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Zyvox (Linezolid) - Serotonin Syndrome - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Serotonin Syndrome (23)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Zyvox (Linezolid) where reactions include serotonin syndrome. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Zyvox side effects in

Reported by a physician from United States on 2012-07-30

Patient:

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Seroquel
    Administration route: Oral

Celexa

Zyvox



Possible Zyvox side effects in

Reported by a physician from United States on 2012-07-19

Patient:

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Celexa
    Dosage: unk

Zyvox
    Dosage: unk

Seroquel
    Dosage: unk



Possible Zyvox side effects in 51 year old male

Reported by a pharmacist from Spain on 2012-06-28

Patient: 51 year old male

Reactions: Mania, Drug Interaction, Serotonin Syndrome

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Fluvoxamine Maleate
    Dosage: 100 mg, 3x/day
    Administration route: Oral
    Indication: Depression
    Start date: 2010-11-26
    End date: 2012-05-12

Other drugs received by patient: Clozapine; Topamax; Tramadol



Possible Zyvox side effects in

Reported by a pharmacist from United States on 2012-05-30

Patient:

Reactions: Death, Serotonin Syndrome, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox



Possible Zyvox side effects in 57 year old male

Reported by a pharmacist from Spain on 2012-05-25

Patient: 57 year old male

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Dolantina
    Indication: Analgesic Therapy

Zyvox
    Indication: Pleural Infection

Dolantina
    Dosage: 15 mg, hour
    Indication: Postoperative Analgesia
    Start date: 2011-08-02
    End date: 2011-08-13

Other drugs received by patient: Anidulafungin; Enoxaparin; Actrapid; Midazolam; Amikacin; Meperidine HCL; Meropenem; Propofol



Possible Zyvox side effects in female

Reported by a pharmacist from United States on 2012-05-10

Patient: female, weighing 102.7 kg (225.9 pounds)

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Cymbalta
    Dosage: 60 mg, daily
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-20

Bupropion HCL
    Dosage: 150 mg, 3x/day
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-21

Other drugs received by patient: Midazolam; Metoprolol; Metoprolol; Hydrocortisone; Fentanyl; Zolpidem; Diazepam; Amiodarone; Morphine; Simvastatin; Fluoxetine; Diphenhydramine; Venlafaxine



Possible Zyvox side effects in female

Reported by a consumer/non-health professional from United States on 2012-05-03

Patient: female, weighing 106.6 kg (234.5 pounds)

Reactions: Hyperthermia Malignant, Drug Interaction, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Zyvox
    Indication: Pyrexia

Zyvox

Wellbutrin
    Dosage: 75 mg, 2x/day
    Administration route: Oral
    Indication: Serotonin Syndrome

Bupropion HCL
    Dosage: 150 mg, 3x/day
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-21

Cymbalta
    Dosage: 60 mg, daily
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-20

Zyvox
    Indication: Staphylococcal Infection

Zyvox
    Indication: Infection

Wellbutrin
    Dosage: unk
    Administration route: Oral

Other drugs received by patient: Acetylsalicylic Acid; Versed; Morphine; Diphenhydramine; Senokot; Mucomyst; Zolpidem; Melatonin; Hydrocortisone; Diazepam; Venlafaxine; Fluoxetine; Amiodarone; Nexium; Atrovent; Simvastatin; Doripenem; Lisinopril; Metoprolol; Coreg; Midazolam; Ditropan; Mirapex; Bumex; Fentanyl



Possible Zyvox side effects in female

Reported by a pharmacist from United States on 2012-04-24

Patient: female, weighing 102.7 kg (225.9 pounds)

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Cymbalta
    Dosage: 60 mg, daily
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-20

Bupropion
    Dosage: 150 mg, 3x/day
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-21

Other drugs received by patient: Hydrocortisone; Morphine; Fentanyl; Amiodarone; Metoprolol; Midazolam; Diazepam; Fluoxetine; Zolpidem; Venlafaxine; Diphenhydramine; Metoprolol; Simvastatin



Possible Zyvox side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-04

Patient: female, weighing 66.7 kg (146.7 pounds)

Reactions: Overdose, Bacteraemia, Disorientation, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zyvox
    Start date: 2012-01-18
    End date: 2012-01-19

Lexapro
    Dosage: 40 mg
    Indication: Depression
    End date: 2012-01-19



Possible Zyvox side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-02

Patient:

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Zyvox



Possible Zyvox side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-30

Patient: female, weighing 66.7 kg (146.7 pounds)

Reactions: Bacteraemia, Disorientation, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zyvox
    Start date: 2012-01-18
    End date: 2012-01-19

Lexapro
    Dosage: 40 mg
    Indication: Depression
    End date: 2012-01-19



Possible Zyvox side effects in female

Reported by a pharmacist from United States on 2012-03-27

Patient: female, weighing 102.7 kg (225.9 pounds)

