocaine side effects in 30 year old female
Reported by a consumer/non-health professional from Japan on 2012-08-13
Patient: 30 year old female, weighing 47.0 kg (103.4 pounds)
Reactions: Multi-Organ Failure, Hypoxic-Ischaemic Encephalopathy, Overdose, Toxicity To Various Agents, Convulsion, Loss of Consciousness
Adverse event resulted in: death
Drug(s) suspected as cause:
Xylocaine
Indication: Breast Prosthesis Implantation
Start date: 2010-01-07
End date: 2010-01-07
Xylocaine
Indication: Local Anaesthesia
Start date: 2010-01-07
End date: 2010-01-07
Possible Xylocaine side effects in male
Reported by a physician from France on 2012-08-09
Patient: male
Reactions: Anaphylactic Shock
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Betadine
Dosage: once/sngle administration
Start date: 2011-11-28
End date: 2011-11-28
Cefazolin
Dosage: once/sngle administration
Indication: Antibiotic Prophylaxis
Start date: 2011-11-28
End date: 2011-11-28
Chirocaine
Dosage: once/sngle administration
Indication: Local Anaesthesia
Start date: 2011-11-28
End date: 2011-11-28
Midazolam HCL
Dosage: once/sngle administration
Indication: Anaesthesia
Start date: 2011-11-28
End date: 2011-11-28
Xylocaine
Dosage: once/sngle administration
Indication: Local Anaesthesia
Start date: 2011-11-28
End date: 2011-11-28
Other drugs received by patient: Xanax
Possible Xylocaine side effects in 57 year old male
Reported by a physician from United States on 2012-08-08
Patient: 57 year old male, weighing 54.0 kg (118.8 pounds)
Reactions: Pain in Extremity
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xiapex
Indication: Dupuytren's Contracture
Start date: 2011-11-14
End date: 2011-11-14
Xylocaine
Indication: Local Anaesthesia
Start date: 2011-11-15
End date: 2011-11-15
Other drugs received by patient: Videx; Prevista; Norvir; Ziagen; Acetaminophen
Possible Xylocaine side effects in 30 year old female
Reported by a physician from Japan on 2012-08-06
Patient: 30 year old female, weighing 47.0 kg (103.4 pounds)
Reactions: Multi-Organ Failure, Hypoxic-Ischaemic Encephalopathy, Overdose, Toxicity To Various Agents, Convulsion, Loss of Consciousness
Adverse event resulted in: death
Drug(s) suspected as cause:
Xylocaine
Indication: Breast Prosthesis Implantation
Start date: 2010-01-07
End date: 2010-01-07
Xylocaine
Indication: Local Anaesthesia
Start date: 2010-01-07
End date: 2010-01-07
Possible Xylocaine side effects in 767 month old male
Reported by a physician from France on 2012-08-02
Patient: 767 month old male
Reactions: Angioedema
Drug(s) suspected as cause:
Perindopril Erbumine
Administration route: Oral
Start date: 2011-04-01
End date: 2012-06-01
Xylocaine
Start date: 2012-02-01
Other drugs received by patient: Previscan; Bisoprolol Fumarate; Cordarone; Crestor; Nexium; Aspirin; Lasix
Possible Xylocaine side effects in 75 year old male
Reported by a physician from France on 2012-07-27
Patient: 75 year old male
Reactions: Angioedema
Drug(s) suspected as cause:
Ramipril
Administration route: Oral
Indication: Proteinuria
Start date: 2012-06-01
End date: 2012-06-04
Xylocaine
Start date: 2012-06-04
End date: 2012-06-04
Other drugs received by patient: Plavix; Unspecified Anti Hypertensive Drug; Cymbalta; Irbesartan; Lercanidipine; Crestor; Repaglinide
Possible Xylocaine side effects in 75 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27
Patient: 75 year old male
Reactions: Angioedema, Fall, Face Injury
Drug(s) suspected as cause:
Ramipril
Dosage: 1.25 mg, daily
Administration route: Oral
Indication: Proteinuria
Start date: 2012-06-01
End date: 2012-06-04
Xylocaine
Dosage: unk
Start date: 2012-06-04
End date: 2012-06-04
Other drugs received by patient: Cymbalta; Repaglinide; Plavix; Irbesartan; Crestor; Lercanidipine
Possible Xylocaine side effects in 70 year old female
Reported by a physician from Japan on 2012-07-19
Patient: 70 year old female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Trimethoprim
Start date: 2012-06-15
End date: 2012-06-15
Xylocaine
Indication: Osteoarthritis
Start date: 2012-06-15
End date: 2012-06-15
Possible Xylocaine side effects in female
Reported by a physician from United States on 2012-07-18
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Acetylsalicylic Acid SRT
Dosage: unk
Codeine Sulfate
