To compare the efficacy and safety of dapsone versus atovaquone in preventing or delaying
the onset of histologically proven or probable Pneumocystis carinii pneumonia in
HIV-infected patients with CD4 counts <= 200 cells/mm3 or <= 15 percent of the total
lymphocyte count who are intolerant to trimethoprim and/or sulfonamides.
Trimethoprim/sulfamethoxazole (TMP/SMX), which is effective for secondary PCP prophylaxis,
is associated with allergic manifestations and side effects that limit its use. Patients who
are intolerant of TMP/SMX require an effective alternative. Dapsone and atovaquone have both
shown promise as PCP prophylactic agents.
Minimum age: 13 Years.
Maximum age: N/A.
Gender(s): Both.
Mbeya Med. Research Program, Mbeya Referral Hosp. CRS, Mbeya, Tanzania
Alabama Therapeutics CRS, Birmingham, Alabama 35294, United States
USC CRS, Los Angeles, California 900331079, United States
Stanford CRS, Palo Alto, California 943055107, United States
Ucsd, Avrc Crs, San Diego, California 921036325, United States
Ucsf Aids Crs, San Francisco, California 941102859, United States
Santa Clara Valley Med. Ctr., San Jose, California 951282699, United States
San Mateo County AIDS Program, San Mateo, California, United States
Harbor-UCLA Med. Ctr. CRS, Torrance, California 90502, United States
University of Colorado Hospital CRS, Aurora, Colorado 80262, United States
Howard University Hosp., Div. of Infectious Diseases, ACTU, Washington, District of Columbia 20059, United States
Univ. of Miami AIDS CRS, Miami, Florida 331361013, United States
Emory Univ. Hemophilia Program Office, Atlanta, Georgia 303652225, United States
Queens Med. Ctr., Honolulu, Hawaii 96816, United States
Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu, Hawaii 96816, United States
Cook County Hosp. CORE Ctr., Chicago, Illinois 60612, United States
Northwestern University CRS, Chicago, Illinois 60611, United States
Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois 60612, United States
Weiss Memorial Hosp., Chicago, Illinois 60640, United States
Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana 462025250, United States
Univ. of Iowa Healthcare, Div. of Infectious Diseases, Iowa City, Iowa 52242, United States
Johns Hopkins Adult AIDS CRS, Baltimore, Maryland 21287, United States
Beth Israel Deaconess - East Campus A0102 CRS, Boston, Massachusetts 02215, United States
Bmc Actg Crs, Boston, Massachusetts 02118, United States
Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States
Hennepin County Med. Ctr., Div. of Infectious Diseases, Minneapolis, Minnesota 55415, United States
University of Minnesota, ACTU, Minneapolis, Minnesota 55455, United States
St. Louis ConnectCare, Infectious Diseases Clinic, St Louis, Missouri, United States
Washington U CRS, St. Louis, Missouri, United States
Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr., Omaha, Nebraska, United States
SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York 13210, United States
Beth Israel Med. Ctr. (Mt. Sinai), New York, New York, United States
NY Univ. HIV/AIDS CRS, New York, New York, United States
Univ. of Rochester ACTG CRS, Rochester, New York 14642, United States
Unc Aids Crs, Chapel Hill, North Carolina, United States
Carolinas HealthCare System, Carolinas Med. Ctr., Charlotte, North Carolina 28203, United States
Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro, North Carolina 27401, United States
Wake County Health and Human Services CRS, Raleigh, North Carolina 27610, United States
Univ. of Cincinnati CRS, Cincinnati, Ohio, United States
Case CRS, Cleveland, Ohio 44106, United States
MetroHealth CRS, Cleveland, Ohio, United States
The Ohio State Univ. AIDS CRS, Columbus, Ohio 432101228, United States
Hosp. of the Univ. of Pennsylvania CRS, Philadelphia, Pennsylvania 19104, United States
University of Washington AIDS CRS, Seattle, Washington 981224304, United States
El-Sadr WM, Murphy RL, Yurik TM, Luskin-Hawk R, Cheung TW, Balfour HH Jr, Eng R, Hooton TM, Kerkering TM, Schutz M, van der Horst C, Hafner R. Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both. Community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group. N Engl J Med. 1998 Dec 24;339(26):1889-95.
Caldwell P, Murphy R, Chan C, Yurik T, Scott J, el-Sadr W. Atovaquone suspension (ATQ) for prophylaxis of Pneumocystis carinii pneumonia (PCP): effects of baseline prophylaxis on safety and efficacy. Int Conf AIDS. 1998;12:297 (abstract no 22178)
Murphy R, El-Sadr W, Cheung T, Luskin-Hawk R, Yurik T, Neaton J, Hafner R. Impact of protease inhibitor containing regimens on the risk of developing opportunistic infections and mortality in the CPCRA 034/ACTG 277 study. Conf Retroviruses Opportunistic Infect. 1998 Feb 1-5;5th:113 (abstract no 181)