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Zosyn (Piperacillin / Tazobactam) - Hepatic Function Abnormal - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Hepatic Function Abnormal (16)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Zosyn (Piperacillin / Tazobactam) where reactions include hepatic function abnormal. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Zosyn side effects in 88 year old female

Reported by a physician from Japan on 2012-06-29

Patient: 88 year old female, weighing 46.0 kg (101.2 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zosyn
    Dosage: 9 g, unk
    Indication: Pneumonia
    Start date: 2012-04-03
    End date: 2012-04-04

Zosyn
    Dosage: 13.5 g, unk
    Indication: Urinary Tract Infection
    Start date: 2012-04-05
    End date: 2012-04-17

Other drugs received by patient: Famotidine; Silvinol; Equa; Furosemide; Diart; Nicorandil; Lacb R



Possible Zosyn side effects in 88 year old female

Reported by a physician from Japan on 2012-06-13

Patient: 88 year old female

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zosyn
    Indication: Urinary Tract Infection

Zosyn
    Dosage: 4.5 mg, 2x/day
    Indication: Pneumonia
    Start date: 2012-04-03
    End date: 2012-04-17

Other drugs received by patient: Diart; Lacb R; Famotidine; Nicorandil; Equa



Possible Zosyn side effects in 66 year old male

Reported by a physician from Japan on 2012-04-25

Patient: 66 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Hepatic Function Abnormal, Renal Impairment, Diarrhoea, Pancytopenia, Rash, Pyrexia

Drug(s) suspected as cause:
Pepcid
    Administration route: Oral
    Indication: Gastrooesophageal Reflux Disease
    Start date: 2012-02-13
    End date: 2012-02-14

Pepcid RPD
    Administration route: Oral
    Indication: Gastrooesophageal Reflux Disease
    Start date: 2012-02-12
    End date: 2012-02-12

Zolpidem
    Administration route: Oral
    Indication: Insomnia
    Start date: 2012-01-28
    End date: 2012-02-12

Acetaminophen
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-06
    End date: 2012-01-25

Acetaminophen
    Administration route: Oral
    Start date: 2012-01-26
    End date: 2012-02-12

Loxonin
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-31
    End date: 2012-02-12

Solantal
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-28
    End date: 2012-02-12

Zosyn
    Start date: 2012-03-03
    End date: 2012-03-04

UFT
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-20
    End date: 2012-02-12

Zosyn
    Start date: 2012-02-12
    End date: 2012-02-18

Other drugs received by patient: Acetylcysteine; Cefazolin Sodium; Urso 250; Maglax (Magnesium Oxide)



Possible Zosyn side effects in 66 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-24

Patient: 66 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Hepatic Function Abnormal, Renal Impairment, Diarrhoea, Pancytopenia, Pyrexia, Rash

Drug(s) suspected as cause:
Acetaminophen
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-06
    End date: 2012-01-25

Loxonin
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-31
    End date: 2012-02-12

Zolpidem
    Administration route: Oral
    Indication: Insomnia
    Start date: 2012-01-28
    End date: 2012-02-12

Famotidine
    Administration route: Oral
    Start date: 2012-02-13
    End date: 2012-02-14

Zosyn
    Start date: 2012-03-03
    End date: 2012-03-04

Zosyn
    Start date: 2012-02-12
    End date: 2012-02-18

Famotidine
    Administration route: Oral
    Start date: 2012-02-12
    End date: 2012-02-12

Acetaminophen
    Administration route: Oral
    Start date: 2012-01-26
    End date: 2012-02-12

UFT
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-20
    End date: 2012-02-12

Solantal
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-28
    End date: 2012-02-12

Other drugs received by patient: Magnesium Sulfate; Urso 250; Cefazolin Sodium; Acetylcysteine



Possible Zosyn side effects in 77 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-12

Patient: 77 year old female, weighing 43.0 kg (94.6 pounds)

Reactions: Hepatic Function Abnormal, Renal Impairment, Platelet Count Decreased, Condition Aggravated

Adverse event resulted in: death

Drug(s) suspected as cause:
Vancomycin
    Indication: Sepsis
    Start date: 2012-01-20
    End date: 2012-01-20

Unasyn
    Indication: Sepsis
    Start date: 2012-01-19
    End date: 2012-02-19

Vancomycin
    Start date: 2012-01-21
    End date: 2012-01-25

Zosyn
    Indication: Sepsis
    Start date: 2012-01-20



Possible Zosyn side effects in 59 year old male

Reported by a physician from Japan on 2012-04-12

Patient: 59 year old male, weighing 72.0 kg (158.4 pounds)