Dosage: unk
Morphine Sulfate
Dosage: unk
Potassium Penicillin G
Dosage: unk
Xylocaine
Dosage: unk
Possible Xylocaine side effects in 81 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-17
Patient: 81 year old male, weighing 64.0 kg (140.8 pounds)
Reactions: Bundle Branch Block Left
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: Induction and Maintenance of Anaesthesia
Diprivan
Ropivacaine Hydrochloride
Dosage: 100 ml of anapeine (ropivacaine hydrochloride hydrate) was administered by 4ml/hr
Indication: Analgesic Therapy
Xylocaine
Dosage: 2 x105 folding diluted adrenaline: 4 ml
Indication: Epidural Anaesthesia
Other drugs received by patient: Fentanyl; Droperidol; Rocuronium Bromide
Possible Xylocaine side effects in female
Reported by a physician from France on 2012-07-10
Patient: female
Reactions: Tachycardia, Hypotension, Bronchospasm
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Celocurine
Dosage: once/single administration
Indication: Anaesthesia
Start date: 2011-12-01
End date: 2011-12-01
Diprivan
Start date: 2011-12-01
End date: 2011-12-01
Ketamine HCL
Start date: 2011-12-01
End date: 2011-12-01
Sufentanil Citrate
Indication: Anaesthesia
Start date: 2011-12-01
End date: 2011-12-01
Xylocaine
Start date: 2011-12-01
End date: 2011-12-01
Possible Xylocaine side effects in 47 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-06
Patient: 47 year old female
Reactions: Paraplegia
Drug(s) suspected as cause:
Xylocaine
Other drugs received by patient: Papaveretum; Oxygen; Hyoscine HBR HYT; Nitrous Oxygen; Thiopental Sodium
Possible Xylocaine side effects in 8 month old female
Reported by a physician from Japan on 2012-07-06
Patient: 8 month old female, weighing 9.0 kg (19.8 pounds)
Reactions: Overdose, Encephalopathy, Toxicity To Various Agents, Convulsion
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in male
Reported by a physician from France on 2012-07-02
Patient: male
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Tracrium
Indication: Anaesthesia
Start date: 2012-04-02
End date: 2012-04-02
Xylocaine
Indication: Anaesthesia
Start date: 2012-04-02
End date: 2012-04-02
Other drugs received by patient: Potassium Chloride; Diamox; Sufentanil Citrate; Propofol; Athymil; Lasix
Possible Xylocaine side effects in 17 year old male
Reported by a physician from Japan on 2012-07-02
Patient: 17 year old male, weighing 70.0 kg (154.0 pounds)
Reactions: Airway Peak Pressure Increased, Generalised Erythema, Mechanical Ventilation Complication, Rash
Drug(s) suspected as cause:
Atropine
Start date: 2011-06-20
End date: 2011-06-20
Cefazolin Sodium
Start date: 2011-06-20
End date: 2011-06-20
Diprivan
Dosage: 10mg/ml, 1200mg/hr
Indication: General Anaesthesia
Start date: 2011-06-20
Diprivan
Start date: 2011-06-20
End date: 2011-06-20
Fentanyl
Indication: Anaesthesia Procedure
Start date: 2011-06-20
End date: 2011-06-20
Fentanyl
Start date: 2011-06-20
End date: 2011-06-20
Flurbiprofen
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Isotonic Sodium Chloride Solution
Start date: 2011-06-20
End date: 2011-06-20
Mepivacaine HCL
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Mepivacaine HCL
Dosage: 20mg/ml
Physio 140
Start date: 2011-06-20
End date: 2011-06-20
Ropivacaine Hydrochloride
Dosage: 0.375%, 4 ml/hr continuously
Start date: 2011-06-20
End date: 2011-06-20
Ropivacaine Hydrochloride
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Salinhes
Start date: 2011-06-20
End date: 2011-06-20
Ultiva
Indication: Anaesthesia Procedure
Start date: 2011-06-20
End date: 2011-06-20
Ultiva
Dosage: 0.5mg/hr
Start date: 2011-06-20
End date: 2011-06-20
Xylocaine
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Other drugs received by patient: Relaxin; Polaramine; Neophyllin Injection; Hydrocortisone Sodium Succinate; Rocuronium Bromide
Possible Xylocaine side effects in female
Reported by a physician from France on 2012-06-27
Patient: female
Reactions: Incorrect Route of Drug Administration, Tinnitus, Hallucination, Auditory, Tachycardia, Headache, Optic Neuritis, Accidental Overdose, Pallor, Loss of Consciousness, Malaise, Chest Pain, Leukoencephalopathy, Hallucination, Panic Reaction, Monoplegia, Hyperacusis, Nausea, Clonus, Injection Site Pain, Toxicity To Various Agents, Epilepsy, Eye Pain, Tremor, Convulsion, Smoke Sensitivity, Visual Impairment, DRY Eye, Anaesthesia, Venous Occlusion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ketamine HCL
