The main purpose of this study is to determine if oxycodone and naltrexone combination
capsules (ALO-02) have the potential to be abused.
Maximum Observed Plasma Concentration (Cmax) of oxymorphoneMaximum Observed Plasma Concentration (Cmax) of noroxycodone
Bad Drug Effects: Peak Effect (Emax)
Nausea: Peak Effect (Emax)
Feel Sick: Peak Effect (Emax)
Sleepy: Peak Effect (Emax)
Dizzy: Peak Effect (Emax)
Pupillometry: Peak Effect (Emax)
Good Drug Effects: Peak Effect (Emax)
Any Drug Effects: Peak Effect (Emax)
Maximum Observed Plasma Concentration (Cmax) of oxycodone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of oxycodone
Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast) for oxycodone
Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUCinf) for oxycodone
Area under the Concentration-Time Curve (AUC0-1h) for oxycodone
Area under the Concentration-Time Curve (AUC0-2h) for oxycodone
Area under the Concentration-Time Curve (AUC0-8h) for oxycodone
Area under the Concentration-Time Curve (AUC0-12h) for oxycodone
Area under the Concentration-Time Curve (AUC0-24h) for oxycodone
Plasma Decay Half-Life (t1/2) for oxycodone
Drug Liking: Time to Maximum (Peak) Effect (TEmax)
High: Time to Maximum (Peak) Effect (TEmax)
Good Effects: Time to Maximum (Peak) Effect (TEmax)
Any Effects: Time to Maximum (Peak) Effect (TEmax)
Bad Effects: Time to Maximum (Peak) Effect (TEmax)
Nausea: Time to Maximum (Peak) Effect (TEmax)
Feel Sick: Time to Maximum (Peak) Effect (TEmax)
Sleepy: Time to Maximum (Peak) Effect (TEmax)
Dizzy: Time to Maximum (Peak) Effect (TEmax)
Pupillometry: Time to Maximum (Peak) Effect (TEmax)
Take Drug Again: Peak Effect (Emax)
Take Drug Again: Mean Effect (Emean)
Take Drug Again: Minimum Effect (Emin)
Overall Drug Liking: Peak Effect (Emax)
Overall Drug Liking: Minimum Effect (Emin)
Overall Drug Liking: Mean Effect (Emean)
Drug Liking: Area Under Effect Curve (AUE) From 0-1 Hours
High: Area Under Effect Curve (AUE) From 0-1 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-1 Hours
Nausea: Area Under Effect Curve (AUE) From 0-1 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-1 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-1 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-1 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-1 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-1 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-1 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Nausea: Area Under Effect Curve (AUE) From 0-2 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-2 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-2 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-2 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-2 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Drug Liking: Area Under Effect Curve (AUE) From 0-8 Hours
Drug Liking: Area Under Effect Curve (AUE) From 0-12 Hours
Drug Liking: Area Under Effect Curve (AUE) From 0-24 Hours
Drug Liking: Area Under Effect Curve (AUE) From 0-36 Hours
High: Area Under Effect Curve (AUE) From 0-8 Hours
High: Area Under Effect Curve (AUE) From 0-12 Hours
High: Area Under Effect Curve (AUE) From 0-24 Hours
High: Area Under Effect Curve (AUE) From 0-36 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-12 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Any Effects: Area Under Effect Curve (AUE) From 0-36 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-12 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Good Effects: Area Under Effect Curve (AUE) From 0-36 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-12 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Bad Effects: Area Under Effect Curve (AUE) From 0-36 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-8 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-12 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-24 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-36 Hours
Nausea: Area Under Effect Curve (AUE) From 0-8 Hours
Nausea: Area Under Effect Curve (AUE) From 0-12 Hours
Nausea: Area Under Effect Curve (AUE) From 0-24 Hours
Nausea: Area Under Effect Curve (AUE) From 0-36 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-8 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-12 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-24 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-36 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-8 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-12 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-24 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-36 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-8 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-12 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-24 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-36 Hours
Maximum Observed Plasma Concentration (Cmax) of naltrexone
Maximum Observed Plasma Concentration (Cmax) of 6-beta-naltrexol
Time to Reach Maximum Observed Plasma Concentration (Tmax) of oxymorphone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of noroxycodone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of naltrexone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of 6-beta-naltrexol
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.