Reactions: Hepatic Function Abnormal

Drug(s) suspected as cause:
Heparin Sodium
    Indication: Pneumonia
    Start date: 2012-01-23
    End date: 2012-01-27

Vancomycin
    Indication: Pneumonia
    Start date: 2012-01-25
    End date: 2012-02-16

Zosyn
    Indication: Pneumonia
    Start date: 2012-01-23
    End date: 2012-01-27

Zosyn
    Start date: 2012-02-08
    End date: 2012-02-20

Other drugs received by patient: Meropenem



Possible Zosyn side effects in female

Reported by a pharmacist from Japan on 2012-04-10

Patient: female, weighing 57.0 kg (125.4 pounds)

Reactions: Hepatic Function Abnormal, Restlessness, Disseminated Intravascular Coagulation, Pancytopenia, Pyrexia, Fatigue, Malaise, Cardiac Failure, Interstitial Lung Disease, Dehydration, Bone Marrow Failure, Blood Pressure Decreased, Decreased Appetite, Anuria, Deep Vein Thrombosis

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Doxil
    Start date: 2010-11-24
    End date: 2010-11-24

Doxil
    Start date: 2010-11-24
    End date: 2010-11-24

Doxil
    Indication: Malignant Peritoneal Neoplasm
    Start date: 2010-12-22
    End date: 2010-12-22

Doxil
    Indication: Ovarian Cancer Recurrent
    Start date: 2010-12-22
    End date: 2010-12-22

Cisplatin W / Docetaxel
    Indication: Malignant Peritoneal Neoplasm

Cyclophosphamide
    Indication: Malignant Peritoneal Neoplasm

Zosyn
    Indication: Interstitial Lung Disease
    Start date: 2011-01-14
    End date: 2011-02-06

Minocycline Hydrochloride
    Indication: Infection
    Start date: 2011-01-29
    End date: 2011-01-31

Minocycline Hydrochloride
    Indication: Pyrexia
    Start date: 2011-01-29
    End date: 2011-01-31

Taxotere
    Indication: Malignant Peritoneal Neoplasm

Other drugs received by patient: Methycobal; Futhan; Recomodulin; Norvasc; Elaspol; Pentamidine Isethionate; Gosha-Jinki-GAN; Bactrim; Solu-Medrol; Zithromax; Predopa; Dalteparin Sodium; Reminaron; Bactrim; Solu-Medrol; Solu-Medrol; Mucosta; DAI-Kenchu-TO; Futhan; Dalteparin Sodium; Prodif; Humulin R; Magnesium Oxide; Midazolam HCL; Midazolam HCL; Vancomycin Hydrochloride; Pentamidine Isethionate; Predopa; Vancomycin Hydrochloride; Dalteparin Sodium; Prednisolone; Concentrated Human Blood Platelets



Possible Zosyn side effects in 66 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-05

Patient: 66 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Renal Impairment, Hepatic Function Abnormal, Diarrhoea, Pancytopenia, Rash, Pyrexia

Drug(s) suspected as cause:
Acetaminophen
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-06
    End date: 2012-01-25

Loxonin
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-31
    End date: 2012-02-12

Zosyn
    Start date: 2012-03-03
    End date: 2012-03-04

Zosyn
    Start date: 2012-02-12
    End date: 2012-02-18

Zolpidem
    Administration route: Oral
    Indication: Insomnia
    Start date: 2012-01-28
    End date: 2012-02-12

Famotidine
    Administration route: Oral
    Start date: 2012-02-13
    End date: 2012-02-14

UFT
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-20
    End date: 2012-02-12

Famotidine
    Administration route: Oral
    Start date: 2012-02-12
    End date: 2012-02-12

Solantal
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-28
    End date: 2012-02-12

Acetaminophen
    Administration route: Oral
    Start date: 2012-01-26
    End date: 2012-02-12

Other drugs received by patient: Urso 250; Cefazolin Sodium; Magnesium Sulfate; Acetylcysteine



Possible Zosyn side effects in 66 year old male

Reported by a physician from Japan on 2012-04-04

Patient: 66 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Hepatic Function Abnormal, Renal Impairment, Diarrhoea, Pancytopenia, Rash, Pyrexia

Drug(s) suspected as cause:
Pepcid
    Administration route: Oral
    Indication: Gastrooesophageal Reflux Disease
    Start date: 2012-02-13
    End date: 2012-02-14