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Cymbalta
    Dosage: 60 mg, daily
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-20

Ibuprofen
    Dosage: 150 mg, 3x/day
    Administration route: Oral
    Indication: Depression
    End date: 2011-07-21

Other drugs received by patient: Morphine; Metoprolol; Midazolam; Metoprolol; Diazepam; Fentanyl; Simvastatin; Zolpidem; Fluoxetine; Amiodarone; Diphenhydramine; Venlafaxine; Hydrocortisone



Possible Zyvox side effects in

Reported by a pharmacist from United States on 2012-02-29

Patient:

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox



Possible Zyvox side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-31

Patient:

Reactions: Serotonin Syndrome, Disorientation

Drug(s) suspected as cause:
Zyvox
    Dosage: unk

Lexapro
    Dosage: unk



Possible Zyvox side effects in 76 year old female

Reported by a consumer/non-health professional from United States on 2012-01-11

Patient: 76 year old female

Reactions: Nervous System Disorder, Pyrexia, Serotonin Syndrome, Pupillary Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Cymbalta

Zyvox
    Dosage: 600mg 2 x day
    Indication: Pneumonia Staphylococcal
    Start date: 2011-07-18

Zyvox
    Dosage: 600mg 2 x day
    Indication: Staphylococcal Infection
    Start date: 2011-07-18

Zyvox
    Dosage: 600mg 2 x day
    Indication: Pneumonia Staphylococcal
    Start date: 2011-07-21

Zyvox
    Dosage: 600mg 2 x day
    Indication: Staphylococcal Infection
    Start date: 2011-07-21

Wellbutrin



Possible Zyvox side effects in 79 year old female

Reported by a physician from France on 2011-12-29

Patient: 79 year old female, weighing 65.0 kg (143.0 pounds)

Reactions: Myoclonus, Encephalopathy, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zyvox
    Dosage: 600 mg, 2x/day
    Indication: Perirectal Abscess
    Start date: 2010-03-24
    End date: 2010-03-30

Metronidazole
    Dosage: 500 mg, 3x/day
    Start date: 2010-03-22
    End date: 2010-04-10

Other drugs received by patient: Ofloxacin; Vancomycin



Possible Zyvox side effects in 57 year old male

Reported by a pharmacist from Spain on 2011-12-06

Patient: 57 year old male

Reactions: Drug Interaction, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient possibly interacting with the suspect drug:
Dolantina
    Dosage: 15 mg, 1x/day
    Indication: Postoperative Analgesia
    Start date: 2011-08-02
    End date: 2011-08-13

Other drugs received by patient: Meropenem; Anidulafungin; Amikacin; Propofol



Possible Zyvox side effects in

Reported by a pharmacist from United States on 2011-12-05

Patient:

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Zyvox
    Dosage: unk

Fentanyl-100



Possible Zyvox side effects in

Reported by a pharmacist from United States on 2011-11-30

Patient:

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Zyvox
    Dosage: unk

Fentanyl



Possible Zyvox side effects in 70 year old female

Reported by a physician from United States on 2011-11-17

Patient: 70 year old female

Reactions: Pyrexia, Serotonin Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Zyvox

Other drugs received by patient: Lexapro



Possible Zyvox side effects in 54 year old male

Reported by a pharmacist from Japan on 2011-10-24

Patient: 54 year old male, weighing 54.0 kg (118.8 pounds)

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Zyvox
    Dosage: 600 mg, 2x/day
    Indication: Post Procedural Infection
    Start date: 2011-07-16
    End date: 2011-07-22

Nortriptyline HCL
    Dosage: 20 mg, 1x/day
    Administration route: Oral
    Indication: Intervertebral Disc Protrusion
    Start date: 2011-06-02
    End date: 2011-07-22

Other drugs received by patient: Pentasa; Codeine Phosphate; Imuran; Lyrica; Codeine Phosphate



Possible Zyvox side effects in female

Reported by a physician from United States on 2011-10-19

Patient: female

Reactions: Serotonin Syndrome

Drug(s) suspected as cause:
Celexa
    Dosage: unk

Zyvox
    Dosage: unk



Possible Zyvox side effects in 79 year old female

Reported by a physician from France on 2011-10-07

Patient: 79 year old female, weighing 65.0 kg (143.0 pounds)

Reactions: Myoclonus, Encephalopathy, Serotonin Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metronidazole
    Dosage: 500 mg, 3x/day
    Start date: 2010-03-22
    End date: 2010-04-10

Zyvox
    Dosage: 600 mg, 2x/day
    Indication: Perirectal Abscess
    Start date: 2010-03-24
    End date: 2010-03-30

Ofloxacin
    Dosage: 200 mg, 2x/day
    Start date: 2010-03-22
    End date: 2010-03-28

Vancomycin
    Dosage: 2400 mg, 1x/day
    Indication: Perirectal Abscess
    Start date: 2010-03-22
    End date: 2010-03-24

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