Indication: Neuralgia
Start date: 2008-05-28
End date: 2008-05-30
Xylocaine
Dosage: 10 mg/ml
Indication: Neuralgia
Start date: 2008-05-28
End date: 2008-05-30
Possible Xylocaine side effects in female
Reported by a physician from United States on 2012-06-25
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Benzylpenicillin Potassium
Dosage: unk
Brevital Sodium
Dosage: unk
Phenergan
Dosage: unk
Sulfanilamide
Dosage: unk
Xylocaine
Dosage: unk
Possible Xylocaine side effects in female
Reported by a physician from Sweden on 2012-06-22
Patient: female
Reactions: Drug Effect Prolonged
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xylocaine
Other drugs received by patient: Sufentanil Citrate; Marcaine; Oxycontin; Catapres; Gabapentin; Amitriptyline HCL
Possible Xylocaine side effects in male
Reported by a physician from France on 2012-06-08
Patient: male, weighing 5.0 kg (11.0 pounds)
Reactions: Cyanosis, Bradycardia, Drug Dispensing Error, Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-08
Patient: female
Reactions: Asthma, Abdominal Pain, Dyspnoea, Hypersensitivity, Vomiting, Hypotension, Mental Status Changes, Somnolence, Malaise, Bronchiectasis, Diarrhoea, Cough
Drug(s) suspected as cause:
Inderal
Morphine
Nexium
Administration route: Oral
Prilosec
Administration route: Oral
Pulmicort
Xylocaine
Possible Xylocaine side effects in 17 year old male
Reported by a physician from Japan on 2012-06-04
Patient: 17 year old male, weighing 70.0 kg (154.0 pounds)
Reactions: Airway Peak Pressure Increased, Generalised Erythema, Mechanical Ventilation Complication, Rash
Drug(s) suspected as cause:
Atropine
Start date: 2011-06-20
End date: 2011-06-20
Cefazolin Sodium
Start date: 2011-06-20
End date: 2011-06-20
Diprivan
Start date: 2011-06-20
End date: 2011-06-20
Diprivan
Dosage: 10mg/ml, 1200mg/hr
Indication: General Anaesthesia
Start date: 2011-06-20
Fentanyl
Indication: Anaesthesia Procedure
Start date: 2011-06-20
End date: 2011-06-20
Fentanyl
Start date: 2011-06-20
End date: 2011-06-20
Flurbiprofen
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Isotonic Sodium Chloride Solution
Start date: 2011-06-20
End date: 2011-06-20
Mepivacaine HCL
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Mepivacaine HCL
Dosage: 20mg/ml
Physio 140
Start date: 2011-06-20
End date: 2011-06-20
Ropivacaine Hydrochloride
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Ropivacaine Hydrochloride
Dosage: 0.375%, 4 ml/hr continuously
Start date: 2011-06-20
End date: 2011-06-20
Salinhes
Start date: 2011-06-20
End date: 2011-06-20
Ultiva
Dosage: 0.5mg/hr
Start date: 2011-06-20
End date: 2011-06-20
Ultiva
Indication: Anaesthesia Procedure
Start date: 2011-06-20
End date: 2011-06-20
Xylocaine
Indication: Analgesic Therapy
Start date: 2011-06-20
End date: 2011-06-20
Other drugs received by patient: Rocuronium Bromide; Hydrocortisone Sodium Succinate; Neophyllin Injection; Relaxin; Polaramine
Possible Xylocaine side effects in female
Reported by a pharmacist from United Kingdom on 2012-05-31
Patient: female
Reactions: Incorrect Route of Drug Administration
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in female
Reported by a pharmacist from United Kingdom on 2012-05-31
Patient: female
Reactions: Incorrect Route of Drug Administration
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in 34 year old male
Reported by a physician from Japan on 2012-05-30
Patient: 34 year old male
Reactions: Anaphylactic Reaction
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in 8 month old female
Reported by a physician from Japan on 2012-05-25
Patient: 8 month old female, weighing 9.0 kg (19.8 pounds)
Reactions: Overdose, Encephalopathy, Toxicity To Various Agents, Convulsion
Drug(s) suspected as cause:
Xylocaine
Possible Xylocaine side effects in 45 year old female
Reported by a physician from Sweden on 2012-05-22
Patient: 45 year old female
Reactions: Drug Effect Prolonged
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Xylocaine
Other drugs received by patient: Sufentanil Citrate; Clonidine
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