Zolpidem
    Administration route: Oral
    Indication: Insomnia
    Start date: 2012-01-28
    End date: 2012-02-12

UFT
    Indication: Nasopharyngeal Cancer

Acetaminophen
    Administration route: Oral
    Start date: 2012-01-26
    End date: 2012-02-12

UFT
    Administration route: Oral
    Start date: 2012-01-20
    End date: 2012-02-12

Solantal
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-28
    End date: 2012-02-12

Zosyn
    Start date: 2012-02-12
    End date: 2012-02-18

Loxonin
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-31
    End date: 2012-02-12

Pepcid RPD
    Administration route: Oral
    Indication: Gastrooesophageal Reflux Disease
    Start date: 2012-02-12
    End date: 2012-02-12

Acetaminophen
    Administration route: Oral
    Indication: Nasopharyngeal Cancer
    Start date: 2012-01-06
    End date: 2012-01-25

Zosyn
    Start date: 2012-03-03
    End date: 2012-03-04

Other drugs received by patient: Acetylcysteine; Maglax (Magnesium Oxide); Cefazolin Sodium; Urso 250



Possible Zosyn side effects in 59 year old male

Reported by a physician from Japan on 2012-03-13

Patient: 59 year old male, weighing 72.0 kg (158.4 pounds)

Reactions: Hepatic Function Abnormal

Drug(s) suspected as cause:
Vancomycin
    Indication: Pneumonia
    Start date: 2012-01-25
    End date: 2012-02-16

Zosyn
    Start date: 2012-02-08
    End date: 2012-02-20

Heparin Sodium
    Indication: Pneumonia
    Start date: 2012-01-23
    End date: 2012-01-27

Zosyn
    Indication: Pneumonia
    Start date: 2012-01-23
    End date: 2012-01-27

Other drugs received by patient: Meropenem



Possible Zosyn side effects in

Reported by a physician from Japan on 2012-03-05

Patient:

Reactions: Hepatic Function Abnormal, Interstitial Lung Disease, Drug Interaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clindamycin HCL

Zosyn

Ceftazidime Sodium



Possible Zosyn side effects in 95 year old female

Reported by a physician from Japan on 2012-02-03

Patient: 95 year old female

Reactions: Hepatic Function Abnormal

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Zosyn
    Dosage: 4.5 g, 3x/day
    Indication: Pneumonia
    Start date: 2011-06-04
    End date: 2011-06-06

Cefoperazone Sodium
    Dosage: 2 g/day
    Indication: Pneumonia
    Start date: 2011-06-03
    End date: 2011-06-04

Other drugs received by patient: Lasix; Depakene; Omeprazole; Magnesium Hydroxide TAB; Soldactone; Decadron; Adona



Possible Zosyn side effects in male

Reported by a physician from Japan on 2011-12-20

Patient: male, weighing 64.0 kg (140.8 pounds)

Reactions: Hepatic Function Abnormal, Pyrexia

Drug(s) suspected as cause:
Lamisil
    Dosage: 125 mg
    Administration route: Oral
    Indication: Tinea Pedis
    Start date: 2011-10-01
    End date: 2011-11-17

Zosyn
    Start date: 2011-11-14
    End date: 2011-11-16

Other drugs received by patient: Famotidine; Diovan; Sword; Prednisolone; Allopurinol; Tamsulosin HCL; Mestinon



Possible Zosyn side effects in 82 year old male

Reported by a physician from Japan on 2011-12-06

Patient: 82 year old male

Reactions: Death, Hepatic Function Abnormal, Bone Marrow Failure

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Zosyn



Possible Zosyn side effects in 82 year old male

Reported by a physician from Japan on 2011-11-30

Patient: 82 year old male

Reactions: Death, Hepatic Function Abnormal, Bone Marrow Failure

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Zosyn



Possible Zosyn side effects in 85 year old male

Reported by a pharmacist from Japan on 2011-11-28

Patient: 85 year old male

Reactions: Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased, Hepatic Function Abnormal, Gamma-Glutamyltransferase Increased, Liver Function Test Abnormal, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Zosyn
    Dosage: 6.75g per day
    Indication: Product Used FOR Unknown Indication

Intralipid 10%
    Indication: Product Used FOR Unknown Indication

Arixtra
    Dosage: 2.5mg per day
    Indication: Thrombosis Prophylaxis
    Start date: 2011-11-16
    End date: 2011-11-17

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