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Zolinza (Vorinostat) - Febrile Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Febrile Neutropenia (8)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Zolinza (Vorinostat) where reactions include febrile neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Zolinza side effects in

Reported by a physician from United States on 2012-08-23

Patient:

Reactions: White Blood Cell Count Decreased, Febrile Neutropenia, Platelet Count Decreased, Neutrophil Count Decreased

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Temozolomide
    Dosage: 75 mg/m2, qd
    Administration route: Oral
    Start date: 2012-07-23
    End date: 2012-07-30

Zolinza
    Dosage: 300 mg, on days 1-5, qw
    Administration route: Oral
    Start date: 2012-07-23
    End date: 2012-07-30

Zolinza
    Dosage: 300 mg, on days 1-5, qw
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2012-07-02

Temozolomide
    Dosage: 75 mg/m2, qd
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2012-07-02



Possible Zolinza side effects in female

Reported by a physician from United States on 2012-06-04

Patient: female, weighing 64.9 kg (142.8 pounds)

Reactions: White Blood Cell Count Decreased, Pneumonia, Febrile Neutropenia, Disease Progression, Cardiac Failure, Injection Site Reaction, Sepsis, Pleural Effusion, Neutrophil Count Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-11-04
    End date: 2011-11-12

Vidaza
    Dosage: 125 milligram/sq. meter
    Start date: 2011-11-04
    End date: 2011-11-10

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-10

Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-10-04
    End date: 2011-10-12

Mylotarg
    Dosage: 3 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-11

Mylotarg
    Dosage: 5.1 milligram
    Start date: 2011-11-07
    End date: 2011-11-11

Other drugs received by patient: Levothyroxine Sodium; Diphenhydramine HCL; Lipitor; Hydrocodone



Possible Zolinza side effects in 66 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-16

Patient: 66 year old female, weighing 64.9 kg (142.8 pounds)

Reactions: White Blood Cell Count Decreased, Pneumonia, Cardiac Failure, Injection Site Reaction, Pleural Effusion, Febrile Neutropenia, Neutrophil Count Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mylotarg
    Dosage: 3 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-11

Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-11-04
    End date: 2011-11-12

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-10

Mylotarg
    End date: 2011-11-11

Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-10-04
    End date: 2011-10-12

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-11-04

Other drugs received by patient: Hydrocodone; Lipitor; Diphenhydramine HCL; Levothyroxine Sodium



Possible Zolinza side effects in 66 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-02-28

Patient: 66 year old female, weighing 64.9 kg (142.8 pounds)

Reactions: White Blood Cell Count Decreased, Cardiac Failure, Injection Site Reaction, Febrile Neutropenia, Pleural Effusion, Pneumonitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mylotarg
    Dosage: 3 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-11

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-10-04
    End date: 2011-10-10

Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-10-04
    End date: 2011-10-12

Other drugs received by patient: Levothyroxine Sodium; Lipitor; Diphenhydramine HCL; Hydrocodone



Possible Zolinza side effects in 60 year old female

Reported by a physician from United States on 2012-02-07

Patient: 60 year old female, weighing 75.0 kg (165.0 pounds)

Reactions: Acute Myeloid Leukaemia, Sepsis, Febrile Neutropenia, Pyrexia, Disease Progression

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Vidaza
    Dosage: 75 mg/m2, sc or iv on days 1-7
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-09-03

Mylotarg
    Dosage: 3 mg/m2, on days 4 and 8
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-09-07
    End date: 2011-09-07

Zolinza
    Dosage: 400 mg, on days 1-9
    Administration route: Oral
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-09-03

Other drugs received by patient: Acyclovir; Insulin; Oxycodone; Omeprazole; Meperidine HCL; Allopurinol; Aluminium Hydroxide / Diphenhydramine / Magnesium Hydroxide / Lidocaine; Acetaminophen; Chlorhexidine Gluconate; Albuterol; Loratadine; Ondansetron; Diphenhydramine; Lorazepam; Metoclopramide; Prochlorperazine



Possible Zolinza side effects in 65 year old male

Reported by a physician from United States on 2012-01-26

Patient: 65 year old male, weighing 70.0 kg (153.9 pounds)

Reactions: Respiratory Failure, Sepsis, Febrile Neutropenia, Pneumonitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-08-23

Mylotarg
    Dosage: 3 milligram/sq. meter
    Start date: 2011-10-25
    End date: 2011-10-31

Zolinza
    Dosage: 400 milligram
    Administration route: Oral
    Start date: 2011-10-25
    End date: 2011-11-02

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-08-23

Mylotarg
    Dosage: 3 milligram/sq. meter
    Start date: 2011-08-23

Vidaza
    Dosage: 75 milligram/sq. meter
    Start date: 2011-10-25
    End date: 2011-10-30



Possible Zolinza side effects in 66 year old female

Reported by a physician from United States on 2012-01-26

Patient: 66 year old female, weighing 64.9 kg (142.8 pounds)

Reactions: White Blood Cell Count Decreased, Cardiac Failure, Injection Site Reaction, Febrile Neutropenia, Pleural Effusion, Pneumonitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zolinza
    Dosage: 400 mg, on days 1-9
    Administration route: Oral
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-12

Mylotarg
    Dosage: 3 mg/m2, on days 4 and 8
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-11

Vidaza
    Dosage: 75 mg/m2, on days 1-7
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-10

Other drugs received by patient: Hydrocodone; Lipitor; Benadryl; Levothyroxine Sodium



Possible Zolinza side effects in 66 year old female

Reported by a physician from United States on 2011-11-23

Patient: 66 year old female, weighing 64.9 kg (142.8 pounds)

Reactions: White Blood Cell Count Decreased, Cardiac Failure, Injection Site Reaction, Febrile Neutropenia, Pleural Effusion, Pneumonitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Azacitidine
    Dosage: 75 mg/m2/day, sc or iv on days 1-7 (total dose this course: 896mg)
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-10

Zolinza
    Dosage: 400 mg, 1x/day on days 1-9 (total dose this course: 3600mg)
    Administration route: Oral
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-12

Mylotarg
    Dosage: 3 mg/m2, over 2 hrs on days 4 and 8 (total dose this course: 10.2mg)
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-10-04
    End date: 2011-10-11

Other drugs received by patient: Levothyroxine Sodium; Benadryl; Hydrocodone; Lipitor

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